STRINGSTRING
RAMP2 RAMP2 MEGF10 MEGF10 CSRP1 CSRP1 KDM1A KDM1A Camk2d Camk2d CAV3 CAV3 ENSCPOP00000030888 ENSCPOP00000030888 ADRA1A ADRA1A HOMER1 HOMER1 MEF2A MEF2A ITGB1 ITGB1 IGF1 IGF1 MYH6 MYH6 CASQ2 CASQ2 CASQ1 CASQ1 TCAP TCAP ENSCPOP00000032565 ENSCPOP00000032565 XK XK WDR1 WDR1 EDNRA EDNRA DICER1 DICER1 PRKAR1A PRKAR1A TBX3 TBX3 MYLK3 MYLK3 SGCD SGCD FLII FLII MYOZ1 MYOZ1 ACTN3 ACTN3 H0UZN0_CAVPO H0UZN0_CAVPO Lrrc10 Lrrc10 TMOD3 TMOD3 SMYD3 SMYD3 Krt8 Krt8 H0UYM3_CAVPO H0UYM3_CAVPO MYOCD MYOCD MYOM2 MYOM2 ASB2 ASB2 PDLIM5 PDLIM5 ACTA1 ACTA1 FHOD3 FHOD3 UCHL1 UCHL1 TMOD1 TMOD1 ENG ENG CFLAR CFLAR R3HDM2 R3HDM2 P2RX2 P2RX2 H0VP65_CAVPO H0VP65_CAVPO MET MET LMOD3 LMOD3 SMO SMO NEURL2 NEURL2 R3HDM1 R3HDM1 NFATC2 NFATC2 TMOD2 TMOD2 TMTC3 TMTC3 PROX1 PROX1 HNRNPU HNRNPU PDGFRA PDGFRA MTOR MTOR DNER DNER ZMPSTE24 ZMPSTE24 ACTN2 ACTN2 ATG5 ATG5 GSK3B GSK3B HDAC2 HDAC2 NFATC4 NFATC4 MAP2K4 MAP2K4 MYL9 MYL9 TBX5 TBX5 CHRNB1 CHRNB1 PGM5 PGM5 RYR1 RYR1 WFIKKN1 WFIKKN1 TNNT1 TNNT1 SRF SRF LMNA LMNA H0VYJ9_CAVPO H0VYJ9_CAVPO SYNPO2L SYNPO2L NKX2-5 NKX2-5 KLHL40 KLHL40 CAPN3 CAPN3 COMP COMP TNNT2 TNNT2 LRRC10B LRRC10B MYOG MYOG BMPR1A BMPR1A CACNA2D2 CACNA2D2 KEL KEL BIN1 BIN1 Lox Lox MYOD1 MYOD1 LDB3 LDB3 HEY2 HEY2 BMP10 BMP10 AGT AGT CACNA1S CACNA1S HES1 HES1 TBX18 TBX18 WFIKKN2 WFIKKN2 SELENON SELENON ALPK2 ALPK2 SIX4 SIX4 ADM ADM PTCD2 PTCD2 ADPRHL1 ADPRHL1 Pitx2 Pitx2 NFATC3 NFATC3 LMOD2 LMOD2 CSRP2 CSRP2 ATG7 ATG7 EFEMP2 EFEMP2 TNNT3 TNNT3 SYPL2 SYPL2 TMOD4 TMOD4 ENSCPOP00000024015 ENSCPOP00000024015 CSRP3 CSRP3 LMOD1 LMOD1 ATP2A2 ATP2A2 ACTN4 ACTN4 ENSCPOP00000024842 ENSCPOP00000024842 SHOX2 SHOX2 RCAN1 RCAN1 MYO18B MYO18B MYBPC3 MYBPC3 Cacnb4 Cacnb4 MYH10 MYH10 ANK2 ANK2 NRAP NRAP NEBL NEBL Cav2 Cav2 AFG3L2 AFG3L2 SIX1 SIX1 KRT19 KRT19 NEB NEB SORBS2 SORBS2 ENSCPOP00000028064 ENSCPOP00000028064 BVES BVES ACTN1 ACTN1 ENSCPOP00000028528 ENSCPOP00000028528 WNT10B WNT10B FLNC FLNC BIN3 BIN3 MYL2 MYL2 ACTC1 ACTC1 DYSF DYSF CXADR CXADR MYOF MYOF PPP3CA PPP3CA DMD DMD SDC1 SDC1 CNTNAP1 CNTNAP1 MYH11 MYH11 ALPK3 ALPK3 PPP3CB PPP3CB RIPOR2 RIPOR2 MYPN MYPN TMEM182 TMEM182 MYOZ2 MYOZ2 MYH7 MYH7 SKI SKI STAC3 STAC3 Gata4 Gata4 PDGFRB PDGFRB ISL1 ISL1 FER1L5 FER1L5 Cdk1 Cdk1 KLHL41 KLHL41 ENSCPOP00000029129 ENSCPOP00000029129 POPDC2 POPDC2 FHL2 FHL2 ENSCPOP00000029567 ENSCPOP00000029567 CFL2 CFL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAMP2Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (157 aa)
MEGF10Multiple EGF like domains 10. (1148 aa)
CSRP1Cysteine and glycine rich protein 1. (193 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (865 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
ENSCPOP00000030888Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
HOMER1Homer scaffold protein 1. (329 aa)
MEF2AMyocyte enhancer factor 2A. (517 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
TCAPTitin-cap. (167 aa)
ENSCPOP00000032565Uncharacterized protein. (1114 aa)
XKXK-related protein. (443 aa)
WDR1WD_REPEATS_REGION domain-containing protein. (600 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
TBX3T-box transcription factor 3. (739 aa)
MYLK3Myosin light chain kinase 3. (811 aa)
SGCDSarcoglycan delta. (289 aa)
FLIIFLII actin remodeling protein. (1261 aa)
MYOZ1Myozenin 1. (298 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (889 aa)
H0UZN0_CAVPOUncharacterized protein. (763 aa)
Lrrc10Uncharacterized protein. (279 aa)
TMOD3Tropomodulin 3. (352 aa)
SMYD3SET and MYND domain containing 3. (428 aa)
Krt8IF rod domain-containing protein; Belongs to the intermediate filament family. (474 aa)
H0UYM3_CAVPOUncharacterized protein. (861 aa)
MYOCDMyocardin. (976 aa)
MYOM2Myomesin 2. (1454 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (640 aa)
PDLIM5PDZ and LIM domain 5. (614 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
FHOD3Formin homology 2 domain containing 3. (1505 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (182 aa)
TMOD1Tropomodulin 1. (359 aa)
ENGEndoglin. (653 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (442 aa)
R3HDM2R3H domain containing 2. (1039 aa)
P2RX2P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity); Belongs to the P2X receptor family. (411 aa)
H0VP65_CAVPOIF rod domain-containing protein; Belongs to the intermediate filament family. (403 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1380 aa)
LMOD3Leiomodin 3. (569 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
NEURL2Neuralized E3 ubiquitin protein ligase 2. (285 aa)
R3HDM1R3H domain containing 1. (1127 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
TMOD2Tropomodulin 2. (351 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (914 aa)
PROX1Prospero homeobox 1. (737 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (822 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
DNERDelta/notch like EGF repeat containing. (741 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ACTN2Actinin alpha 2. (894 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
NFATC4Nuclear factor of activated T cells 4. (901 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
MYL9Myosin light chain 9. (172 aa)
TBX5T-box transcription factor 5. (518 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (502 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
RYR1Ryanodine receptor 1. (4554 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (552 aa)
TNNT1Troponin T1, slow skeletal type. (253 aa)
SRFSerum response factor. (461 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (624 aa)
H0VYJ9_CAVPOUncharacterized protein. (1418 aa)
SYNPO2LSynaptopodin 2 like. (975 aa)
NKX2-5NK2 homeobox 5. (303 aa)
KLHL40Kelch like family member 40. (624 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (779 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
TNNT2Uncharacterized protein. (296 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
MYOGMyogenin. (249 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1129 aa)
KELKell metallo-endopeptidase (Kell blood group). (706 aa)
BIN1Bridging integrator 1. (577 aa)
LoxUncharacterized protein. (209 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (318 aa)
LDB3LIM domain binding 3. (709 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (333 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
TBX18T-box transcription factor 18. (606 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (573 aa)
SELENONSelenoprotein N. (573 aa)
ALPK2Alpha kinase 2. (2148 aa)
SIX4SIX homeobox 4. (766 aa)
ADMAdrenomedullin. (182 aa)
PTCD2Pentatricopeptide repeat domain 2. (383 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (354 aa)
Pitx2Homeobox protein. (325 aa)
NFATC3Nuclear factor of activated T cells 3. (1060 aa)
LMOD2Leiomodin 2. (525 aa)
CSRP2Cysteine and glycine rich protein 2. (193 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
TNNT3Troponin T3, fast skeletal type. (276 aa)
SYPL2Synaptophysin like 2. (264 aa)
TMOD4Tropomodulin 4. (345 aa)
ENSCPOP00000024015Uncharacterized protein. (5460 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
LMOD1Leiomodin 1. (595 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ACTN4Actinin alpha 4. (911 aa)
ENSCPOP00000024842Uncharacterized protein. (173 aa)
SHOX2Short stature homeobox 2. (320 aa)
RCAN1Regulator of calcineurin 1. (249 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2559 aa)
MYBPC3Myosin binding protein C, cardiac. (1298 aa)
Cacnb4SH3 domain-containing protein. (519 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
ANK2Ankyrin 2. (3876 aa)
NRAPNebulin related anchoring protein. (1730 aa)
NEBLNebulette. (1000 aa)
Cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (125 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (809 aa)
SIX1SIX homeobox 1. (284 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (397 aa)
NEBNebulin. (7032 aa)
SORBS2Sorbin and SH3 domain containing 2. (1204 aa)
ENSCPOP00000028064IF rod domain-containing protein; Belongs to the intermediate filament family. (393 aa)
BVESBlood vessel epicardial substance. (359 aa)
ACTN1Actinin alpha 1. (914 aa)
ENSCPOP00000028528IF rod domain-containing protein; Belongs to the intermediate filament family. (253 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
FLNCFilamin C. (2726 aa)
BIN3Bridging integrator 3. (253 aa)
MYL2Myosin light chain 2. (167 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
DYSFDysferlin. (2103 aa)
CXADRUncharacterized protein. (356 aa)
MYOFMyoferlin. (2033 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
DMDDystrophin. (3613 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (327 aa)
CNTNAP1Contactin associated protein 1. (1374 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1982 aa)
ALPK3Alpha kinase 3. (1579 aa)
PPP3CBSerine/threonine-protein phosphatase. (531 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1062 aa)
MYPNMyopalladin. (1321 aa)
TMEM182Transmembrane protein 182. (229 aa)
MYOZ2Myozenin 2. (264 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1949 aa)
SKISKI proto-oncogene. (586 aa)
STAC3SH3 and cysteine rich domain 3. (363 aa)
Gata4Uncharacterized protein. (237 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
ISL1ISL LIM homeobox 1. (349 aa)
FER1L5Fer-1 like family member 5. (2020 aa)
Cdk1Protein kinase domain-containing protein. (240 aa)
KLHL41Kelch like family member 41. (606 aa)
ENSCPOP00000029129Protein kinase domain-containing protein. (254 aa)
POPDC2Popeye domain containing 2. (368 aa)
FHL2Four and a half LIM domains 2. (279 aa)
ENSCPOP00000029567IF rod domain-containing protein; Belongs to the intermediate filament family. (456 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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