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ATP6V1B2 ATP6V1B2 ATP8 ATP8 COX2 COX2 COX1 COX1 SLC45A1 SLC45A1 SLC25A12 SLC25A12 SLC36A1 SLC36A1 ATP5PB ATP5PB SLC9A6 SLC9A6 SLC17A6 SLC17A6 ATP5F1A ATP5F1A SLC4A10 SLC4A10 ATP6V1A ATP6V1A SLC11A1 SLC11A1 ATP6V0A1 ATP6V0A1 LETM1 LETM1 B3GNTL1 B3GNTL1 ATP6V0D1 ATP6V0D1 SLC9A5 SLC9A5 SLC2A13 SLC2A13 UCP2 UCP2 Atp1a3 Atp1a3 ATP6V1B1 ATP6V1B1 SLC9B2 SLC9B2 COX4I2 COX4I2 ATP6V1C1 ATP6V1C1 COX15 COX15 SLC36A3 SLC36A3 ATP6V0D2 ATP6V0D2 SLC45A2 SLC45A2 SLC25A5 SLC25A5 SLC9C1 SLC9C1 ATP6V1D ATP6V1D Atp5mc1 Atp5mc1 ASIC5 ASIC5 SLC32A1 SLC32A1 SLC36A2 SLC36A2 SLC9A2 SLC9A2 ATP6V0B ATP6V0B TMCO3 TMCO3 SLC15A2 SLC15A2 SLC17A7 SLC17A7 SLC9A3 SLC9A3 SLC25A4 SLC25A4 SLC33A1 SLC33A1 SLC9A7 SLC9A7 COX6A2 COX6A2 ATP5PF ATP5PF RNASEK RNASEK SLC46A1 SLC46A1 UCP1 UCP1 Atp6v1e1 Atp6v1e1 SLC25A22 SLC25A22 SLC25A18 SLC25A18 SURF1 SURF1 SLC15A1 SLC15A1 SLC4A11 SLC4A11 ATP6V0A2 ATP6V0A2 CLCN3 CLCN3 Atp5po Atp5po SLC9A9 SLC9A9 ATP5F1E ATP5F1E COX7B COX7B Atp5mg Atp5mg MFSD3 MFSD3 ATP6V1C2 ATP6V1C2 Atp5mc2 Atp5mc2 COX6A1 COX6A1 TCIRG1 TCIRG1 ATP5PD ATP5PD NNT NNT ATP6V1G3 ATP6V1G3 ATP6V1H ATP6V1H OTOP3 OTOP3 UCP3 UCP3 COX5A COX5A ATP1A2 ATP1A2 ATP6V1G2 ATP6V1G2 ATP12A ATP12A ATP4A ATP4A SLC11A2 SLC11A2 SLC9A1 SLC9A1 ATP6V0E1 ATP6V0E1 SLC9A4 SLC9A4 Atp6v0e2 Atp6v0e2 SLC25A13 SLC25A13 ATP5MC3 ATP5MC3 ENSCPOP00000026667 ENSCPOP00000026667 SLC9A8 SLC9A8 ATP6V1G1 ATP6V1G1 UQCRFS1 UQCRFS1 ATP6V0C ATP6V0C ENSCPOP00000026189 ENSCPOP00000026189 ATP6V0A4 ATP6V0A4 ATP1A1 ATP1A1 ENSCPOP00000025613 ENSCPOP00000025613 ATP6V1F ATP6V1F ENSCPOP00000025102 ENSCPOP00000025102 NDUFS7 NDUFS7 Atp5f1c Atp5f1c LOC100727437 LOC100727437 ATP1A4 ATP1A4 Atp5me Atp5me COX3 COX3 ND4 ND4 ND5 ND5 ATP6 ATP6 CYTB CYTB Slc45a4 Slc45a4 OTOP1 OTOP1 H0VZD4_CAVPO H0VZD4_CAVPO ATP5F1B ATP5F1B H0W0J8_CAVPO H0W0J8_CAVPO SLC45A3 SLC45A3 H0W3D2_CAVPO H0W3D2_CAVPO CTNS CTNS SLC15A4 SLC15A4 HVCN1 HVCN1 ATP6V1E2 ATP6V1E2 OTOP2 OTOP2 ATP5F1D ATP5F1D
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ATP6V1B2Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (511 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (67 aa)
COX2Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. (227 aa)
COX1Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (513 aa)
SLC45A1Solute carrier family 45 member 1. (700 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
SLC36A1Solute carrier family 36 member 1. (442 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (256 aa)
SLC9A6Solute carrier family 9 member A6. (643 aa)
SLC17A6Solute carrier family 17 member 6. (566 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (527 aa)
SLC4A10Anion exchange protein. (1118 aa)
ATP6V1AATPase H+ transporting V1 subunit A. (617 aa)
SLC11A1Solute carrier family 11 member 1. (541 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (736 aa)
B3GNTL1UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1. (357 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (799 aa)
SLC2A13Solute carrier family 2 member 13; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (560 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
SLC9B2Solute carrier family 9 member B2. (536 aa)
COX4I2Cytochrome c oxidase subunit 4I2. (170 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
COX15Cytochrome c oxidase assembly homolog COX15. (413 aa)
SLC36A3Solute carrier family 36 member 3. (426 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
SLC45A2Solute carrier family 45 member 2. (533 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SLC9C1Solute carrier family 9 member C1. (1134 aa)
ATP6V1DATPase H+ transporting V1 subunit D. (247 aa)
Atp5mc1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
ASIC5Acid sensing ion channel subunit family member 5; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (505 aa)
SLC32A1Solute carrier family 32 member 1. (526 aa)
SLC36A2Solute carrier family 36 member 2. (483 aa)
SLC9A2Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (724 aa)
ATP6V0BATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
TMCO3Transmembrane and coiled-coil domains 3. (694 aa)
SLC15A2Solute carrier family 15 member 2. (690 aa)
SLC17A7Solute carrier family 17 member 7. (560 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (832 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (727 aa)
COX6A2Cytochrome c oxidase subunit 6A, mitochondrial. (96 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
RNASEKRibonuclease K. (98 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
Atp6v1e1Uncharacterized protein. (226 aa)
SLC25A22Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
SLC25A18Solute carrier family 25 member 18; Belongs to the mitochondrial carrier (TC 2.A.29) family. (320 aa)
SURF1SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family. (302 aa)
SLC15A1Solute carrier family 15 member 1. (708 aa)
SLC4A11Solute carrier family 4 member 11. (881 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa)
CLCN3H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity); Belongs to the chloride channel (TC 2.A.49) family. ClC- 3/CLCN3 subfamily. (865 aa)
Atp5poUncharacterized protein. (219 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (644 aa)
ATP5F1EATP synthase F1 subunit epsilon. (51 aa)
COX7BCytochrome c oxidase subunit 7B. (80 aa)
Atp5mgATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
MFSD3Major facilitator superfamily domain containing 3. (408 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (437 aa)
Atp5mc2ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
COX6A1Cytochrome c oxidase subunit 6A, mitochondrial. (111 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
NNTNicotinamide nucleotide transhydrogenase. (1086 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa)
OTOP3Otopetrin 3. (580 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
COX5ACytochrome c oxidase subunit 5A. (150 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ATP6V1G2V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP12APotassium-transporting ATPase alpha chain 2; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues. (1072 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1034 aa)
SLC11A2Solute carrier family 11 member 2. (568 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (726 aa)
Atp6v0e2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
SLC25A13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (678 aa)
ATP5MC3Mitochondrial ATP synthase lipid-binding protein isoform A; Belongs to the ATPase C chain family. (141 aa)
ENSCPOP00000026667Uncharacterized protein. (62 aa)
SLC9A8Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (576 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (115 aa)
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
ENSCPOP00000026189Uncharacterized protein. (201 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
ENSCPOP00000025613Proton_antipo_M domain-containing protein. (171 aa)
ATP6V1FV-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa)
ENSCPOP00000025102Uncharacterized protein. (271 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (217 aa)
Atp5f1cATP synthase subunit gamma. (298 aa)
LOC100727437Uncharacterized protein. (782 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
Atp5meUncharacterized protein. (71 aa)
COX3Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex. (261 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (459 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (603 aa)
ATP6ATP synthase subunit a. (226 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa)
Slc45a4Uncharacterized protein. (815 aa)
OTOP1Otopetrin 1. (578 aa)
H0VZD4_CAVPOATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (487 aa)
H0W0J8_CAVPOUncharacterized protein. (71 aa)
SLC45A3Solute carrier family 45 member 3. (521 aa)
H0W3D2_CAVPOATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (122 aa)
CTNSCystinosin, lysosomal cystine transporter. (319 aa)
SLC15A4Solute carrier family 15 member 4. (577 aa)
HVCN1Hydrogen voltage gated channel 1. (283 aa)
ATP6V1E2ATPase H+ transporting V1 subunit E2. (226 aa)
OTOP2Otopetrin 2. (560 aa)
ATP5F1DATP synthase F1 subunit delta. (168 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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