STRINGSTRING
TONSL TONSL XRCC4 XRCC4 VCP VCP ACTR3 ACTR3 RPA1 RPA1 SMC5 SMC5 RFWD3 RFWD3 POLK POLK SLF2 SLF2 IFFO1 IFFO1 SHLD2 SHLD2 SMCHD1 SMCHD1 ARPC1A ARPC1A H0UX17_CAVPO H0UX17_CAVPO KAT7 KAT7 SIRT7 SIRT7 WDR76 WDR76 Rad50 Rad50 UBQLN4 UBQLN4 WRAP53 WRAP53 RNF138 RNF138 TRAIP TRAIP APLF APLF SLF1 SLF1 PNKP PNKP POLL POLL KDM4D KDM4D XPC XPC UFL1 UFL1 RBBP8 RBBP8 SAMHD1 SAMHD1 ELOA ELOA PHF1 PHF1 RPA2 RPA2 HELQ HELQ INTS3 INTS3 EXD2 EXD2 Cgas Cgas SMARCAD1 SMARCAD1 SMARCAL1 SMARCAL1 CNTD1 CNTD1 DDB2 DDB2 Rec114 Rec114 HELB HELB NBN NBN PARP3 PARP3 RAD18 RAD18 RAD51 RAD51 OARD1 OARD1 MRE11 MRE11 SMC6 SMC6 NABP2 NABP2 WDR70 WDR70 Parp1 Parp1 RNF169 RNF169 Parp9 Parp9 Hrob Hrob LMNA LMNA H0VYM4_CAVPO H0VYM4_CAVPO H0VYV4_CAVPO H0VYV4_CAVPO WAS WAS PAXX PAXX PARP2 PARP2 CYREN CYREN NHEJ1 NHEJ1 ESCO2 ESCO2 HUS1 HUS1 AUNIP AUNIP PRPF19 PRPF19 LOC100736130 LOC100736130 ACTR2 ACTR2 NKX3-1 NKX3-1 RIF1 RIF1 MMS22L MMS22L CBX5 CBX5 TIMELESS TIMELESS ENSCPOP00000024428 ENSCPOP00000024428 ARPC5 ARPC5 ENSCPOP00000024830 ENSCPOP00000024830 XRCC5 XRCC5 RNF168 RNF168 ENSCPOP00000025800 ENSCPOP00000025800 CUL5 CUL5 RPA3 RPA3 DDB1 DDB1 POLH POLH LOC100728516 LOC100728516 INIP INIP SHLD1 SHLD1 CBX1 CBX1 TP53 TP53 ARPC2 ARPC2 ATF2 ATF2 ADPRHL2 ADPRHL2 RNF8 RNF8 ERCC6 ERCC6 NABP1 NABP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TONSLTonsoku like, DNA repair protein. (1395 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (411 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
SMC5Structural maintenance of chromosomes 5. (1102 aa)
RFWD3Ring finger and WD repeat domain 3. (764 aa)
POLKDNA polymerase kappa. (540 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1141 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (548 aa)
SHLD2Shieldin complex subunit 2. (905 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
H0UX17_CAVPOBRCT domain-containing protein. (722 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (612 aa)
SIRT7Sirtuin 7. (401 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (623 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
UBQLN4Ubiquilin 4. (593 aa)
WRAP53WD repeat containing antisense to TP53. (541 aa)
RNF138Ring finger protein 138. (245 aa)
TRAIPTRAF interacting protein. (469 aa)
APLFAprataxin and PNKP like factor. (498 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1061 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (523 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
KDM4DLysine demethylase 4D. (512 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (923 aa)
UFL1UFM1 specific ligase 1. (762 aa)
RBBP8RB binding protein 8, endonuclease. (900 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa)
ELOAElongin A. (757 aa)
PHF1PHD finger protein 1. (559 aa)
RPA2Replication protein A2. (270 aa)
HELQHelicase, POLQ like. (1054 aa)
INTS3Integrator complex subunit 3. (1007 aa)
EXD2Exonuclease 3'-5' domain containing 2. (619 aa)
CgasMab-21 domain-containing protein. (387 aa)
SMARCAD1Uncharacterized protein. (1032 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa)
CNTD1Cyclin N-terminal domain containing 1. (347 aa)
DDB2Damage specific DNA binding protein 2. (289 aa)
Rec114Uncharacterized protein. (82 aa)
HELBDNA helicase B. (1063 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
PARP3Poly [ADP-ribose] polymerase. (533 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (493 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
OARD1O-acyl-ADP-ribose deacylase 1. (152 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa)
SMC6Structural maintenance of chromosomes 6. (1091 aa)
NABP2Nucleic acid binding protein 2. (227 aa)
WDR70WD repeat domain 70. (650 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
RNF169Ring finger protein 169. (699 aa)
Parp9Uncharacterized protein. (703 aa)
HrobUncharacterized protein. (591 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (624 aa)
H0VYM4_CAVPOUncharacterized protein. (503 aa)
H0VYV4_CAVPOUncharacterized protein. (260 aa)
WASWASP actin nucleation promoting factor. (505 aa)
PAXXPAXX non-homologous end joining factor. (206 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
CYRENCell cycle regulator of NHEJ. (180 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (597 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
AUNIPAurora kinase A and ninein interacting protein. (351 aa)
PRPF19Pre-mRNA processing factor 19. (513 aa)
LOC100736130Uncharacterized protein. (287 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
NKX3-1NK3 homeobox 1. (224 aa)
RIF1Replication timing regulatory factor 1. (2387 aa)
MMS22LMMS22 like, DNA repair protein. (1237 aa)
CBX5Chromobox 5. (191 aa)
TIMELESSTimeless circadian regulator. (1239 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ENSCPOP00000024830Uncharacterized protein. (331 aa)
XRCC5X-ray repair cross complementing 5. (739 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
ENSCPOP00000025800Uncharacterized protein. (348 aa)
CUL5Cullin 5; Belongs to the cullin family. (820 aa)
RPA3Replication protein A3. (121 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
POLHDNA polymerase eta. (712 aa)
LOC100728516Uncharacterized protein. (346 aa)
INIPINTS3 and NABP interacting protein. (104 aa)
SHLD1Shieldin complex subunit 1. (216 aa)
CBX1Chromobox 1. (185 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (367 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
NABP1Nucleic acid binding protein 1. (204 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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