STRINGSTRING
SHISA9 SHISA9 B2M B2M ABHD6 ABHD6 EPS8 EPS8 OLFM3 OLFM3 CD40 CD40 ITGAM ITGAM ITGB7 ITGB7 ITGA6 ITGA6 TRAF2 TRAF2 ITGB4 ITGB4 TRBV19 TRBV19 GRIN1 GRIN1 TGFBR2 TGFBR2 CD6 CD6 ACVR2B ACVR2B TFRC TFRC PTPN6 PTPN6 GRIN2D GRIN2D HTRA2 HTRA2 CALCRL CALCRL DLG3 DLG3 CNIH2 CNIH2 TLR1 TLR1 PORCN PORCN CHRNA1 CHRNA1 Chrna7 Chrna7 CD247 CD247 NRN1 NRN1 RAMP2 RAMP2 TRAF3 TRAF3 PTK2B PTK2B BMP2 BMP2 CHRNA2 CHRNA2 Chrnb2 Chrnb2 ITGB1 ITGB1 CHUK CHUK CD79B CD79B IFNLR1 IFNLR1 GRIK4 GRIK4 ITGAV ITGAV TLR10 TLR10 CACNG7 CACNG7 OSMR OSMR TGFBR1 TGFBR1 ERBB3 ERBB3 CHRNB1 CHRNB1 JAK2 JAK2 ITGA9 ITGA9 IL18RAP IL18RAP ITGA1 ITGA1 SDCBP SDCBP IL27RA IL27RA GRIN2A GRIN2A VWC2L VWC2L RAMP3 RAMP3 IL6ST IL6ST CD3D CD3D LOC100730761 LOC100730761 STXBP5 STXBP5 INSR INSR ITGA11 ITGA11 CHRNA3 CHRNA3 CHRNA5 CHRNA5 STOML2 STOML2 LRRTM4 LRRTM4 CD79A CD79A GRIN3B GRIN3B CHRNB3 CHRNB3 LYN LYN GRID2 GRID2 Itgb3 Itgb3 TFR2 TFR2 HTR3A HTR3A HTR3B HTR3B HJV HJV CHRNA4 CHRNA4 IKBKB IKBKB SYK SYK BIRC2 BIRC2 ITGA8 ITGA8 CHRNA6 CHRNA6 ITGB5 ITGB5 H0VF00_CAVPO H0VF00_CAVPO ITGA4 ITGA4 ITGB8 ITGB8 ACVR1 ACVR1 EMILIN1 EMILIN1 ACVR2A ACVR2A SACM1L SACM1L CHRNA9 CHRNA9 ITGA5 ITGA5 ITGAL ITGAL ACVR1C ACVR1C ITGA7 ITGA7 ITGA2B ITGA2B GRIN3A GRIN3A GABBR2 GABBR2 GRIN2B GRIN2B CHRND CHRND IGF1R IGF1R TLR6 TLR6 ZAP70 ZAP70 TRAT1 TRAT1 TRAF6 TRAF6 ABHD12 ABHD12 APBB1IP APBB1IP GRIA1 GRIA1 ITGA3 ITGA3 GRIA3 GRIA3 VWC2 VWC2 Diablo Diablo SORBS1 SORBS1 ITGA10 ITGA10 CACNG2 CACNG2 GRIK2 GRIK2 ACVRL1 ACVRL1 CNTFR CNTFR CD3E CD3E GRIN2C GRIN2C ACVR1B ACVR1B GRIA4 GRIA4 GRIA2 GRIA2 GRIK1 GRIK1 CPT1C CPT1C LOC100735416 LOC100735416 ITGAE ITGAE ITGA2 ITGA2 ITGB2 ITGB2 AMHR2 AMHR2 CHRNG CHRNG CSF2 CSF2 GP1BB GP1BB TSPAN32 TSPAN32 GRIK3 GRIK3 OLFM1 OLFM1 Rnf31 Rnf31 CACNG4 CACNG4 IL18R1 IL18R1 GP9 GP9 OLFM2 OLFM2 CSF2RB CSF2RB H0W649_CAVPO H0W649_CAVPO CD3G CD3G ITGB6 ITGB6 H0W6Y0_CAVPO H0W6Y0_CAVPO GRIK5 GRIK5 CHRNE CHRNE CNIH3 CNIH3 GPR156 GPR156 TLR2 TLR2 SKAP1 SKAP1 RAMP1 RAMP1 CHRNA10 CHRNA10 Ceacam1 Ceacam1 CHRNB4 CHRNB4 DLG4 DLG4 IL12RB1 IL12RB1 IL6R IL6R SHISA8 SHISA8 TRAF5 TRAF5 ITGAD ITGAD GABBR1 GABBR1 CACNG3 CACNG3 PLP1 PLP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHISA9Shisa family member 9. (424 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa)
ABHD6Abhydrolase domain containing 6. (337 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (821 aa)
OLFM3Olfactomedin 3. (478 aa)
CD40CD40 molecule. (285 aa)
ITGAMIntegrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated act [...] (1123 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (809 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1158 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
ITGB4Integrin beta. (1815 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CD6CD6 molecule. (670 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
TFRCTransferrin receptor protein 1. (765 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
HTRA2HtrA serine peptidase 2. (455 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (464 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (850 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (818 aa)
PORCNPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (461 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (457 aa)
Chrna7Uncharacterized protein. (483 aa)
CD247CD247 molecule. (164 aa)
NRN1Neuritin 1. (142 aa)
RAMP2Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (157 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (519 aa)
Chrnb2Uncharacterized protein. (499 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
CD79BCD79b molecule. (285 aa)
IFNLR1Interferon lambda receptor 1. (534 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (963 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (777 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
OSMROncostatin M receptor. (958 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (502 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1008 aa)
IL18RAPInterleukin 18 receptor accessory protein. (564 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1168 aa)
SDCBPSyndecan binding protein. (294 aa)
IL27RAInterleukin 27 receptor subunit alpha. (641 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
VWC2LVon Willebrand factor C domain containing 2 like. (222 aa)
RAMP3Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (192 aa)
IL6STInterleukin 6 signal transducer. (903 aa)
CD3DCD3d molecule. (171 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
STXBP5Syntaxin binding protein 5. (1067 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1188 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (506 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
STOML2Stomatin like 2. (356 aa)
LRRTM4Leucine rich repeat transmembrane neuronal 4. (591 aa)
CD79ACD79a molecule. (224 aa)
GRIN3BGlutamate ionotropic receptor NMDA type subunit 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (845 aa)
CHRNB3Cholinergic receptor nicotinic beta 3 subunit. (463 aa)
LYNTyrosine-protein kinase. (512 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
TFR2Transferrin receptor 2. (788 aa)
HTR3A5-hydroxytryptamine receptor 3A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand- gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. (456 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (442 aa)
HJVHemojuvelin BMP co-receptor. (426 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
SYKTyrosine-protein kinase. (579 aa)
BIRC2Baculoviral IAP repeat containing 2. (615 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (801 aa)
H0VF00_CAVPOUncharacterized protein. (323 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
EMILIN1Elastin microfibril interfacer 1. (1017 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
SACM1LSAC1 like phosphatidylinositide phosphatase. (587 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (465 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1102 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1170 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (479 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1137 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1007 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (820 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (517 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
ZAP70Tyrosine-protein kinase. (551 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (187 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
ABHD12Abhydrolase domain containing 12. (397 aa)
APBB1IPAmyloid beta precursor protein binding family B member 1 interacting protein. (611 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1048 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
VWC2Von Willebrand factor C domain containing 2. (315 aa)
DiabloUncharacterized protein. (239 aa)
SORBS1Sorbin and SH3 domain containing 1. (933 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1164 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
CNTFRCiliary neurotrophic factor receptor. (371 aa)
CD3ECD3e molecule. (194 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (807 aa)
LOC100735416VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1159 aa)
ITGAEIntegrin subunit alpha E; Belongs to the integrin alpha chain family. (1164 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
ITGB2Integrin beta. (767 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (565 aa)
CHRNGCholinergic receptor nicotinic gamma subunit. (515 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (145 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (212 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (265 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (884 aa)
OLFM1Olfactomedin 1. (483 aa)
Rnf31Uncharacterized protein. (1072 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
IL18R1Interleukin 18 receptor 1. (481 aa)
GP9Glycoprotein IX platelet. (181 aa)
OLFM2Olfactomedin 2. (457 aa)
CSF2RBFibronectin type-III domain-containing protein. (839 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
CD3GCD3g molecule. (181 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (788 aa)
H0W6Y0_CAVPOUncharacterized protein. (242 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (892 aa)
CHRNECholinergic receptor nicotinic epsilon subunit. (493 aa)
CNIH3Cornichon family AMPA receptor auxiliary protein 3. (129 aa)
GPR156G protein-coupled receptor 156. (788 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
SKAP1Src kinase associated phosphoprotein 1. (365 aa)
RAMP1Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL (By similarity). (148 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
Ceacam1Uncharacterized protein. (518 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (489 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (754 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (714 aa)
IL6RInterleukin 6 receptor. (450 aa)
SHISA8Shisa family member 8. (301 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
ITGADIntegrin subunit alpha D; Belongs to the integrin alpha chain family. (1175 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
PLP1Proteolipid protein 1. (277 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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