STRINGSTRING
CPB2 CPB2 PTGER4 PTGER4 PROS1 PROS1 PLAU PLAU PTK2 PTK2 ABCC8 ABCC8 SH2B3 SH2B3 HPSE HPSE UBASH3B UBASH3B TNF TNF MYOZ1 MYOZ1 FGA FGA ALOX12 ALOX12 MYLK MYLK KLKB1 KLKB1 F7 F7 FGF2 FGF2 PDGFB PDGFB MMRN1 MMRN1 ST3GAL4 ST3GAL4 DMTN DMTN VKORC1 VKORC1 Anxa2 Anxa2 CRK CRK APOE APOE DUOX2 DUOX2 DUOX1 DUOX1 CD109 CD109 XBP1 XBP1 FGG FGG CLDN3 CLDN3 FGB FGB ADTRP ADTRP DDR2 DDR2 HBEGF HBEGF EPHB2 EPHB2 CASK CASK ACTA2 ACTA2 PLG PLG MTOR MTOR SRSF6 SRSF6 PDGFRA PDGFRA APOH APOH KNG1 KNG1 PROC PROC F11 F11 ADAMTS18 ADAMTS18 SLC12A2 SLC12A2 FERMT1 FERMT1 ANXA1 ANXA1 THBS1 THBS1 ARFGEF1 ARFGEF1 CD34 CD34 PRKCE PRKCE HRG HRG PRDX2 PRDX2 Insl3 Insl3 PTEN PTEN F12 F12 THBD THBD CLDN4 CLDN4 Ceacam1 Ceacam1 VIL1 VIL1 AJAP1 AJAP1 ALOX5 ALOX5 WFDC1 WFDC1 CLDN19 CLDN19 PHLDB2 PHLDB2 H0UTW7_CAVPO H0UTW7_CAVPO ENSCPOP00000022863 ENSCPOP00000022863 ANXA5 ANXA5 CLDN1 CLDN1 SERPINE1 SERPINE1 CCN4 CCN4 ENSCPOP00000023625 ENSCPOP00000023625 KANK1 KANK1 ENPP4 ENPP4 SERPING1 SERPING1 F2RL1 F2RL1 F2R F2R RREB1 RREB1 SERPINE2 SERPINE2 SMOC2 SMOC2 ABAT ABAT SERPINF2 SERPINF2 C1qtnf6 C1qtnf6 CD36 CD36 PRKG1 PRKG1 PRKCD PRKCD C1QTNF1 C1QTNF1 FOXA2 FOXA2 PTGER3 PTGER3 CXCR4 CXCR4 CAV1 CAV1 NFE2L2 NFE2L2 TSPAN8 TSPAN8 ANO6 ANO6 F2 F2 CLASP1 CLASP1 VEGFB VEGFB TAFA5 TAFA5 Clasp2 Clasp2 CD9 CD9 FERMT2 FERMT2 SMAD3 SMAD3 CLEC7A CLEC7A ITGB1 ITGB1 PDGFA PDGFA TNFRSF12A TNFRSF12A WNT4 WNT4 EMILIN2 EMILIN2 TBXA2R TBXA2R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CPB2Carboxypeptidase B2. (423 aa)
PTGER4Prostaglandin E2 receptor 4; Belongs to the G-protein coupled receptor 1 family. (487 aa)
PROS1Protein S. (675 aa)
PLAUPlasminogen activator, urokinase. (434 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
ABCC8ATP binding cassette subfamily C member 8. (1549 aa)
SH2B3SH2B adaptor protein 3. (557 aa)
HPSEHeparanase. (526 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (638 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
MYOZ1Myozenin 1. (298 aa)
FGAFibrinogen alpha chain. (775 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (656 aa)
MYLKMyosin light chain kinase. (1959 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (504 aa)
F7Coagulation factor VII. (441 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
MMRN1Multimerin 1. (1215 aa)
ST3GAL4ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (441 aa)
DMTNDematin actin binding protein. (371 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1. (163 aa)
Anxa2Annexin. (339 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
DUOX2Dual oxidase 2. (1517 aa)
DUOX1Dual oxidase 1. (1551 aa)
CD109CD109 molecule. (1402 aa)
XBP1X-box binding protein 1. (268 aa)
FGGFibrinogen gamma chain. (445 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
FGBFibrinogen beta chain. (479 aa)
ADTRPAndrogen dependent TFPI regulating protein. (223 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (854 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
EPHB2EPH receptor B2. (949 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SRSF6Serine and arginine rich splicing factor 6. (318 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
APOHApolipoprotein H. (235 aa)
KNG1Kininogen 1. (625 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (464 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (650 aa)
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18. (1219 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
FERMT1Fermitin family member 1. (676 aa)
ANXA1Annexin. (346 aa)
THBS1Thrombospondin 1. (1163 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1817 aa)
CD34CD34 molecule. (389 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
HRGHistidine rich glycoprotein. (467 aa)
PRDX2Peroxiredoxin 2. (198 aa)
Insl3IlGF domain-containing protein. (132 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (617 aa)
THBDThrombomodulin. (534 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
Ceacam1Uncharacterized protein. (518 aa)
VIL1Villin 1. (827 aa)
AJAP1Adherens junctions associated protein 1. (410 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
WFDC1WAP four-disulfide core domain 1. (211 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1345 aa)
H0UTW7_CAVPOSERPIN domain-containing protein; Belongs to the serpin family. (93 aa)
ENSCPOP00000022863SEA domain-containing protein. (251 aa)
ANXA5Annexin. (318 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (476 aa)
CCN4Cellular communication network factor 4. (367 aa)
ENSCPOP00000023625Uncharacterized protein. (104 aa)
KANK1KN motif and ankyrin repeat domains 1. (1353 aa)
ENPP4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (478 aa)
SERPING1SERPIN domain-containing protein; Belongs to the serpin family. (578 aa)
F2RL1F2R like trypsin receptor 1. (399 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
RREB1Ras responsive element binding protein 1. (1738 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
SMOC2SPARC related modular calcium binding 2. (447 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
C1qtnf6C1q domain-containing protein. (101 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
C1QTNF1C1q and TNF related 1. (281 aa)
FOXA2Forkhead box A2. (459 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (591 aa)
TSPAN8Tetraspanin. (237 aa)
ANO6Anoctamin. (922 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (664 aa)
CLASP1Cytoplasmic linker associated protein 1. (1524 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (206 aa)
TAFA5TAFA chemokine like family member 5. (125 aa)
Clasp2Uncharacterized protein. (1497 aa)
CD9Tetraspanin. (227 aa)
FERMT2Fermitin family member 2. (706 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CLEC7AC-type lectin domain containing 7A. (204 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
TNFRSF12ATNF receptor superfamily member 12A. (129 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
EMILIN2Elastin microfibril interfacer 2. (1042 aa)
TBXA2RThromboxane A2 receptor. (347 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (30%) [HD]