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SCN3A SCN3A CHRNA6 CHRNA6 SCN4A SCN4A CHRNA9 CHRNA9 Cacnb2 Cacnb2 Kmt2a Kmt2a P2rx4 P2rx4 SCN4B SCN4B SCN2A SCN2A SCN1A SCN1A CACNG2 CACNG2 BEST2 BEST2 GRIK1 GRIK1 SCN5A SCN5A ATP5IF1 ATP5IF1 Chrnb2 Chrnb2 CHRNA2 CHRNA2 Chrna7 Chrna7 CAV1 CAV1 ENSCPOP00000026472 ENSCPOP00000026472 SCN2B SCN2B SCN3B SCN3B CACNA1C CACNA1C SCN11A SCN11A YWHAH YWHAH CACNA2D1 CACNA2D1 JUN JUN H0WDH3_CAVPO H0WDH3_CAVPO SCN1B SCN1B HCN4 HCN4 CACNA1G CACNA1G CHRNB4 CHRNB4 TRPM4 TRPM4 CHRNA10 CHRNA10 CACNA1A CACNA1A P2rx7 P2rx7 CNGA1 CNGA1 CDKN2A CDKN2A KCNH2 KCNH2 SCN8A SCN8A H0VQQ2_CAVPO H0VQQ2_CAVPO SCN7A SCN7A SCN10A SCN10A LOC100730761 LOC100730761 SCN9A SCN9A CHRNA3 CHRNA3 CHRNA5 CHRNA5 CACNA1H CACNA1H CACNA1I CACNA1I CHRNB3 CHRNB3 CHRNA4 CHRNA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1829 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (465 aa)
Cacnb2SH3 domain-containing protein. (621 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2938 aa)
P2rx4Uncharacterized protein. (343 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (184 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (505 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (103 aa)
Chrnb2Uncharacterized protein. (499 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (519 aa)
Chrna7Uncharacterized protein. (483 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSCPOP00000026472Uncharacterized protein. (286 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (209 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1719 aa)
YWHAH14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
H0WDH3_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (216 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1186 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (489 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (507 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (134 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1144 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1876 aa)
H0VQQ2_CAVPOCyclic nucleotide-binding domain-containing protein. (852 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1520 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1986 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (506 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
CHRNB3Cholinergic receptor nicotinic beta 3 subunit. (463 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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