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CLCN5 CLCN5 CLCA2 CLCA2 SLC26A8 SLC26A8 CLCN1 CLCN1 SLC26A3 SLC26A3 SLC12A2 SLC12A2 ANO5 ANO5 SLC6A1 SLC6A1 CLIC4 CLIC4 CLIC3 CLIC3 LOC100730738 LOC100730738 SLC12A5 SLC12A5 GABRB1 GABRB1 SLC6A3 SLC6A3 ANO10 ANO10 GABRE GABRE BSND BSND ANO4 ANO4 ENSCPOP00000030667 ENSCPOP00000030667 GLRB GLRB SLC26A10 SLC26A10 CLCN4 CLCN4 SLC26A6 SLC26A6 CLIC5 CLIC5 Ttyh3 Ttyh3 ANO6 ANO6 ANO1 ANO1 TTYH1 TTYH1 CLCN6 CLCN6 CLCN7 CLCN7 ENSCPOP00000025593 ENSCPOP00000025593 SLC4A8 SLC4A8 GLRA4 GLRA4 BEST4 BEST4 SLC4A1 SLC4A1 CLIC1 CLIC1 H0W682_CAVPO H0W682_CAVPO GABRA2 GABRA2 TTYH2 TTYH2 BEST3 BEST3 SLC26A4 SLC26A4 GABRD GABRD PCYOX1 PCYOX1 SLC26A7 SLC26A7 SLC18A2 SLC18A2 ANO9 ANO9 LRRC8A LRRC8A GABRA5 GABRA5 SLC12A1 SLC12A1 ANO3 ANO3 GABRB3 GABRB3 GABRG2 GABRG2 SLC26A2 SLC26A2 SLC18A1 SLC18A1 SLC12A9 SLC12A9 GABRA3 GABRA3 LOC100727546 LOC100727546 BEST1 BEST1 SLC12A7 SLC12A7 SLC17A7 SLC17A7 GABRA1 GABRA1 ANO8 ANO8 SLC1A3 SLC1A3 CLIC2 CLIC2 SLC12A6 SLC12A6 SLC26A5 SLC26A5 SLC12A3 SLC12A3 SLC1A4 SLC1A4 SLC17A8 SLC17A8 CLCN2 CLCN2 PACC1 PACC1 GABRA4 GABRA4 SLC26A9 SLC26A9 GLRA2 GLRA2 GABRA6 GABRA6 Nmur2 Nmur2 SLC22A3 SLC22A3 SLC6A4 SLC6A4 GABRR1 GABRR1 GABRR2 GABRR2 GABRP GABRP GABRQ GABRQ SLC12A4 SLC12A4 GLRA3 GLRA3 SLC12A8 SLC12A8 CFTR CFTR GABRR3 GABRR3 SLC1A1 SLC1A1 SLC17A6 SLC17A6 GLRA1 GLRA1 SLC26A1 SLC26A1 CLCC1 CLCC1 ANO2 ANO2 CLCN3 CLCN3 BEST2 BEST2 SLC6A2 SLC6A2 CLCA1 CLCA1 LOC100727821 LOC100727821 GABRB2 GABRB2 LOC100726159 LOC100726159 GABRG1 GABRG1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CLCN5H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity); Belongs to the chloride channel (TC 2.A.49) family. ClC- 5/CLCN5 subfamily. (787 aa)
CLCA2Chloride channel accessory 2. (861 aa)
SLC26A8Testis anion transporter 1. (948 aa)
CLCN1Chloride channel protein. (990 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (754 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
ANO5Anoctamin. (886 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (589 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
CLIC3Chloride intracellular channel 3. (237 aa)
LOC100730738Chloride channel protein. (729 aa)
SLC12A5Solute carrier family 12 member 5. (1138 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (419 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
ANO10Anoctamin. (661 aa)
GABREGamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (482 aa)
BSNDBarttin CLCNK type accessory beta subunit. (321 aa)
ANO4Anoctamin. (955 aa)
ENSCPOP00000030667Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (245 aa)
GLRBGlycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
SLC26A10Solute carrier family 26 member 10. (668 aa)
CLCN4Chloride channel protein. (747 aa)
SLC26A6STAS domain-containing protein. (725 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
Ttyh3Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (524 aa)
ANO6Anoctamin. (922 aa)
ANO1Anoctamin. (1011 aa)
TTYH1Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (380 aa)
CLCN6Chloride channel protein. (899 aa)
CLCN7Chloride channel protein. (804 aa)
ENSCPOP00000025593Uncharacterized protein. (180 aa)
SLC4A8Anion exchange protein. (1090 aa)
GLRA4Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
BEST4Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (461 aa)
SLC4A1Anion exchange protein. (901 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
H0W682_CAVPOProtein tweety homolog; Probable chloride channel. (108 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
TTYH2Protein tweety homolog; Probable chloride channel. (533 aa)
BEST3Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (673 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (739 aa)
GABRDGamma-aminobutyric acid type A receptor delta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
PCYOX1Prenylcysteine oxidase 1. (505 aa)
SLC26A7Anion exchange transporter. (656 aa)
SLC18A2Solute carrier family 18 member A2. (516 aa)
ANO9Anoctamin. (746 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
SLC12A1Solute carrier family 12 member 1. (1099 aa)
ANO3Anoctamin. (981 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
GABRG2Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (475 aa)
SLC26A2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (738 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
SLC12A9Solute carrier family 12 member 9. (915 aa)
GABRA3Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (505 aa)
LOC100727546VWFA domain-containing protein. (923 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (566 aa)
SLC12A7Solute carrier family 12 member 7. (1090 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
GABRA1Gamma-aminobutyric acid type A receptor alpha1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
ANO8Anoctamin. (1034 aa)
SLC1A3Amino acid transporter. (542 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (246 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa)
SLC12A3Solute carrier family 12 member 3. (1004 aa)
SLC1A4Solute carrier family 1 member 4. (532 aa)
SLC17A8Solute carrier family 17 member 8. (476 aa)
CLCN2Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity); Belongs [...] (889 aa)
PACC1Proton activated chloride channel 1. (350 aa)
GABRA4Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (576 aa)
SLC26A9Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (789 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
GABRA6Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (453 aa)
Nmur2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa)
SLC22A3Solute carrier family 22 member 3. (396 aa)
SLC6A4Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily. (612 aa)
GABRR1Gamma-aminobutyric acid type A receptor rho1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (480 aa)
GABRR2Gamma-aminobutyric acid type A receptor rho2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (478 aa)
GABRPGamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (440 aa)
GABRQGamma-aminobutyric acid type A receptor theta subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (617 aa)
SLC12A4Solute carrier family 12 member 4. (1085 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
SLC12A8Solute carrier family 12 member 8. (663 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1448 aa)
GABRR3Gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene); Belongs to the ligand-gated ion channel (TC 1.A.9) family. (467 aa)
SLC1A1Amino acid transporter. (525 aa)
SLC17A6Solute carrier family 17 member 6. (566 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
SLC26A1Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (702 aa)
CLCC1Chloride channel CLIC like 1. (529 aa)
ANO2Anoctamin. (1003 aa)
CLCN3H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity); Belongs to the chloride channel (TC 2.A.49) family. ClC- 3/CLCN3 subfamily. (865 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (505 aa)
SLC6A2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (626 aa)
CLCA1Chloride channel accessory 1. (913 aa)
LOC100727821VWFA domain-containing protein. (923 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
LOC100726159VWFA domain-containing protein. (911 aa)
GABRG1Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (384 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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