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| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (229 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (294 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa) |
| | DGAT2 | Diacylglycerol O-acyltransferase 2. (388 aa) |
| | COMT | Catechol-O-methyltransferase. (292 aa) |
| | SUPT20H | SPT20 homolog, SAGA complex component. (781 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (828 aa) |
| | IRS1 | Insulin receptor substrate 1. (1243 aa) |
| | DGAT1 | O-acyltransferase. (493 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | LOC100725465 | FABP domain-containing protein. (127 aa) |
| | ADCYAP1R1 | ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (524 aa) |
| | ABCG4 | ATP binding cassette subfamily G member 4. (646 aa) |
| | GUCA2B | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. (113 aa) |
| | PTH1R | Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (590 aa) |
| | PPP4R3A | Protein phosphatase 4 regulatory subunit 3A. (733 aa) |
| | CYP7A1 | Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (496 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (474 aa) |
| | STAR | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | ACTN3 | Actinin alpha 3 (gene/pseudogene). (889 aa) |
| | SORBS1 | Sorbin and SH3 domain containing 1. (933 aa) |
| | C1QTNF2 | C1q and TNF related 2. (318 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (364 aa) |
| | LOC100725733 | FABP domain-containing protein. (127 aa) |
| | P2RY6 | Pyrimidinergic receptor P2Y6. (328 aa) |
| | ENSCPOP00000029800 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (179 aa) |
| | GCK | Phosphotransferase. (414 aa) |
| | CLYBL | Citrate lyase beta like. (343 aa) |
| | PID1 | Phosphotyrosine interaction domain containing 1. (217 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3. (633 aa) |
| | IGF2 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa) |
| | HNF1A | HNF1 homeobox A. (628 aa) |
| | Dab2 | PID domain-containing protein. (766 aa) |
| | ENSCPOP00000027789 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (122 aa) |
| | SREBF2 | Sterol regulatory element binding transcription factor 2. (1149 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | SREBF1 | Sterol regulatory element binding transcription factor 1. (1155 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (484 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (839 aa) |
| | PPARA | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and [...] (467 aa) |
| | H0VCZ7_CAVPO | Fork-head domain-containing protein. (548 aa) |
| | LOC100726004 | FABP domain-containing protein. (127 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | GUCA1B | Guanylate cyclase activator 1B. (200 aa) |
| | ABCD2 | ATP binding cassette subfamily D member 2. (740 aa) |
| | MLXIPL | MLX interacting protein like. (854 aa) |
| | Ces1d | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa) |
| | PPP4R3B | Protein phosphatase 4 regulatory subunit 3B. (802 aa) |
| | LPGAT1 | Lysophosphatidylglycerol acyltransferase 1. (370 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (440 aa) |
| | ABCD1 | ATP binding cassette subfamily D member 1. (723 aa) |
| | PLA2G3 | Phospholipase A2 group III. (645 aa) |
| | LOC100735918 | NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1371 aa) |
| | NNMT | Nicotinamide N-methyltransferase. (264 aa) |
| | RGN | Regucalcin. (299 aa) |
| | GHSR | Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (302 aa) |
| | APOA5 | Apolipoprotein A5. (429 aa) |
| | BMP6 | Bone morphogenetic protein 6. (505 aa) |
| | SEC14L2 | Uncharacterized protein. (403 aa) |
| | ANXA1 | Annexin. (346 aa) |
| | ENSCPOP00000027395 | Uncharacterized protein. (56 aa) |
| | WDR5 | WD repeat domain 5. (334 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa) |
| | ADIPOQ | Adiponectin, C1Q and collagen domain containing. (247 aa) |
| | ENSCPOP00000026628 | Uncharacterized protein. (100 aa) |
| | SNCA | Alpha-synuclein; Belongs to the synuclein family. (140 aa) |
| | CPT1A | Carnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (772 aa) |
| | STARD4 | StAR related lipid transfer domain containing 4. (208 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa) |
| | CD74 | CD74 molecule. (280 aa) |
| | FGF1 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa) |
| | LOC106026223 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (181 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (443 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | ENSCPOP00000024929 | SCP2 domain-containing protein. (143 aa) |
| | ENSCPOP00000024925 | COesterase domain-containing protein. (295 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa) |
| | KAT2A | Lysine acetyltransferase 2A. (753 aa) |
| | Pmaip1 | Uncharacterized protein. (102 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa) |
| | ADORA2B | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (221 aa) |
| | MLYCD | Malonyl-CoA decarboxylase. (488 aa) |
| | SIRT1 | Sirtuin 1. (717 aa) |
| | Rdh10 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (285 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | PLCD1 | Phosphoinositide phospholipase C. (755 aa) |
| | MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (322 aa) |
| | SLC25A12 | Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa) |
| | LOC100721835 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa) |
| | Cd244 | Ig-like domain-containing protein. (345 aa) |
| | Il4 | Interleukin-4. (144 aa) |
| | PLIN5 | Perilipin; Belongs to the perilipin family. (458 aa) |
| | PPP1R3E | Protein phosphatase 1 regulatory subunit 3E. (279 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ESRRB | Estrogen related receptor beta. (454 aa) |
| | AVPR1B | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (422 aa) |
| | Ncs1 | Uncharacterized protein. (168 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa) |
| | LOC100725073 | PID domain-containing protein. (745 aa) |
| | LOC100717473 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa) |
| | PLA2G4A | Phospholipase A2. (749 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (350 aa) |
| | BEND3 | BEN domain containing 3. (828 aa) |
| | ENSCPOP00000022046 | Thiolase_N domain-containing protein. (103 aa) |
| | PPARGC1A | PPARG coactivator 1 alpha. (796 aa) |
| | POU1F1 | POU domain protein. (316 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (477 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa) |
| | LOC100720852 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (181 aa) |
| | EPM2AIP1 | EPM2A interacting protein 1. (608 aa) |
| | APOC2 | Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. (100 aa) |
| | SCAP | SREBF chaperone. (1260 aa) |
| | ZBTB20 | Zinc finger and BTB domain containing 20. (741 aa) |
| | SLC45A3 | Solute carrier family 45 member 3. (521 aa) |
| | HRH1 | Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (482 aa) |
| | NUCB2 | Nucleobindin 2. (420 aa) |
| | LOC100718644 | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (207 aa) |
| | Slc4a4 | Anion exchange protein. (1035 aa) |
| | GUCA2A | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. (119 aa) |
| | APOA1 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa) |
| | HTR2A | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (463 aa) |
| | LOC100730472 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa) |
| | BCL2L1 | BCL2 like 1. (233 aa) |
| | VCP | Valosin containing protein; Belongs to the AAA ATPase family. (806 aa) |
| | TAZ | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa) |
| | H0VW66_CAVPO | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (306 aa) |
| | ARPP19 | cAMP regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (140 aa) |
| | GCG | Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa) |
| | MID1IP1 | MID1 interacting protein 1. (144 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa) |
| | H0VUM1_CAVPO | Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (146 aa) |
| | H0VU94_CAVPO | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa) |
| | COX2 | Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (227 aa) |
| | Guca1a | Uncharacterized protein. (200 aa) |
| | Lhcgr | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (691 aa) |
| | GPT | Glutamic--pyruvic transaminase. (496 aa) |
| | FDPS | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (352 aa) |
| | ABCG1 | ATP binding cassette subfamily G member 1. (666 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (611 aa) |
