45 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	PTGES3	Prostaglandin E synthase 3. (160 aa)
	CHORDC1	Cysteine and histidine rich domain containing 1. (332 aa)
	Rps3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1037 aa)
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	HDAC6	Histone deacetylase 6. (1196 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (496 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (626 aa)
	PPP5C	Serine/threonine-protein phosphatase. (533 aa)
	STIP1	Stress induced phosphoprotein 1. (543 aa)
	TTC4	Tetratricopeptide repeat domain 4. (388 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (303 aa)
	NR3C1	Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (772 aa)
	CYP1A1	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (516 aa)
	CCDC39	Coiled-coil domain containing 39. (678 aa)
	GUCY1B1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (622 aa)
	SLC12A2	Solute carrier family 12 member 2. (1136 aa)
	TRANK1	Tetratricopeptide repeat and ankyrin repeat containing 1. (2905 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (1112 aa)
	PACRG	Parkin coregulated. (241 aa)
	UNC45B	Unc-45 myosin chaperone B. (929 aa)
	Mapt	Microtubule-associated protein. (370 aa)
	PACRGL	Parkin coregulated like. (251 aa)
	USP19	Ubiquitin specific peptidase 19. (1355 aa)
	PPEF2	Serine/threonine-protein phosphatase with EF-hands. (733 aa)
	PTGES3L	Prostaglandin E synthase 3 like. (149 aa)
	AHSA1	Activator of HSP90 ATPase activity 1. (338 aa)
	Hdac8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (415 aa)
	Ahr	Uncharacterized protein. (832 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (828 aa)
	Ahsa2p	Aha1_N domain-containing protein. (331 aa)
	TSC1	TSC complex subunit 1. (1166 aa)
	H0V0N7_CAVPO	Peptidylprolyl isomerase. (204 aa)
	TELO2	Telomere maintenance 2. (737 aa)
	TSC2	TSC complex subunit 2. (1745 aa)
	UNC45A	Unc-45 myosin chaperone A. (944 aa)
	PPID	Peptidylprolyl isomerase D. (370 aa)
	KSR1	Kinase suppressor of ras 1. (879 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (974 aa)
	CDC37	Cell division cycle 37. (378 aa)
	NUP62	Nucleoporin 62. (518 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1018 aa)
	HSF1	Heat shock transcription factor 1. (555 aa)
	ENSCPOP00000029431	Uncharacterized protein. (111 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA1	CDC37	ENSCPOP00000005894	ENSCPOP00000032971	Activator of HSP90 ATPase activity 1.	Cell division cycle 37.	0.686
AHSA1	CHORDC1	ENSCPOP00000005894	ENSCPOP00000029071	Activator of HSP90 ATPase activity 1.	Cysteine and histidine rich domain containing 1.	0.602
AHSA1	H0V0N7_CAVPO	ENSCPOP00000005894	ENSCPOP00000003028	Activator of HSP90 ATPase activity 1.	Peptidylprolyl isomerase.	0.429
AHSA1	PPID	ENSCPOP00000005894	ENSCPOP00000000943	Activator of HSP90 ATPase activity 1.	Peptidylprolyl isomerase D.	0.905
AHSA1	PPP5C	ENSCPOP00000005894	ENSCPOP00000023321	Activator of HSP90 ATPase activity 1.	Serine/threonine-protein phosphatase.	0.564
AHSA1	PTGES3	ENSCPOP00000005894	ENSCPOP00000029406	Activator of HSP90 ATPase activity 1.	Prostaglandin E synthase 3.	0.900
AHSA1	PTGES3L	ENSCPOP00000005894	ENSCPOP00000006122	Activator of HSP90 ATPase activity 1.	Prostaglandin E synthase 3 like.	0.796
AHSA1	STIP1	ENSCPOP00000005894	ENSCPOP00000023163	Activator of HSP90 ATPase activity 1.	Stress induced phosphoprotein 1.	0.965
AHSA1	TSC1	ENSCPOP00000005894	ENSCPOP00000003988	Activator of HSP90 ATPase activity 1.	TSC complex subunit 1.	0.813
AHSA1	TTC4	ENSCPOP00000005894	ENSCPOP00000018560	Activator of HSP90 ATPase activity 1.	Tetratricopeptide repeat domain 4.	0.473
AHSA1	UNC45A	ENSCPOP00000005894	ENSCPOP00000001599	Activator of HSP90 ATPase activity 1.	Unc-45 myosin chaperone A.	0.439
ARNTL	Ahr	ENSCPOP00000023595	ENSCPOP00000004936	Aryl hydrocarbon receptor nuclear translocator like.	Uncharacterized protein.	0.841
ARNTL	HIF1A	ENSCPOP00000023595	ENSCPOP00000004781	Aryl hydrocarbon receptor nuclear translocator like.	Hypoxia inducible factor 1 subunit alpha.	0.860
ARNTL	NR3C1	ENSCPOP00000023595	ENSCPOP00000014391	Aryl hydrocarbon receptor nuclear translocator like.	Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...]	0.545
Ahr	ARNTL	ENSCPOP00000004936	ENSCPOP00000023595	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator like.	0.841
Ahr	CYP1A1	ENSCPOP00000004936	ENSCPOP00000014064	Uncharacterized protein.	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	0.635
Ahr	PTGES3	ENSCPOP00000004936	ENSCPOP00000029406	Uncharacterized protein.	Prostaglandin E synthase 3.	0.992
Ahr	PTGES3L	ENSCPOP00000004936	ENSCPOP00000006122	Uncharacterized protein.	Prostaglandin E synthase 3 like.	0.811
Ahr	TSC1	ENSCPOP00000004936	ENSCPOP00000003988	Uncharacterized protein.	TSC complex subunit 1.	0.876
Ahsa2p	CDC37	ENSCPOP00000004312	ENSCPOP00000032971	Aha1_N domain-containing protein.	Cell division cycle 37.	0.556