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H0V4J9_CAVPO H0V4J9_CAVPO GRIN2B GRIN2B GRIK5 GRIK5 CHRM1 CHRM1 SLC6A5 SLC6A5 KCNC3 KCNC3 EFNB3 EFNB3 LRFN3 LRFN3 ATP2B2 ATP2B2 SLC6A1 SLC6A1 Chrm3 Chrm3 GRM7 GRM7 P2RX3 P2RX3 KCNA3 KCNA3 ADGRL1 ADGRL1 SCN8A SCN8A NCSTN NCSTN CACNA1E CACNA1E CHRM2 CHRM2 SCN10A SCN10A GRM3 GRM3 GLRA1 GLRA1 GRIN2A GRIN2A LOC100730761 LOC100730761 PTPRS PTPRS KCNC4 KCNC4 CACNA1H CACNA1H KCNC1 KCNC1 ERBB4 ERBB4 EPHA4 EPHA4 EPHB2 EPHB2 SLC1A7 SLC1A7 Atp1a3 Atp1a3 CHRNA4 CHRNA4 CHRNA6 CHRNA6 DRD2 DRD2 SLC6A11 SLC6A11 SLC1A2 SLC1A2 ADCY8 ADCY8 Cntnap4 Cntnap4 APH1A APH1A GABBR2 GABBR2 GABRA5 GABRA5 KCNA1 KCNA1 NCAM1 NCAM1 CDH10 CDH10 GRIK1 GRIK1 GRIA2 GRIA2 NECTIN1 NECTIN1 PRRT2 PRRT2 PSEN2 PSEN2 SLC1A6 SLC1A6 SCN1A SCN1A SCN2A SCN2A CDH9 CDH9 SYT11 SYT11 KCNH1 KCNH1 CANX CANX STX1A STX1A GRIA3 GRIA3 PTPRD PTPRD Kcnj3 Kcnj3 EFNB2 EFNB2 GRIK4 GRIK4 SLC6A9 SLC6A9 SYT7 SYT7 LPAR2 LPAR2 HTR1A HTR1A ENSCPOP00000030659 ENSCPOP00000030659 Chrnb2 Chrnb2 ATP2B3 ATP2B3 CADM1 CADM1 P2RX1 P2RX1 Chrna7 Chrna7 EFNB1 EFNB1 OPRD1 OPRD1 PSENEN PSENEN KCNA2 KCNA2 GPM6A GPM6A ENSCPOP00000027864 ENSCPOP00000027864 ENSCPOP00000027747 ENSCPOP00000027747 KCNA4 KCNA4 KCNMA1 KCNMA1 CDH2 CDH2 P2RY2 P2RY2 GRIN1 GRIN1 SLC6A7 SLC6A7 DRD1 DRD1 PSEN1 PSEN1 ADAM23 ADAM23 ATP2B4 ATP2B4 GRIA1 GRIA1 CACNA1C CACNA1C FXYD6 FXYD6 ATP2B1 ATP2B1 CADM3 CADM3 NPTN NPTN SCN11A SCN11A GABBR1 GABBR1 Drd4 Drd4 SLC6A3 SLC6A3 KCNJ9 KCNJ9 HTR1B HTR1B CNR1 CNR1 H0WA79_CAVPO H0WA79_CAVPO CACNA1A CACNA1A CHRM4 CHRM4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0V4J9_CAVPOUncharacterized protein. (291 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (892 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
SLC6A5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (764 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (729 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
LRFN3Leucine rich repeat and fibronectin type III domain containing 3. (626 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (589 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (528 aa)
ADGRL1Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family. (1491 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1876 aa)
NCSTNNicastrin. (709 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
GRM3Glutamate metabotropic receptor 3. (877 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1805 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (594 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2337 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
ERBB4Receptor protein-tyrosine kinase. (1263 aa)
EPHA4EPH receptor A4. (986 aa)
EPHB2EPH receptor B2. (949 aa)
SLC1A7Amino acid transporter. (574 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
SLC6A11Solute carrier family 6 member 11. (640 aa)
SLC1A2Amino acid transporter. (573 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
Cntnap4Uncharacterized protein. (1298 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (820 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
NCAM1Neural cell adhesion molecule 1. (848 aa)
CDH10Cadherin 10; Cadherins are calcium-dependent cell adhesion proteins. (705 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
NECTIN1Nectin cell adhesion molecule 1. (374 aa)
PRRT2Proline rich transmembrane protein 2. (340 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
SLC1A6Amino acid transporter. (560 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
CDH9Cadherin 9; Cadherins are calcium-dependent cell adhesion proteins. (789 aa)
SYT11Synaptotagmin 11. (431 aa)
KCNH1Uncharacterized protein. (989 aa)
CANXCalnexin. (593 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1767 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (295 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (633 aa)
SYT7Synaptotagmin 7. (556 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (348 aa)
HTR1A5-hydroxytryptamine receptor 1A. (421 aa)
ENSCPOP00000030659G_PROTEIN_RECEP_F3_4 domain-containing protein. (497 aa)
Chrnb2Uncharacterized protein. (499 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1226 aa)
CADM1Cell adhesion molecule 1. (475 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
Chrna7Uncharacterized protein. (483 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (345 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
GPM6AGlycoprotein M6A. (278 aa)
ENSCPOP00000027864Uncharacterized protein. (121 aa)
ENSCPOP00000027747LAM_G_DOMAIN domain-containing protein. (151 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (622 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
P2RY2Purinergic receptor P2Y2; Belongs to the G-protein coupled receptor 1 family. (376 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
SLC6A7Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (637 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ADAM23ADAM metallopeptidase domain 23. (775 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
FXYD6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (95 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
CADM3Cell adhesion molecule 3. (429 aa)
NPTNNeuroplastin. (397 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1719 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
Drd4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
HTR1B5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (389 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
H0WA79_CAVPOANF_receptor domain-containing protein. (187 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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