66 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SGCD	Sarcoglycan delta. (289 aa)
	MYLK3	Myosin light chain kinase 3. (811 aa)
	TBX3	T-box transcription factor 3. (739 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
	Cdk1	Protein kinase domain-containing protein. (240 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
	Gata4	Uncharacterized protein. (237 aa)
	ALPK3	Alpha kinase 3. (1579 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1982 aa)
	MYOCD	Myocardin. (976 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (640 aa)
	FHOD3	Formin homology 2 domain containing 3. (1505 aa)
	CXADR	Uncharacterized protein. (356 aa)
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	MYL2	Myosin light chain 2. (167 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (822 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1380 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	SRF	Serum response factor. (461 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (624 aa)
	H0VYJ9_CAVPO	Uncharacterized protein. (1418 aa)
	NKX2-5	NK2 homeobox 5. (303 aa)
	LRRC10B	Leucine rich repeat containing 10B. (292 aa)
	BMPR1A	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (333 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (477 aa)
	TBX18	T-box transcription factor 18. (606 aa)
	ALPK2	Alpha kinase 2. (2148 aa)
	ADPRHL1	ADP-ribosylhydrolase like 1. (354 aa)
	Pitx2	Homeobox protein. (325 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
	ENSCPOP00000024015	Uncharacterized protein. (5460 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	ENSCPOP00000024842	Uncharacterized protein. (173 aa)
	SHOX2	Short stature homeobox 2. (320 aa)
	MYO18B	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2559 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
	NRAP	Nebulin related anchoring protein. (1730 aa)
	NEBL	Nebulette. (1000 aa)
	NEB	Nebulin. (7032 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1204 aa)
	BVES	Blood vessel epicardial substance. (359 aa)
	PDLIM5	PDZ and LIM domain 5. (614 aa)
	ENSCPOP00000029129	Protein kinase domain-containing protein. (254 aa)
	POPDC2	Popeye domain containing 2. (368 aa)
	FHL2	Four and a half LIM domains 2. (279 aa)
	Camk2d	Protein kinase domain-containing protein. (532 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	ENSCPOP00000030888	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (238 aa)
	ADRA1A	Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
	MEF2A	Myocyte enhancer factor 2A. (517 aa)
	TCAP	Titin-cap. (167 aa)
	ENSCPOP00000032565	Uncharacterized protein. (1114 aa)
	H0UYM3_CAVPO	Uncharacterized protein. (861 aa)
	Lrrc10	Uncharacterized protein. (279 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	ACTN2	ENSCPOP00000009329	ENSCPOP00000012587	Actin alpha cardiac muscle 1.	Actinin alpha 2.	0.791
ACTC1	CAV3	ENSCPOP00000009329	ENSCPOP00000030684	Actin alpha cardiac muscle 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.421
ACTC1	CSRP3	ENSCPOP00000009329	ENSCPOP00000024103	Actin alpha cardiac muscle 1.	Cysteine and glycine rich protein 3.	0.438
ACTC1	ENSCPOP00000024015	ENSCPOP00000009329	ENSCPOP00000024015	Actin alpha cardiac muscle 1.	Uncharacterized protein.	0.554
ACTC1	ENSCPOP00000024842	ENSCPOP00000009329	ENSCPOP00000024842	Actin alpha cardiac muscle 1.	Uncharacterized protein.	0.554
ACTC1	ENSCPOP00000032565	ENSCPOP00000009329	ENSCPOP00000032565	Actin alpha cardiac muscle 1.	Uncharacterized protein.	0.411
ACTC1	GSK3B	ENSCPOP00000009329	ENSCPOP00000012892	Actin alpha cardiac muscle 1.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.408
ACTC1	LMNA	ENSCPOP00000009329	ENSCPOP00000015745	Actin alpha cardiac muscle 1.	Lamin A/C; Belongs to the intermediate filament family.	0.417
ACTC1	MYH10	ENSCPOP00000009329	ENSCPOP00000026167	Actin alpha cardiac muscle 1.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.743
ACTC1	MYH11	ENSCPOP00000009329	ENSCPOP00000007804	Actin alpha cardiac muscle 1.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.765
ACTC1	MYL2	ENSCPOP00000009329	ENSCPOP00000009620	Actin alpha cardiac muscle 1.	Myosin light chain 2.	0.913
ACTC1	MYO18B	ENSCPOP00000009329	ENSCPOP00000025568	Actin alpha cardiac muscle 1.	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.513
ACTC1	PDLIM5	ENSCPOP00000009329	ENSCPOP00000028823	Actin alpha cardiac muscle 1.	PDZ and LIM domain 5.	0.404
ACTN2	ACTC1	ENSCPOP00000012587	ENSCPOP00000009329	Actinin alpha 2.	Actin alpha cardiac muscle 1.	0.791
ACTN2	CAV3	ENSCPOP00000012587	ENSCPOP00000030684	Actinin alpha 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.445
ACTN2	CSRP3	ENSCPOP00000012587	ENSCPOP00000024103	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.824
ACTN2	Camk2d	ENSCPOP00000012587	ENSCPOP00000030575	Actinin alpha 2.	Protein kinase domain-containing protein.	0.826
ACTN2	ENSCPOP00000024015	ENSCPOP00000012587	ENSCPOP00000024015	Actinin alpha 2.	Uncharacterized protein.	0.911
ACTN2	ENSCPOP00000024842	ENSCPOP00000012587	ENSCPOP00000024842	Actinin alpha 2.	Uncharacterized protein.	0.911
ACTN2	ENSCPOP00000032565	ENSCPOP00000012587	ENSCPOP00000032565	Actinin alpha 2.	Uncharacterized protein.	0.703