STRINGSTRING
MARCKSL1 MARCKSL1 P2ry12 P2ry12 SLC24A2 SLC24A2 ANO6 ANO6 GPM6A GPM6A RYR3 RYR3 RYR2 RYR2 FKBP1B FKBP1B TRPV4 TRPV4 GRIN2D GRIN2D TRPC7 TRPC7 AFG3L2 AFG3L2 BHLHA15 BHLHA15 TRDN TRDN TMEM37 TMEM37 GRIN1 GRIN1 Cacnb4 Cacnb4 STIM1 STIM1 Fkbp1a Fkbp1a TMEM38B TMEM38B TSPOAP1 TSPOAP1 LOC100714922 LOC100714922 PSEN1 PSEN1 F2R F2R WNT3A WNT3A ATP2A2 ATP2A2 ENSCPOP00000023749 ENSCPOP00000023749 ATP2B4 ATP2B4 CACNG3 CACNG3 MCOLN3 MCOLN3 CACNG1 CACNG1 CACNB1 CACNB1 LOC100714756 LOC100714756 CACNA1C CACNA1C ANXA5 ANXA5 PANX1 PANX1 ATP2B1 ATP2B1 ORAI3 ORAI3 CACNG6 CACNG6 CACNA2D1 CACNA2D1 ANXA6 ANXA6 CACNA1S CACNA1S TMEM38A TMEM38A CACNA1G CACNA1G TRPM4 TRPM4 TRPC6 TRPC6 CNR1 CNR1 IBTK IBTK CACNA1A CACNA1A ITPR3 ITPR3 CACNA2D2 CACNA2D2 ORAI1 ORAI1 H0W649_CAVPO H0W649_CAVPO PKDREJ PKDREJ H0W5R9_CAVPO H0W5R9_CAVPO P2rx7 P2rx7 CACNA1F CACNA1F XCR1 XCR1 ATP2B2 ATP2B2 GP9 GP9 ATP2C2 ATP2C2 HRH1 HRH1 CHERP CHERP CACNG4 CACNG4 GRM7 GRM7 GP1BB GP1BB OPRM1 OPRM1 H0VXJ2_CAVPO H0VXJ2_CAVPO H0VVJ6_CAVPO H0VVJ6_CAVPO TRPM2 TRPM2 RYR1 RYR1 MCU MCU EDNRB EDNRB GLP1R GLP1R ITGAV ITGAV TMC2 TMC2 CACNG7 CACNG7 TRPV3 TRPV3 MCUR1 MCUR1 CACNA1E CACNA1E PKD2 PKD2 TMCO1 TMCO1 SLC24A1 SLC24A1 GRIN2A GRIN2A TRPC5 TRPC5 PKD2L2 PKD2L2 FAM155A FAM155A DDIT3 DDIT3 TRPV2 TRPV2 CATSPER3 CATSPER3 ITPR2 ITPR2 CACNA1H CACNA1H SLC35G1 SLC35G1 STOML2 STOML2 SLC24A3 SLC24A3 CACNA1I CACNA1I GRIN3B GRIN3B TMEM165 TMEM165 Trpc4 Trpc4 CACHD1 CACHD1 Trpa1 Trpa1 LETM1 LETM1 TRPM6 TRPM6 SLC25A23 SLC25A23 CALHM1 CALHM1 PKD2L1 PKD2L1 SLC24A5 SLC24A5 SLC24A4 SLC24A4 TRPM5 TRPM5 TRPV1 TRPV1 SLC8A2 SLC8A2 MCOLN1 MCOLN1 MICU3 MICU3 DRD2 DRD2 CACNA2D3 CACNA2D3 ERC1 ERC1 RASA3 RASA3 ATP2A3 ATP2A3 ERO1A ERO1A ASPH ASPH GAS6 GAS6 MCOLN2 MCOLN2 GRIN3A GRIN3A Anxa2 Anxa2 GRIN2B GRIN2B OPA1 OPA1 Cacnb2 Cacnb2 Trpm8 Trpm8 TPCN1 TPCN1 CCL21 CCL21 TRPM7 TRPM7 FGF2 FGF2 MICU2 MICU2 CACNA2D4 CACNA2D4 NOL3 NOL3 SLC8B1 SLC8B1 EDNRA EDNRA CACNA1B CACNA1B P2rx4 P2rx4 MAIP1 MAIP1 STIM2 STIM2 CACNB3 CACNB3 PKD1 PKD1 TRPC1 TRPC1 TMC1 TMC1 CCL19 CCL19 TPCN2 TPCN2 CACNG2 CACNG2 PAWR PAWR SLC8A1 SLC8A1 PLCG2 PLCG2 Vdac1 Vdac1 PTPRC PTPRC EDN1 EDN1 SLC8A3 SLC8A3 ENSCPOP00000029147 ENSCPOP00000029147 NALCN NALCN Mcub Mcub FAM155B FAM155B ATP2C1 ATP2C1 ORAI2 ORAI2 HTR2C HTR2C SMDT1 SMDT1 ITPR1 ITPR1 ATP2B3 ATP2B3 LOC100735187 LOC100735187 Ncs1 Ncs1 BAX BAX ANXA9 ANXA9 CACNA1D CACNA1D SLC25A25 SLC25A25 CDK5 CDK5 HTR2A HTR2A TRPV5 TRPV5 ATP2A1 ATP2A1 TRPV6 TRPV6 MICU1 MICU1 GRIN2C GRIN2C TRPC3 TRPC3 BAK1 BAK1 ASIC1 ASIC1 HTR2B HTR2B LOC100716672 LOC100716672 Faslg Faslg
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MARCKSL1MARCKS like 1. (238 aa)
P2ry12Uncharacterized protein. (114 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (705 aa)
ANO6Anoctamin. (922 aa)
GPM6AGlycoprotein M6A. (278 aa)
RYR3Ryanodine receptor 3. (4843 aa)
RYR2Ryanodine receptor 2. (4910 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
TRPC7Transient receptor potential cation channel subfamily C member 7; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
AFG3L2AFG3 like matrix AAA peptidase subunit 2. (809 aa)
BHLHA15Basic helix-loop-helix family member a15. (195 aa)
TRDNTriadin. (682 aa)
TMEM37Transmembrane protein 37. (197 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
Cacnb4SH3 domain-containing protein. (519 aa)
STIM1Stromal interaction molecule 1. (713 aa)
Fkbp1aPeptidylprolyl isomerase. (108 aa)
TMEM38BTransmembrane protein 38B. (287 aa)
TSPOAP1TSPO associated protein 1. (1837 aa)
LOC100714922Ion_trans domain-containing protein. (685 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
MCOLN3Mucolipin 3. (553 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (641 aa)
LOC100714756SCY domain-containing protein. (114 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
ANXA5Annexin. (318 aa)
PANX1Pannexin; Structural component of the gap junctions and the hemichannels. (427 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
ORAI3ORAI calcium release-activated calcium modulator 3. (297 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (257 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
ANXA6Annexin. (753 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
TMEM38ATransmembrane protein 38A. (298 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
TRPC6Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (934 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
IBTKInhibitor of Bruton tyrosine kinase. (1284 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1129 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (302 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
PKDREJPolycystin family receptor for egg jelly. (2029 aa)
H0W5R9_CAVPOUncharacterized protein. (1527 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
GP9Glycoprotein IX platelet. (181 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (945 aa)
HRH1Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (482 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (934 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (212 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP- bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell ty [...] (416 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
H0VVJ6_CAVPOUncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (1247 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1502 aa)
RYR1Ryanodine receptor 1. (4554 aa)
MCUMitochondrial calcium uniporter. (344 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
TMC2Transmembrane channel-like protein. (868 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family. (789 aa)
MCUR1Mitochondrial calcium uniporter regulator 1. (305 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
TMCO1Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family. (188 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1180 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (621 aa)
FAM155AFamily with sequence similarity 155 member A. (277 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (720 aa)
CATSPER3Cation channel sperm associated 3. (380 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
SLC35G1Solute carrier family 35 member G1. (370 aa)
STOML2Stomatin like 2. (356 aa)
SLC24A3Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (596 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (845 aa)
TMEM165GDT1 family protein. (324 aa)
Trpc4Transient receptor potential channel 4 alpha; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
CACHD1Cache domain containing 1. (1272 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (736 aa)
TRPM6Transient receptor potential cation channel subfamily M member 6. (1902 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (469 aa)
CALHM1Calcium homeostasis modulator 1. (344 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (760 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (605 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1159 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
MCOLN1Mucolipin 1. (582 aa)
MICU3Mitochondrial calcium uptake family member 3. (442 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (991 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1116 aa)
RASA3RAS p21 protein activator 3. (833 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1028 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (425 aa)
ASPHAspartate beta-hydroxylase. (644 aa)
GAS6Growth arrest specific 6. (678 aa)
MCOLN2Mucolipin 2. (540 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
Anxa2Annexin. (339 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
OPA1OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (942 aa)
Cacnb2SH3 domain-containing protein. (621 aa)
Trpm8Transient potential cation channel subfamily M member 8. (1104 aa)
TPCN1Two pore channel 1. (817 aa)
CCL21C-C motif chemokine ligand 21. (126 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1754 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (114 aa)
MICU2Mitochondrial calcium uptake 2. (432 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1101 aa)
NOL3Nucleolar protein 3. (207 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (580 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2270 aa)
P2rx4Uncharacterized protein. (343 aa)
MAIP1Matrix AAA peptidase interacting protein 1. (273 aa)
STIM2Stromal interaction molecule 2. (742 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (810 aa)
TMC1Transmembrane channel-like protein. (761 aa)
CCL19C-C motif chemokine. (107 aa)
TPCN2Two pore channel 2. (752 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
PAWRPro-apoptotic WT1 regulator. (307 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
Vdac1Uncharacterized protein. (283 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1307 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
NALCNSodium leak channel, non-selective. (1738 aa)
McubMCU domain-containing protein. (195 aa)
FAM155BFamily with sequence similarity 155 member B. (418 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (977 aa)
ORAI2ORAI calcium release-activated calcium modulator 2. (307 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
SMDT1Single-pass membrane protein with aspartate rich tail 1. (107 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1226 aa)
LOC100735187C-C motif chemokine. (93 aa)
Ncs1Uncharacterized protein. (168 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
ANXA9Annexin. (345 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
SLC25A25Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (506 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (729 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (767 aa)
MICU1Mitochondrial calcium uptake 1. (483 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
TRPC3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (849 aa)
BAK1BCL2 antagonist/killer 1. (214 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (480 aa)
LOC100716672G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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