STRINGSTRING
Gata4 Gata4 SIN3A SIN3A PRKAA1 PRKAA1 IGF1R IGF1R HIF1A HIF1A SLC29A1 SLC29A1 PTPRN PTPRN GPER1 GPER1 ZNF236 ZNF236 ENSCPOP00000024451 ENSCPOP00000024451 CCDC186 CCDC186 DICER1 DICER1 SERPINF1 SERPINF1 MYC MYC RACK1 RACK1 GCLC GCLC PDK3 PDK3 SLC12A6 SLC12A6 XBP1 XBP1 NFKB1 NFKB1 AACS AACS GAS6 GAS6 POLG POLG HNF1A HNF1A ADCY8 ADCY8 VCAM1 VCAM1 PCK1 PCK1 RAB34 RAB34 NOX4 NOX4 FKBP1B FKBP1B AGER AGER ERN1 ERN1 RAB11FIP2 RAB11FIP2 CPB2 CPB2 MAP2K3 MAP2K3 Selenot Selenot MEN1 MEN1 PPP3CA PPP3CA NPTX1 NPTX1 PRKAA2 PRKAA2 MLXIPL MLXIPL UCP2 UCP2 PCK2 PCK2 TJP1 TJP1 GHRHR GHRHR TH TH RBM4 RBM4 MAP2K4 MAP2K4 SLC2A5 SLC2A5 MAPK13 MAPK13 OGT OGT PRKCA PRKCA Cltrn Cltrn SRF SRF Lin28a Lin28a CYBA CYBA CALCRL CALCRL TWNK TWNK PIK3CA PIK3CA SMAD4 SMAD4 TRA2B TRA2B PRKCB PRKCB CYP7A1 CYP7A1 KCNB1 KCNB1 LEP LEP SLC26A6 SLC26A6 ENSCPOP00000032219 ENSCPOP00000032219 Prkaca Prkaca KEAP1 KEAP1 MAP2K7 MAP2K7 ZBTB20 ZBTB20 Foxo3 Foxo3 Sox4 Sox4 GRIK5 GRIK5 LOC100723124 LOC100723124 ENDOG ENDOG RAB11FIP5 RAB11FIP5 PAX2 PAX2 RAB11B RAB11B GJB6 GJB6 MAP2K6 MAP2K6 UNC13B UNC13B KAT5 KAT5 RPS6KA2 RPS6KA2 AQP4 AQP4 PLCB1 PLCB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Gata4Uncharacterized protein. (237 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (461 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (955 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ZNF236Zinc finger protein 236. (1823 aa)
ENSCPOP00000024451Uncharacterized protein. (153 aa)
CCDC186Coiled-coil domain containing 186. (775 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (639 aa)
PDK3Protein-serine/threonine kinase. (415 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
XBP1X-box binding protein 1. (268 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
AACSAcetoacetyl-CoA synthetase. (672 aa)
GAS6Growth arrest specific 6. (678 aa)
POLGDNA polymerase gamma, catalytic subunit. (1206 aa)
HNF1AHNF1 homeobox A. (628 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
RAB34RAB34, member RAS oncogene family. (259 aa)
NOX4NADPH oxidase 4. (551 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (974 aa)
RAB11FIP2RAB11 family interacting protein 2. (523 aa)
CPB2Carboxypeptidase B2. (423 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
SelenotSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (189 aa)
MEN1Menin 1. (615 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
NPTX1Neuronal pentraxin 1. (432 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MLXIPLMLX interacting protein like. (854 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (652 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (422 aa)
THTyrosine hydroxylase. (498 aa)
RBM4RNA binding motif protein 4. (365 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
SLC2A5Solute carrier family 2 member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
CltrnCollectrin domain-containing protein. (222 aa)
SRFSerum response factor. (461 aa)
Lin28aCCHC-type domain-containing protein. (147 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (189 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
TWNKTwinkle mtDNA helicase. (670 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TRA2BTransformer 2 beta homolog. (268 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (496 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
SLC26A6STAS domain-containing protein. (725 aa)
ENSCPOP00000032219Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (121 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
KEAP1Kelch like ECH associated protein 1. (411 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (459 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
Foxo3Forkhead box O3. (660 aa)
Sox4HMG box domain-containing protein. (227 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (892 aa)
LOC100723124CCHC-type domain-containing protein. (209 aa)
ENDOGEndonuclease. (299 aa)
RAB11FIP5RAB11 family interacting protein 5. (636 aa)
PAX2Paired box 2. (393 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
UNC13BUnc-13 homolog B. (1959 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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