STRINGSTRING
NAT10 NAT10 LONP1 LONP1 PTGES3 PTGES3 HNRNPA2B1 HNRNPA2B1 CDK2AP1 CDK2AP1 LOC100725824 LOC100725824 NCOA2 NCOA2 NHEJ1 NHEJ1 CDT1 CDT1 PAXX PAXX SMARCA4 SMARCA4 NABP2 NABP2 SMG6 SMG6 Rtel1 Rtel1 RAD51 RAD51 ACD ACD PCNA PCNA FANCI FANCI POLG2 POLG2 FANCD2 FANCD2 HSP90AB1 HSP90AB1 Hsp90aa1 Hsp90aa1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1030 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (1003 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
HNRNPA2B1Heterogeneous nuclear ribonucleoprotein A2/B1. (369 aa)
CDK2AP1Cyclin dependent kinase 2 associated protein 1. (133 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
NCOA2Nuclear receptor coactivator. (1462 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
PAXXPAXX non-homologous end joining factor. (206 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1636 aa)
NABP2Nucleic acid binding protein 2. (227 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1420 aa)
Rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (421 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
FANCIFA complementation group I. (1313 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (482 aa)
FANCD2FA complementation group D2. (1448 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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