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| | LOC100714967 | Ribonuclease A E1; Belongs to the pancreatic ribonuclease family. (156 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7. (285 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (916 aa) |
| | ELAC1 | ElaC ribonuclease Z 1. (363 aa) |
| | ENSCPOP00000023532 | XRN_N domain-containing protein. (103 aa) |
| | PLD6 | Phospholipase D family member 6. (225 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | Dclre1b | Lactamase_B domain-containing protein. (190 aa) |
| | EXOSC9 | Exosome component 9. (439 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1405 aa) |
| | POLR3K | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa) |
| | TOE1 | Target of EGR1, exonuclease. (509 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa) |
| | DIS3 | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (987 aa) |
| | EXO5 | Exonuclease 5. (373 aa) |
| | ENSCPOP00000025543 | AAA_12 domain-containing protein. (243 aa) |
| | DNASE1L3 | Deoxyribonuclease; Belongs to the DNase I family. (302 aa) |
| | DNASE1L2 | Deoxyribonuclease; Belongs to the DNase I family. (278 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6. (534 aa) |
| | RPP40 | Ribonuclease P/MRP subunit p40. (363 aa) |
| | ENDOU | Endonuclease, poly(U) specific. (411 aa) |
| | ERI2 | ERI1 exoribonuclease family member 2. (687 aa) |
| | ENSCPOP00000026667 | Uncharacterized protein. (62 aa) |
| | ABT1 | Activator of basal transcription 1. (269 aa) |
| | ENSCPOP00000026818 | Uncharacterized protein. (143 aa) |
| | ENSCPOP00000027661 | Uncharacterized protein. (177 aa) |
| | NUDT21 | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (223 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (371 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (857 aa) |
| | LOC100715543 | DEAD-box helicase 1. (502 aa) |
| | Rps3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | RIDA | Reactive intermediate imine deaminase A homolog. (137 aa) |
| | EXOSC2 | Exosome component 2. (293 aa) |
| | CPSF4 | Cleavage and polyadenylation specific factor 4. (244 aa) |
| | EXOG | Exo/endonuclease G. (358 aa) |
| | APTX | Aprataxin. (341 aa) |
| | ENSCPOP00000029431 | Uncharacterized protein. (111 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (356 aa) |
| | RPP30 | Ribonuclease P/MRP subunit p30. (268 aa) |
| | TSNAX | Translin associated factor X. (290 aa) |
| | Fip1l1 | Fip1 domain-containing protein. (555 aa) |
| | ENSCPOP00000030166 | RNase_Zc3h12a domain-containing protein. (52 aa) |
| | RAD2 | Ribonuclease A D2; Belongs to the pancreatic ribonuclease family. (187 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase 3. (772 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (298 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (751 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa) |
| | EXOSC10 | Exosome component 10. (901 aa) |
| | Rnase6 | Ribonuclease A D1; Belongs to the pancreatic ribonuclease family. (151 aa) |
| | LOC100717485 | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (148 aa) |
| | ISG20L2 | Interferon stimulated exonuclease gene 20 like 2. (361 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | AGO2 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (857 aa) |
| | LOC100718706 | Nudix hydrolase domain-containing protein. (194 aa) |
| | LOC100716663 | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (147 aa) |
| | CPSF6 | Cleavage and polyadenylation specific factor 6. (588 aa) |
| | LAS1L | LAS1 like, ribosome biogenesis factor. (698 aa) |
| | Tut1 | RRM domain-containing protein. (852 aa) |
| | USB1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family. (266 aa) |
| | RNASE12 | Ribonuclease A family member 12 (inactive); Belongs to the pancreatic ribonuclease family. (144 aa) |
| | NOP9 | NOP9 nucleolar protein. (643 aa) |
| | NYNRIN | NYN domain and retroviral integrase containing. (1949 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | ZC3H12D | Zinc finger CCCH-type containing 12D. (464 aa) |
| | TSR1 | TSR1 ribosome maturation factor. (752 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1420 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1204 aa) |
| | DROSHA | Drosha ribonuclease III. (1295 aa) |
| | DXO | Decapping exoribonuclease. (397 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa) |
| | RCL1 | RNA terminal phosphate cyclase like 1. (373 aa) |
| | EDC3 | Enhancer of mRNA decapping 3. (508 aa) |
| | Tatdn2 | Uncharacterized protein. (624 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | H0VUW4_CAVPO | Uncharacterized protein; Belongs to the argonaute family. (746 aa) |
| | RPP38 | Ribonuclease P/MRP subunit p38. (284 aa) |
| | H0VVN7_CAVPO | RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (151 aa) |
| | N4BP2 | NEDD4 binding protein 2. (1675 aa) |
| | LOC100720895 | Ribonuclease A C1; Belongs to the pancreatic ribonuclease family. (152 aa) |
| | TREX2 | Three prime repair exonuclease 2. (236 aa) |
| | CSTF2 | Cleavage stimulation factor subunit 2. (597 aa) |
| | ANKRD31 | Ankyrin repeat domain 31. (1672 aa) |
| | RRP36 | Ribosomal RNA processing 36. (224 aa) |
| | C12orf10 | Chromosome 12 open reading frame 10. (377 aa) |
| | AEN | Apoptosis enhancing nuclease. (320 aa) |
| | PNLDC1 | PARN like, ribonuclease domain containing 1. (518 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain containing 1. (268 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (309 aa) |
| | H0W0H8_CAVPO | Uncharacterized protein. (336 aa) |
| | Rnaseh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (294 aa) |
| | LOC100718426 | Uncharacterized protein. (152 aa) |
| | N4BP1 | NEDD4 binding protein 1. (886 aa) |
| | NOL9 | Nucleolar protein 9. (724 aa) |
| | TRIR | Telomerase RNA component interacting RNase. (175 aa) |
| | NOB1 | RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (409 aa) |
| | KHNYN | KH and NYN domain containing. (657 aa) |
| | H0W827_CAVPO | Uncharacterized protein. (103 aa) |
| | MRPL44 | Mitochondrial ribosomal protein L44. (332 aa) |
| | RRS1 | Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (357 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | LOC100717209 | Ribonuclease pancreatic B; Belongs to the pancreatic ribonuclease family. (154 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (578 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa) |
| | H0WBK1_CAVPO | Uncharacterized protein. (163 aa) |
| | LOC100736130 | Uncharacterized protein. (287 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | LOC100712949 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (203 aa) |
| | PTBP1 | Polypyrimidine tract binding protein 1. (557 aa) |
| | ZC3H12C | Zinc finger CCCH-type containing 12C. (886 aa) |
| | PARN | Poly(A)-specific ribonuclease. (637 aa) |
| | ENSCPOP00000022359 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (167 aa) |
| | ERI1 | Exoribonuclease 1. (343 aa) |
| | TATDN1 | TatD DNase domain containing 1. (297 aa) |
| | ISG20 | Interferon stimulated exonuclease gene 20. (190 aa) |
| | AGO3 | Argonaute RISC catalytic component 3; Belongs to the argonaute family. (827 aa) |
| | Bivm | Uncharacterized protein. (503 aa) |
| | UTP23 | UTP23 small subunit processome component. (270 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | DCP1A | Decapping mRNA 1A. (601 aa) |
| | DIS3L | DIS3 like exosome 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (1055 aa) |
| | DFFB | DNA fragmentation factor subunit beta. (302 aa) |
| | EXO1 | Exonuclease 1. (839 aa) |
| | BMS1 | BMS1 ribosome biogenesis factor. (1277 aa) |
| | ERN1 | Endoplasmic reticulum to nucleus signaling 1. (974 aa) |
| | DNASE2 | Deoxyribonuclease 2, lysosomal. (357 aa) |
| | PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa) |
| | FCF1 | PINc domain-containing protein. (198 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1059 aa) |
| | REXO4 | REX4 homolog, 3'-5' exonuclease. (437 aa) |
| | FANCM | FA complementation group M. (1971 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (263 aa) |
| | PDE12 | Phosphodiesterase 12. (608 aa) |
| | DCP2 | Decapping mRNA 2. (422 aa) |
| | RPS21 | 40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (86 aa) |
| | PLD4 | Phospholipase D family member 4. (501 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa) |
| | ENDOD1 | Endonuclease domain containing 1. (457 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1275 aa) |
| | ZNRD1 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (100 aa) |
| | YBEY | YbeY metalloendoribonuclease. (164 aa) |
| | TATDN3 | TatD DNase domain containing 3. (229 aa) |
| | NUDT12 | Nudix hydrolase 12. (462 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (688 aa) |
| | POP1 | POP1 homolog, ribonuclease P/MRP subunit. (1012 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa) |
| | POP4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (220 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa) |
| | LRRC27 | Leucine rich repeat containing 27. (508 aa) |
| | N4BP2L1 | NEDD4 binding protein 2 like 1. (236 aa) |
| | SLFNL1 | Schlafen like 1. (371 aa) |
| | Xrn1 | 5'-3' exoribonuclease 1. (1386 aa) |
| | CNOT8 | CCR4-NOT transcription complex subunit 8. (292 aa) |
| | APLF | Aprataxin and PNKP like factor. (498 aa) |
| | NOCT | Nocturnin. (432 aa) |
| | ANGEL2 | Angel homolog 2. (544 aa) |
| | RNASEK | Ribonuclease K. (98 aa) |
| | PCF11 | PCF11 cleavage and polyadenylation factor subunit. (1553 aa) |
| | CSTF2T | Cleavage stimulation factor subunit 2 tau variant. (623 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa) |
| | RPP14 | Ribonuclease P/MRP subunit p14. (124 aa) |
| | EXOSC8 | Exosome component 8. (276 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | RAD51C | RAD51 paralog C. (373 aa) |
| | CNOT2 | CCR4-NOT transcription complex subunit 2. (544 aa) |
| | H0V3Y8_CAVPO | PRORP domain-containing protein. (566 aa) |
| | PIWIL1 | Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (835 aa) |
| | EXOSC7 | Exosome component 7. (291 aa) |
| | INTS11 | Integrator complex subunit 11. (611 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (877 aa) |
| | DCP1B | Decapping mRNA 1B. (592 aa) |
| | NME1 | Nucleoside diphosphate kinase. (152 aa) |
| | BOP1 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (734 aa) |
| | ENDOV | Endonuclease V. (260 aa) |
| | DNASE1L1 | Deoxyribonuclease; Belongs to the DNase I family. (307 aa) |
| | ASTE1 | Asteroid homolog 1. (685 aa) |
| | POP7 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family. (140 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (902 aa) |
| | TBL3 | Transducin beta like 3. (800 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (468 aa) |
| | RPP21 | Ribonuclease P/MRP subunit p21. (161 aa) |
| | DBR1 | Debranching RNA lariats 1. (544 aa) |
| | HORMAD1 | HORMA domain containing 1. (377 aa) |
| | SND1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (358 aa) |
| | HELZ2 | Helicase with zinc finger 2. (2942 aa) |
| | Ankle1 | Uncharacterized protein. (520 aa) |
| | H0V9B4_CAVPO | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (230 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1206 aa) |
| | LACTB2 | Lactamase beta 2. (288 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | Rnaset2 | Uncharacterized protein; Belongs to the RNase T2 family. (253 aa) |
| | Tsen2 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (448 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (562 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | MARF1 | Meiosis regulator and mRNA stability factor 1. (1738 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (303 aa) |
| | REXO5 | RNA exonuclease 5. (814 aa) |
| | ELAC2 | ElaC ribonuclease Z 2. (833 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (794 aa) |
| | XRN2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa) |
| | PLD3 | Phospholipase D family member 3. (490 aa) |
| | LOC100721277 | Uncharacterized protein. (681 aa) |
| | CPSF7 | Cleavage and polyadenylation specific factor 7. (471 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | KRI1 | KRI1 homolog. (693 aa) |
| | CNOT6L | CCR4-NOT transcription complex subunit 6 like. (462 aa) |
| | H0VGS2_CAVPO | Uncharacterized protein. (611 aa) |
| | REXO2 | RNA exonuclease 2. (237 aa) |
| | CPSF2 | Cleavage and polyadenylation specificity factor subunit 2. (782 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (783 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (550 aa) |
| | CPSF3 | Cleavage and polyadenylation specific factor 3. (684 aa) |
| | ANGEL1 | Angel homolog 1. (667 aa) |
| | DNASE2B | Deoxyribonuclease 2 beta. (361 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (848 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (396 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1831 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (607 aa) |
| | POP5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (168 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1. (764 aa) |
| | REXO1 | RNA exonuclease 1 homolog. (1231 aa) |
| | TSEN34 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (311 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2294 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (987 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (580 aa) |
| | ERI3 | ERI1 exoribonuclease family member 3. (337 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (913 aa) |
| | SWT1 | SWT1 RNA endoribonuclease homolog. (830 aa) |
