STRINGSTRING
HMGCS1 HMGCS1 H0VU94_CAVPO H0VU94_CAVPO Ces1d Ces1d CDH13 CDH13 SYK SYK CD81 CD81 NPC1 NPC1 LPL LPL PPARG PPARG LOC100730472 LOC100730472 ITGB1 ITGB1 LOC100721835 LOC100721835 CD9 CD9 SOCS5 SOCS5 FCER1G FCER1G SREBF2 SREBF2 CD36 CD36 ENSCPOP00000024925 ENSCPOP00000024925 LOC100717473 LOC100717473
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
H0VU94_CAVPOCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
Ces1dCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
CDH13Cadherin 13. (713 aa)
SYKTyrosine-protein kinase. (579 aa)
CD81Tetraspanin. (236 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (495 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
LOC100730472Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
LOC100721835Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
CD9Tetraspanin. (227 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functi [...] (86 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1149 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ENSCPOP00000024925COesterase domain-containing protein. (295 aa)
LOC100717473Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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