STRINGSTRING
Foxp1 Foxp1 FGF13 FGF13 SCN5A SCN5A JUP JUP Kcnj2 Kcnj2 CAV3 CAV3 Chrnb2 Chrnb2 Camk2d Camk2d ENSCPOP00000029646 ENSCPOP00000029646 KCNB1 KCNB1 FGF12 FGF12 SLC9A1 SLC9A1 SUMO1 SUMO1 RYR2 RYR2 CAV1 CAV1 FLNA FLNA ANK2 ANK2 GPR35 GPR35 CD36 CD36 PAWR PAWR KCNAB2 KCNAB2 GBA GBA CACNB3 CACNB3 CNR2 CNR2 TMEM161B TMEM161B FMR1 FMR1 AKAP9 AKAP9 DSC2 DSC2 DSP DSP SLC8A2 SLC8A2 CXADR CXADR RAPGEF4 RAPGEF4 MTNR1B MTNR1B TMEM130 TMEM130 Trpa1 Trpa1 Trpc4 Trpc4 PKP2 PKP2 CHRNA5 CHRNA5 MECP2 MECP2 KCNC4 KCNC4 SCN9A SCN9A LOC100730761 LOC100730761 CTNNA3 CTNNA3 HCN1 HCN1 KCNIP1 KCNIP1 RANGRF RANGRF Hnrnpa1 Hnrnpa1 NPS NPS DSG2 DSG2 LOC100732533 LOC100732533 BIN1 BIN1 CNR1 CNR1 TRPM4 TRPM4 HCN4 HCN4 GJA5 GJA5 CACNA2D1 CACNA2D1 TBX18 TBX18 KCNE3 KCNE3 CACNA1C CACNA1C ATP2A2 ATP2A2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Foxp1Fork-head domain-containing protein. (687 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
JUPJunction plakoglobin. (745 aa)
Kcnj2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
Chrnb2Uncharacterized protein. (499 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
ENSCPOP00000029646RRM domain-containing protein. (236 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
RYR2Ryanodine receptor 2. (4910 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
FLNAFilamin A. (2645 aa)
ANK2Ankyrin 2. (3876 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (327 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
PAWRPro-apoptotic WT1 regulator. (307 aa)
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (382 aa)
GBAGlucosylceramidase. (516 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (355 aa)
TMEM161BTransmembrane protein 161B. (489 aa)
FMR1Fragile X mental retardation 1. (612 aa)
AKAP9A-kinase anchoring protein 9. (3887 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (900 aa)
DSPDesmoplakin. (2805 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
CXADRUncharacterized protein. (356 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TMEM130Transmembrane protein 130. (345 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
Trpc4Transient receptor potential channel 4 alpha; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
PKP2Plakophilin 2. (835 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (594 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1986 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
CTNNA3Catenin alpha 3. (895 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (671 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (227 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
Hnrnpa1RRM domain-containing protein. (324 aa)
NPSNeuropeptide S. (72 aa)
DSG2Desmoglein 2. (985 aa)
LOC100732533Uncharacterized protein. (311 aa)
BIN1Bridging integrator 1. (577 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1186 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
TBX18T-box transcription factor 18. (606 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (105 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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