STRINGSTRING
EDN3 EDN3 CASQ2 CASQ2 Ywhae Ywhae LRRC55 LRRC55 KCNE4 KCNE4 PRNP PRNP FHL1 FHL1 DPP6 DPP6 ITGB1 ITGB1 Ank3 Ank3 CAV3 CAV3 ABCC9 ABCC9 AMIGO1 AMIGO1 Vamp2 Vamp2 WWP2 WWP2 AMIGO2 AMIGO2 FLNA FLNA WNK1 WNK1 DNM2 DNM2 AGRN AGRN RGS4 RGS4 PTGER3 PTGER3 ANK2 ANK2 RAPGEF3 RAPGEF3 ATP1B2 ATP1B2 NEDD4L NEDD4L RGS7 RGS7 LRRC38 LRRC38 KCNE1 KCNE1 KCNG1 KCNG1 KCNE3 KCNE3 KCNS1 KCNS1 AKAP7 AKAP7 KCNE2 KCNE2 WNK2 WNK2 KCNMB1 KCNMB1 WNK4 WNK4 KCNIP2 KCNIP2 Fxyd2 Fxyd2 BIN1 BIN1 KEL KEL KCNJ1 KCNJ1 PTEN PTEN GRP GRP KCNS2 KCNS2 KCNH2 KCNH2 GNB2 GNB2 NPPA NPPA KCNK3 KCNK3 KCNQ1 KCNQ1 LRRC52 LRRC52 KCNIP3 KCNIP3 KCNIP1 KCNIP1 ACTN2 ACTN2 STK39 STK39 KLHL24 KLHL24 NETO2 NETO2 KCNC1 KCNC1 MTNR1B MTNR1B NETO1 NETO1 CD63 CD63 OXSR1 OXSR1 H0VBD1_CAVPO H0VBD1_CAVPO CRBN CRBN AKAP6 AKAP6 WNK3 WNK3 DPP10 DPP10 KCNAB1 KCNAB1 AKAP9 AKAP9 KCNA1 KCNA1 GAL GAL TREM2 TREM2 KCNC2 KCNC2 KCNAB2 KCNAB2 KCNAB3 KCNAB3 ABCC8 ABCC8 NEDD4 NEDD4 KCNN2 KCNN2 AGER AGER KCNIP4 KCNIP4 CAV1 CAV1 SUMO1 SUMO1 ATP1B1 ATP1B1 ANO6 ANO6 SNX27 SNX27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDN3Endothelin 3. (200 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
LRRC55Leucine rich repeat containing 55. (328 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (174 aa)
PRNPMajor prion protein; Belongs to the prion family. (244 aa)
FHL1Four and a half LIM domains 1. (323 aa)
DPP6Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family. (864 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
Ank3Uncharacterized protein. (1948 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
ABCC9ATP binding cassette subfamily C member 9. (1546 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (492 aa)
Vamp2V-SNARE coiled-coil homology domain-containing protein. (164 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (521 aa)
FLNAFilamin A. (2645 aa)
WNK1WNK lysine deficient protein kinase 1. (2528 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (878 aa)
AGRNAgrin. (1967 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
ANK2Ankyrin 2. (3876 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (252 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
RGS7Regulator of G protein signaling 7. (477 aa)
LRRC38Leucine rich repeat containing 38. (295 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (125 aa)
KCNG1Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family. (515 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (105 aa)
KCNS1Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (497 aa)
AKAP7A-kinase anchoring protein 7. (336 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa)
WNK2WNK lysine deficient protein kinase 2. (2111 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
WNK4WNK lysine deficient protein kinase 4. (1229 aa)
KCNIP2Potassium voltage-gated channel interacting protein 2. (270 aa)
Fxyd2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
BIN1Bridging integrator 1. (577 aa)
KELKell metallo-endopeptidase (Kell blood group). (706 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (376 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (143 aa)
KCNS2Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. (445 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1144 aa)
GNB2G protein subunit beta 2. (378 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
KCNK3Potassium two pore domain channel subfamily K member 3. (270 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
LRRC52Leucine rich repeat containing 52. (316 aa)
KCNIP3Potassium voltage-gated channel interacting protein 3. (256 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (227 aa)
ACTN2Actinin alpha 2. (894 aa)
STK39Serine/threonine kinase 39. (474 aa)
KLHL24Kelch like family member 24. (600 aa)
NETO2Neuropilin and tolloid like 2. (520 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (366 aa)
NETO1Neuropilin and tolloid like 1. (450 aa)
CD63Tetraspanin. (238 aa)
OXSR1Oxidative stress responsive kinase 1. (526 aa)
H0VBD1_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa)
CRBNCereblon. (442 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
WNK3WNK lysine deficient protein kinase 3. (1746 aa)
DPP10Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (776 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
AKAP9A-kinase anchoring protein 9. (3887 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (418 aa)
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (382 aa)
KCNAB3Potassium voltage-gated channel subfamily A regulatory beta subunit 3. (404 aa)
ABCC8ATP binding cassette subfamily C member 8. (1549 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (143 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (306 aa)
ANO6Anoctamin. (922 aa)
SNX27Sorting nexin 27. (541 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.