STRINGSTRING
DRD2 DRD2 PIK3C2A PIK3C2A HECW1 HECW1 NEDD4 NEDD4 OSR1 OSR1 COMMD1 COMMD1 TMBIM6 TMBIM6 STOML1 STOML1 DRD3 DRD3 CACNB3 CACNB3 FMR1 FMR1 KCNAB1 KCNAB1 Ahr Ahr H0V5P5_CAVPO H0V5P5_CAVPO SLC43A1 SLC43A1 MMP9 MMP9 CLIC2 CLIC2 TGFB2 TGFB2 CRBN CRBN H0VBD1_CAVPO H0VBD1_CAVPO OXSR1 OXSR1 HECW2 HECW2 Cbarp Cbarp GEM GEM SRI SRI DYSF DYSF SLC43A2 SLC43A2 MTNR1B MTNR1B EPHB2 EPHB2 ISCU ISCU GNB5 GNB5 STK39 STK39 PPIF PPIF SLC30A1 SLC30A1 ACTN2 ACTN2 PKD2 PKD2 PCSK9 PCSK9 Sestd1 Sestd1 PRKCE PRKCE H0VXJ2_CAVPO H0VXJ2_CAVPO KCNH2 KCNH2 EPO EPO BCL2 BCL2 REM2 REM2 RRAD RRAD ATP7A ATP7A CACNA1F CACNA1F GRP GRP PTEN PTEN KEL KEL BIN1 BIN1 Fxyd2 Fxyd2 H0WD58_CAVPO H0WD58_CAVPO Drd4 Drd4 RGS2 RGS2 KCNE2 KCNE2 KCNE3 KCNE3 Sln Sln ENSCPOP00000023749 ENSCPOP00000023749 KCNE1 KCNE1 NEDD4L NEDD4L HAMP HAMP LOC100724130 LOC100724130 GPR35 GPR35 AKT1 AKT1 SLC9A3R1 SLC9A3R1 PLN PLN PTGER3 PTGER3 RGS4 RGS4 AGRN AGRN TRDN TRDN FKBP1B FKBP1B SNX27 SNX27 CAV1 CAV1 SUMO1 SUMO1 Vdac1 Vdac1 FGF12 FGF12 ENSCPOP00000029147 ENSCPOP00000029147 ATP1A2 ATP1A2 Ywhae Ywhae LOC101788042 LOC101788042 Ank3 Ank3 Cabp1 Cabp1 Camk2d Camk2d CAV3 CAV3 KCNE4 KCNE4 ENSCPOP00000031692 ENSCPOP00000031692 REM1 REM1 CASQ2 CASQ2 SLC6A9 SLC6A9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1404 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1579 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
TMBIM6Transmembrane BAX inhibitor motif containing 6; Belongs to the BI1 family. (237 aa)
STOML1Stomatin like 1. (406 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
FMR1Fragile X mental retardation 1. (612 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
AhrUncharacterized protein. (832 aa)
H0V5P5_CAVPOUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (385 aa)
SLC43A1Solute carrier family 43 member 1. (559 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (246 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
CRBNCereblon. (442 aa)
H0VBD1_CAVPO14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (105 aa)
OXSR1Oxidative stress responsive kinase 1. (526 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1566 aa)
CbarpUncharacterized protein. (691 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
SRISorcin. (198 aa)
DYSFDysferlin. (2103 aa)
SLC43A2Solute carrier family 43 member 2. (567 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (366 aa)
EPHB2EPH receptor B2. (949 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (166 aa)
GNB5G protein subunit beta 5. (406 aa)
STK39Serine/threonine kinase 39. (474 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
SLC30A1Solute carrier family 30 member 1. (448 aa)
ACTN2Actinin alpha 2. (894 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (686 aa)
Sestd1CRAL-TRIO domain-containing protein. (696 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1144 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (338 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
ATP7AATPase copper transporting alpha. (1433 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (143 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
KELKell metallo-endopeptidase (Kell blood group). (706 aa)
BIN1Bridging integrator 1. (577 aa)
Fxyd2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
H0WD58_CAVPOUncharacterized protein. (67 aa)
Drd4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (105 aa)
SlnUncharacterized protein. (31 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (125 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
LOC100724130TIR domain-containing protein. (1029 aa)
GPR35G protein-coupled receptor 35; Belongs to the G-protein coupled receptor 1 family. (327 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
AGRNAgrin. (1967 aa)
TRDNTriadin. (682 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
SNX27Sorting nexin 27. (541 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
Vdac1Uncharacterized protein. (283 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
Ywhae14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
LOC101788042C2 domain-containing protein. (110 aa)
Ank3Uncharacterized protein. (1948 aa)
Cabp1Uncharacterized protein. (227 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (174 aa)
ENSCPOP00000031692CRAL-TRIO domain-containing protein. (645 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (408 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (633 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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