STRINGSTRING
POT1 POT1 TERF2 TERF2 SMPD3 SMPD3 Pclaf Pclaf VCP VCP POLI POLI PTGES3 PTGES3 TK1 TK1 CDKN2D CDKN2D POLH POLH PINX1 PINX1 GAR1 GAR1 NOP10 NOP10 ZBTB1 ZBTB1 LOC100725824 LOC100725824 Pold4 Pold4 POLD1 POLD1 Lox Lox REV3L REV3L POLD2 POLD2 MAD2L2 MAD2L2 Hrob Hrob TREX1 TREX1 SPRTN SPRTN TERT TERT H0VSI3_CAVPO H0VSI3_CAVPO DTL DTL POLM POLM LIG4 LIG4 PARP10 PARP10 POLE POLE LIG3 LIG3 WRNIP1 WRNIP1 SPHK1 SPHK1 REV1 REV1 ACD ACD POLB POLB TERF1 TERF1 PCNA PCNA DKC1 DKC1 POLG POLG POLG2 POLG2 Pold3 Pold3 POLL POLL POLE2 POLE2 Lig1 Lig1 HSP90AB1 HSP90AB1 TELO2 TELO2 POLDIP2 POLDIP2 WRN WRN PRIMPOL PRIMPOL WRAP53 WRAP53 DNTT DNTT SPATA22 SPATA22 Rad50 Rad50 POLA1 POLA1 Hsp90aa1 Hsp90aa1 Pola2 Pola2 POLN POLN TEP1 TEP1 POLK POLK SIRT1 SIRT1 PHB PHB RPA1 RPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POT1Protection of telomeres 1. (652 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
PclafPAF domain-containing protein. (112 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
POLIDNA polymerase iota. (662 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
TK1Thymidine kinase. (233 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
POLHDNA polymerase eta. (712 aa)
PINX1PIN2 (TERF1) interacting telomerase inhibitor 1. (325 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (222 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
ZBTB1Zinc finger and BTB domain containing 1. (712 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
Pold4Uncharacterized protein. (107 aa)
POLD1DNA polymerase. (1134 aa)
LoxUncharacterized protein. (209 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (2940 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
HrobUncharacterized protein. (591 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
SPRTNSprT-like N-terminal domain. (481 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1018 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (734 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (485 aa)
LIG4DNA ligase. (911 aa)
PARP10Poly [ADP-ribose] polymerase. (945 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
LIG3DNA ligase. (1012 aa)
WRNIP1WRN helicase interacting protein 1. (568 aa)
SPHK1Sphingosine kinase 1. (386 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (421 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
DKC1Dyskerin pseudouridine synthase 1. (513 aa)
POLGDNA polymerase gamma, catalytic subunit. (1206 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (482 aa)
Pold3Uncharacterized protein. (466 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
Lig1DNA ligase. (909 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
TELO2Telomere maintenance 2. (737 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
WRNWRN RecQ like helicase. (1462 aa)
PRIMPOLPrimase and DNA directed polymerase. (547 aa)
WRAP53WD repeat containing antisense to TP53. (541 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (502 aa)
SPATA22Spermatogenesis associated 22. (363 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
POLA1DNA polymerase. (1467 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
POLNDNA polymerase nu. (860 aa)
TEP1Telomerase associated protein 1. (2511 aa)
POLKDNA polymerase kappa. (540 aa)
SIRT1Sirtuin 1. (717 aa)
PHBProhibitin. (272 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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