STRINGSTRING
HTR3B HTR3B Scnn1g Scnn1g GRIK1 GRIK1 GRIA2 GRIA2 ASIC1 ASIC1 KCNN2 KCNN2 GRIA4 GRIA4 KCNK1 KCNK1 GRIN2C GRIN2C CCDC51 CCDC51 KCNH6 KCNH6 GRIK2 GRIK2 PEX5L PEX5L TPCN2 TPCN2 GRIA3 GRIA3 GRIA1 GRIA1 CFAP299 CFAP299 P2rx4 P2rx4 H0V4J9_CAVPO H0V4J9_CAVPO TPCN1 TPCN1 Trpm8 Trpm8 CHRND CHRND GRIN2B GRIN2B GRIN3A GRIN3A MCOLN2 MCOLN2 RASA3 RASA3 CHRNA9 CHRNA9 ASIC5 ASIC5 CHRNA6 CHRNA6 MCOLN1 MCOLN1 TRPV1 TRPV1 TRPM5 TRPM5 KCNJ6 KCNJ6 CHRNA4 CHRNA4 HTR3A HTR3A Aqp1 Aqp1 Trpa1 Trpa1 KCNJ8 KCNJ8 CNGA2 CNGA2 Scnn1d Scnn1d CHRNB3 CHRNB3 ITPR2 ITPR2 CHRNA5 CHRNA5 CHRNA3 CHRNA3 P2RX6 P2RX6 CNGB3 CNGB3 LOC100730761 LOC100730761 Scnn1b Scnn1b GRIN2A GRIN2A P2RX2 P2RX2 Kcnj13 Kcnj13 HCN1 HCN1 H0VQQ2_CAVPO H0VQQ2_CAVPO PKD2 PKD2 CHRNB1 CHRNB1 P2rx5 P2rx5 RYR1 RYR1 KCNN3 KCNN3 TRPM2 TRPM2 Kcnj12 Kcnj12 P2RX3 P2RX3 CHRNG CHRNG KCNJ14 KCNJ14 KCNJ4 KCNJ4 KCNH2 KCNH2 GRIK3 GRIK3 CNGA1 CNGA1 SCNN1A SCNN1A CNGA3 CNGA3 CNGA4 CNGA4 P2rx7 P2rx7 KCNJ1 KCNJ1 KCNN1 KCNN1 GRIK5 GRIK5 CHRNE CHRNE ITPR3 ITPR3 KCNJ11 KCNJ11 CHRNA10 CHRNA10 TRPM4 TRPM4 CHRNB4 CHRNB4 KCNJ9 KCNJ9 HCN4 HCN4 KCNH7 KCNH7 ASIC2 ASIC2 HCN2 HCN2 KCNJ15 KCNJ15 KCNE2 KCNE2 TMEM177 TMEM177 ASIC4 ASIC4 ASIC3 ASIC3 MCOLN3 MCOLN3 LOC100714922 LOC100714922 ENSCPOP00000026472 ENSCPOP00000026472 KCNJ10 KCNJ10 GRIN1 GRIN1 KCNJ5 KCNJ5 GRIN2D GRIN2D RYR2 RYR2 RYR3 RYR3 CHRNA1 CHRNA1 Chrna7 Chrna7 P2RX1 P2RX1 KCNJ16 KCNJ16 ITPR1 ITPR1 CHRNA2 CHRNA2 Chrnb2 Chrnb2 Kcnj2 Kcnj2 GRIK4 GRIK4 Kcnj3 Kcnj3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (442 aa)
Scnn1gUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (653 aa)
GRIK1Glutamate ionotropic receptor kainate type subunit 1. (934 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
KCNK1Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium [...] (336 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1209 aa)
CCDC51Coiled-coil domain containing 51. (408 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (916 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
PEX5LPeroxisomal biogenesis factor 5 like. (650 aa)
TPCN2Two pore channel 2. (752 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
CFAP299Cilia and flagella associated protein 299. (233 aa)
P2rx4Uncharacterized protein. (343 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
TPCN1Two pore channel 1. (817 aa)
Trpm8Transient potential cation channel subfamily M member 8. (1104 aa)
CHRNDCholinergic receptor nicotinic delta subunit. (517 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1114 aa)
MCOLN2Mucolipin 2. (540 aa)
RASA3RAS p21 protein activator 3. (833 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (465 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
MCOLN1Mucolipin 1. (582 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
TRPM5Transient receptor potential cation channel subfamily M member 5. (1159 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (429 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (620 aa)
HTR3A5-hydroxytryptamine receptor 3A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand- gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. (456 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
KCNJ8Uncharacterized protein. (468 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (663 aa)
Scnn1dUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (618 aa)
CHRNB3Cholinergic receptor nicotinic beta 3 subunit. (463 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (506 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (381 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (667 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
Scnn1bUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
P2RX2P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity); Belongs to the P2X receptor family. (411 aa)
Kcnj13Inward rectifier potassium channel 13; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependen [...] (352 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (671 aa)
H0VQQ2_CAVPOCyclic nucleotide-binding domain-containing protein. (852 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (502 aa)
P2rx5P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (456 aa)
RYR1Ryanodine receptor 1. (4554 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (720 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1502 aa)
Kcnj12Uncharacterized protein. (535 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
CHRNGCholinergic receptor nicotinic gamma subunit. (515 aa)
KCNJ14Inwardly-rectifying potassium channel Kir2.4. (439 aa)
KCNJ4Uncharacterized protein. (443 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1144 aa)
GRIK3Glutamate ionotropic receptor kainate type subunit 3. (884 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (507 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Belongs to the amilori [...] (680 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (647 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (574 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (376 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (558 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (892 aa)
CHRNECholinergic receptor nicotinic epsilon subunit. (493 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] (390 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (489 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1186 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1173 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (783 aa)
KCNJ15ATP-sensitive inward rectifier potassium channel 15; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). (421 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa)
TMEM177Transmembrane protein 177. (311 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (539 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
MCOLN3Mucolipin 3. (553 aa)
LOC100714922Ion_trans domain-containing protein. (685 aa)
ENSCPOP00000026472Uncharacterized protein. (286 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (808 aa)
RYR2Ryanodine receptor 2. (4910 aa)
RYR3Ryanodine receptor 3. (4843 aa)
CHRNA1Cholinergic receptor nicotinic alpha 1 subunit. (457 aa)
Chrna7Uncharacterized protein. (483 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
KCNJ16Inwardly-rectifying potassium channel Kir5.1. (419 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
CHRNA2Cholinergic receptor nicotinic alpha 2 subunit. (519 aa)
Chrnb2Uncharacterized protein. (499 aa)
Kcnj2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)
GRIK4Glutamate ionotropic receptor kainate type subunit 4. (956 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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