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PTRHD1 PTRHD1 ARL13B ARL13B FFAR4 FFAR4 PDE6A PDE6A GUCY2D GUCY2D BBS7 BBS7 BBS9 BBS9 LOC100735737 LOC100735737 TTC8 TTC8 SSTR3 SSTR3 RAB8A RAB8A Iqce Iqce EPS15 EPS15 PRPH PRPH TMEM17 TMEM17 GPR157 GPR157 BBS5 BBS5 CLTB CLTB PRCD PRCD DRD1 DRD1 TMEM231 TMEM231 PDE6H PDE6H ENSCPOP00000023917 ENSCPOP00000023917 MOSMO MOSMO GPR37L1 GPR37L1 ENSCPOP00000021870 ENSCPOP00000021870 EHD3 EHD3 Bbs1 Bbs1 Ceacam1 Ceacam1 DRD5 DRD5 MXRA8 MXRA8 TAS2R4 TAS2R4 PDE6G PDE6G PDE6B PDE6B SCNN1A SCNN1A CNGA1 CNGA1 SHANK3 SHANK3 ROM1 ROM1 EFCAB7 EFCAB7 UMOD UMOD PKD2 PKD2 Septin2 Septin2 SMO SMO MCHR1 MCHR1 PHLPP2 PHLPP2 Scnn1d Scnn1d CNGA2 CNGA2 PKD2L1 PKD2L1 CASK CASK SHANK2 SHANK2 EVC EVC EVC2 EVC2 DRD2 DRD2 GPI GPI EHD1 EHD1 PROM1 PROM1 TMEM67 TMEM67 PROM2 PROM2 ADCY3 ADCY3 GNB1 GNB1 CDHR1 CDHR1 LOC100716676 LOC100716676 RHO RHO TSPEAR TSPEAR TXNDC15 TXNDC15 BBS2 BBS2 SNAP29 SNAP29
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ARL13BADP ribosylation factor like GTPase 13B. (382 aa)
FFAR4Free fatty acid receptor 4. (363 aa)
PDE6APhosphodiesterase. (860 aa)
GUCY2DGuanylate cyclase. (1102 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
BBS9Bardet-Biedl syndrome 9. (887 aa)
LOC100735737Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (209 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (432 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
IqceUncharacterized protein. (667 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (935 aa)
PRPHPeripherin; Belongs to the intermediate filament family. (598 aa)
TMEM17Transmembrane protein 17. (198 aa)
GPR157G protein-coupled receptor 157. (330 aa)
BBS5Bardet-Biedl syndrome 5 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] (341 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
PRCDPhotoreceptor disc component. (58 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
TMEM231Transmembrane protein 231. (316 aa)
PDE6HPhosphodiesterase 6H. (83 aa)
ENSCPOP00000023917Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (317 aa)
MOSMOModulator of smoothened. (167 aa)
GPR37L1G protein-coupled receptor 37 like 1. (478 aa)
ENSCPOP00000021870Uncharacterized protein. (70 aa)
EHD3EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
Bbs1BBS1 domain-containing protein. (593 aa)
Ceacam1Uncharacterized protein. (518 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
MXRA8Matrix remodeling associated 8. (410 aa)
TAS2R4Taste receptor type 2. (299 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones (By similarity). (87 aa)
PDE6BPhosphodiesterase. (854 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Belongs to the amilori [...] (680 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (507 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
ROM1Retinal outer segment membrane protein 1. (351 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
UMODUromodulin. (644 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
Septin2Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (361 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
MCHR1Melanin concentrating hormone receptor 1. (355 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1292 aa)
Scnn1dUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (618 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (663 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (760 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1839 aa)
EVCEvC ciliary complex subunit 1. (985 aa)
EVC2EvC ciliary complex subunit 2. (1198 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
EHD1EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (534 aa)
PROM1Prominin 1. (859 aa)
TMEM67Transmembrane protein 67. (1006 aa)
PROM2Prominin 2. (834 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
GNB1Beta-transducin. (340 aa)
CDHR1Cadherin related family member 1. (857 aa)
LOC100716676TPR_REGION domain-containing protein. (567 aa)
RHORhodopsin. (348 aa)
TSPEARThrombospondin type laminin G domain and EAR repeats. (652 aa)
TXNDC15Thioredoxin domain containing 15. (348 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
SNAP29Synaptosome associated protein 29. (255 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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