STRINGSTRING
G6PD G6PD SIRT1 SIRT1 SUPT6H SUPT6H DDX39B DDX39B MYOCD MYOCD CTDP1 CTDP1 FRS2 FRS2 ACTN3 ACTN3 EZH2 EZH2 MYLK3 MYLK3 NFATC1 NFATC1 PRDM6 PRDM6 SLC25A4 SLC25A4 PDGFB PDGFB HDAC9 HDAC9 CYP26B1 CYP26B1 SMAD4 SMAD4 BMP4 BMP4 AKAP6 AKAP6 ZEB1 ZEB1 RBPMS2 RBPMS2 MYF5 MYF5 NRG1 NRG1 XBP1 XBP1 NLN NLN CAMK1 CAMK1 SMAD1 SMAD1 H0VDT0_CAVPO H0VDT0_CAVPO NEU2 NEU2 Cdk9 Cdk9 ATP11A ATP11A YBX1 YBX1 TOMM70 TOMM70 KIT KIT MTOR MTOR PROX1 PROX1 SOX6 SOX6 TBX1 TBX1 MECP2 MECP2 Naca Naca NFATC2 NFATC2 RBM38 RBM38 HDAC4 HDAC4 RBM4 RBM4 LMOD3 LMOD3 ANKRD17 ANKRD17 HDAC3 HDAC3 GSK3B GSK3B TRIP10 TRIP10 FDPS FDPS CTH CTH DKK1 DKK1 SETD3 SETD3 SMARCD3 SMARCD3 FZD7 FZD7 Sik1 Sik1 H0VY77_CAVPO H0VY77_CAVPO ID2 ID2 FBXO22 FBXO22 NKX2-5 NKX2-5 TRIM72 TRIM72 BCL2 BCL2 Ccnd2 Ccnd2 DLL1 DLL1 Yy1 Yy1 OLFM2 OLFM2 ADRB1 ADRB1 MMP14 MMP14 PARP2 PARP2 PI16 PI16 PAK1 PAK1 MYOG MYOG BMPR1A BMPR1A DNMT1 DNMT1 GSK3A GSK3A MYOD1 MYOD1 CCDC142 CCDC142 BMP10 BMP10 HDAC5 HDAC5 RGS2 RGS2 SOD2 SOD2 MDM2 MDM2 LAMB1 LAMB1 CCN3 CCN3 MAMSTR MAMSTR PTBP1 PTBP1 MEF2C MEF2C RBM24 RBM24 MAPK14 MAPK14 AKIRIN2 AKIRIN2 MYF6 MYF6 NFATC3 NFATC3 CCN4 CCN4 EFEMP2 EFEMP2 ANKRD2 ANKRD2 GPER1 GPER1 Foxp1 Foxp1 TCF23 TCF23 CSRP3 CSRP3 WNT3A WNT3A KAT2A KAT2A SHOX2 SHOX2 HAMP HAMP RCAN1 RCAN1 PIN1 PIN1 Eif5a Eif5a PDCD4 PDCD4 DAXX DAXX FOXO4 FOXO4 PLPP7 PLPP7 RGS4 RGS4 BHLHA15 BHLHA15 TNPO2 TNPO2 FGFR2 FGFR2 ZBED6 ZBED6 IGF2 IGF2 TRIM32 TRIM32 EDN1 EDN1 BMPR2 BMPR2 MEGF10 MEGF10 EREG EREG BMP2 BMP2 GREM1 GREM1 CAV3 CAV3 MSX1 MSX1 TARBP2 TARBP2 SHH SHH MED28 MED28 TSHZ3 TSHZ3 IGF1 IGF1 SMYD1 SMYD1 Hopx Hopx ARRB2 ARRB2 EFNB2 EFNB2 ENG ENG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
SIRT1Sirtuin 1. (717 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
DDX39BDExD-box helicase 39B. (428 aa)
MYOCDMyocardin. (976 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (956 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (889 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
MYLK3Myosin light chain kinase 3. (811 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
PRDM6PR/SET domain 6. (367 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1046 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1126 aa)
RBPMS2RNA binding protein, mRNA processing factor 2. (178 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
NRG1Neuregulin 1. (700 aa)
XBP1X-box binding protein 1. (268 aa)
NLNNeurolysin. (704 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
NEU2Neuraminidase 2. (381 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1179 aa)
YBX1YB1. (324 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
PROX1Prospero homeobox 1. (737 aa)
SOX6SRY-box transcription factor 6. (859 aa)
TBX1T-box transcription factor 1. (360 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
NacaNAC-A/B domain-containing protein. (215 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
RBM38RNA binding motif protein 38. (247 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
RBM4RNA binding motif protein 4. (365 aa)
LMOD3Leiomodin 3. (569 aa)
ANKRD17Ankyrin repeat domain 17. (2484 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
TRIP10Thyroid hormone receptor interactor 10. (546 aa)
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (352 aa)
CTHCystathionine gamma-lyase. (399 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (229 aa)
SETD3Protein-histidine N-methyltransferase. (586 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (395 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (569 aa)
Sik1Uncharacterized protein. (777 aa)
H0VY77_CAVPOBHLH domain-containing protein. (131 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
FBXO22F-box protein 22. (380 aa)
NKX2-5NK2 homeobox 5. (303 aa)
TRIM72Tripartite motif containing 72. (477 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
Ccnd2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (607 aa)
Yy1Uncharacterized protein. (195 aa)
OLFM2Olfactomedin 2. (457 aa)
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
MMP14Matrix metallopeptidase 14. (581 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (508 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MYOGMyogenin. (249 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1600 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (318 aa)
CCDC142Coiled-coil domain containing 142. (761 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1137 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
LAMB1Laminin subunit beta 1. (1792 aa)
CCN3Cellular communication network factor 3. (356 aa)
MAMSTRMEF2 activating motif and SAP domain containing transcriptional regulator. (403 aa)
PTBP1Polypyrimidine tract binding protein 1. (557 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
RBM24RNA binding motif protein 24. (236 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
AKIRIN2Akirin 2. (163 aa)
MYF6Myogenic factor 6. (242 aa)
NFATC3Nuclear factor of activated T cells 3. (1060 aa)
CCN4Cellular communication network factor 4. (367 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
ANKRD2Ankyrin repeat domain 2. (328 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
Foxp1Fork-head domain-containing protein. (687 aa)
TCF23Transcription factor 23. (210 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
KAT2ALysine acetyltransferase 2A. (753 aa)
SHOX2Short stature homeobox 2. (320 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
RCAN1Regulator of calcineurin 1. (249 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (166 aa)
Eif5aEukaryotic translation initiation factor 5A. (154 aa)
PDCD4Programmed cell death 4. (469 aa)
DAXXDeath domain associated protein. (756 aa)
FOXO4Forkhead box O4. (505 aa)
PLPP7Phospholipid phosphatase 7 (inactive). (271 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
BHLHA15Basic helix-loop-helix family member a15. (195 aa)
TNPO2Transportin 2. (887 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
ZBED6Zinc finger BED-type containing 6. (979 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
TRIM32Tripartite motif containing 32. (653 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
MEGF10Multiple EGF like domains 10. (1148 aa)
EREGEpiregulin. (164 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GREM1Gremlin. (184 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
MSX1Msh homeobox 1. (304 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
MED28Mediator complex subunit 28. (178 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1081 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
SMYD1SET and MYND domain containing 1. (490 aa)
HopxHomeobox domain-containing protein. (73 aa)
ARRB2Arrestin beta 2. (417 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (295 aa)
ENGEndoglin. (653 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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