STRINGSTRING
LYPLA1 LYPLA1 Abi3 Abi3 H0W1P6_CAVPO H0W1P6_CAVPO CAMK2B CAMK2B H0W0B4_CAVPO H0W0B4_CAVPO ARHGEF16 ARHGEF16 H0W027_CAVPO H0W027_CAVPO NHLRC1 NHLRC1 H0VYG8_CAVPO H0VYG8_CAVPO EPHA3 EPHA3 H0VXT9_CAVPO H0VXT9_CAVPO AR AR PPFIA1 PPFIA1 H0VWH7_CAVPO H0VWH7_CAVPO RANGRF RANGRF H0VVE5_CAVPO H0VVE5_CAVPO ZDHHC5 ZDHHC5 RHOG RHOG H0VUM6_CAVPO H0VUM6_CAVPO STX4 STX4 ARHGAP44 ARHGAP44 EFCAB7 EFCAB7 MAGI2 MAGI2 PRKCI PRKCI STX8 STX8 TNF TNF CACNG2 CACNG2 Vti1b Vti1b SORBS1 SORBS1 MAP2K1 MAP2K1 GRASP GRASP PDPK1 PDPK1 ITGA3 ITGA3 Vps4a Vps4a TREM2 TREM2 DPP10 DPP10 WNK3 WNK3 ZDHHC2 ZDHHC2 CNPY4 CNPY4 CLTC CLTC Csnk2a1 Csnk2a1 STAC3 STAC3 CAMK2A CAMK2A ZDHHC7 ZDHHC7 APPL1 APPL1 PIK3R1 PIK3R1 RHOQ RHOQ LZTFL1 LZTFL1 ARF6 ARF6 KIF5B KIF5B Dab2 Dab2 RACK1 RACK1 NUMA1 NUMA1 IQSEC2 IQSEC2 SAPCD2 SAPCD2 GOPC GOPC ADAM10 ADAM10 RAPGEF4 RAPGEF4 LYPLAL1 LYPLAL1 EPHB2 EPHB2 CNST CNST TNIK TNIK RSC1A1 RSC1A1 CLIP3 CLIP3 CDH1 CDH1 EPB41L2 EPB41L2 PGRMC1 PGRMC1 KALRN KALRN R3HDM1 R3HDM1 GRIPAP1 GRIPAP1 RAMP3 RAMP3 PRKCZ PRKCZ GHSR GHSR Myo5b Myo5b GSK3B GSK3B ABCA2 ABCA2 VAMP4 VAMP4 PKDCC PKDCC AGR2 AGR2 EGFR EGFR RAB11FIP2 RAB11FIP2 TMBIM1 TMBIM1 GPC4 GPC4 VAMP8 VAMP8 COMMD1 COMMD1 STAC STAC BCL2L1 BCL2L1 RAP1A RAP1A EZR EZR ENSCPOP00000032922 ENSCPOP00000032922 ACTR3 ACTR3 CDK5 CDK5 EPM2A EPM2A ENSCPOP00000032481 ENSCPOP00000032481 LOC100725073 LOC100725073 ENSCPOP00000032025 ENSCPOP00000032025 Misp Misp ITGB1 ITGB1 ACSL3 ACSL3 LDLRAP1 LDLRAP1 DPP6 DPP6 PLK1 PLK1 PLS1 PLS1 PRNP PRNP EPHA2 EPHA2 MRAP2 MRAP2 Camk2d Camk2d GNAI1 GNAI1 ENSCPOP00000029904 ENSCPOP00000029904 ATP2C1 ATP2C1 STX3 STX3 SPTBN1 SPTBN1 R3HDM2 R3HDM2 PPP1R9B PPP1R9B EPB41 EPB41 TMEM59 TMEM59 ENSCPOP00000028385 ENSCPOP00000028385 ENSCPOP00000028355 ENSCPOP00000028355 PID1 PID1 ENSCPOP00000028111 ENSCPOP00000028111 ENSCPOP00000027886 ENSCPOP00000027886 ENSCPOP00000027747 ENSCPOP00000027747 STX7 STX7 NKD2 NKD2 INS INS ENSCPOP00000026864 ENSCPOP00000026864 NUMB NUMB DAG1 DAG1 Cln3 Cln3 AKT1 AKT1 RER1 RER1 ENSCPOP00000025438 ENSCPOP00000025438 LRP1 LRP1 CLTCL1 CLTCL1 GPC6 GPC6 HECTD1 HECTD1 CIB1 CIB1 MYO5A MYO5A WNT3A WNT3A LYPD1 LYPD1 CSRP3 CSRP3 GPER1 GPER1 SQSTM1 SQSTM1 ATP2B4 ATP2B4 PPP2R5A PPP2R5A PICALM PICALM CSK CSK CAMK2G CAMK2G AP2M1 AP2M1 ENSCPOP00000022761 ENSCPOP00000022761 ACTB ACTB ENSCPOP00000022108 ENSCPOP00000022108 LGALS3 LGALS3 ENSCPOP00000021529 ENSCPOP00000021529 RAB11A RAB11A H0WD09_CAVPO H0WD09_CAVPO VIL1 VIL1 H0W9K9_CAVPO H0W9K9_CAVPO H0W7V2_CAVPO H0W7V2_CAVPO H0W5D4_CAVPO H0W5D4_CAVPO STAC2 STAC2 MMP14 MMP14 H0W4C9_CAVPO H0W4C9_CAVPO H0W3Y7_CAVPO H0W3Y7_CAVPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LYPLA1Lysophospholipase 1. (196 aa)
Abi3Abi_HHR domain-containing protein. (213 aa)
H0W1P6_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (539 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
H0W0B4_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (639 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (699 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1. (350 aa)
H0VYG8_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
EPHA3EPH receptor A3. (933 aa)
H0VXT9_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (546 aa)
ARAndrogen receptor. (926 aa)
PPFIA1PTPRF interacting protein alpha 1. (1267 aa)
H0VWH7_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (441 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
H0VVE5_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (528 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (716 aa)
RHOGRas homolog family member G. (191 aa)
H0VUM6_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (552 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (298 aa)
ARHGAP44Rho GTPase activating protein 44. (751 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
MAGI2Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1237 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (572 aa)
STX8Syntaxin 8. (236 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
Vti1bt-SNARE coiled-coil homology domain-containing protein. (232 aa)
SORBS1Sorbin and SH3 domain containing 1. (933 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GRASPGeneral receptor for phosphoinositides 1 associated scaffold protein. (324 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1048 aa)
Vps4aUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
DPP10Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (776 aa)
WNK3WNK lysine deficient protein kinase 3. (1746 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (323 aa)
CNPY4Canopy FGF signaling regulator 4. (250 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
Csnk2a1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
STAC3SH3 and cysteine rich domain 3. (363 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (698 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RHOQRas homolog family member Q. (195 aa)
LZTFL1Leucine zipper transcription factor like 1. (299 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (929 aa)
Dab2PID domain-containing protein. (766 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2117 aa)
IQSEC2IQ motif and Sec7 domain 2. (1242 aa)
SAPCD2Suppressor APC domain containing 2. (382 aa)
GOPCPDZ domain-containing protein. (461 aa)
ADAM10ADAM metallopeptidase domain 10. (679 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
LYPLAL1Lysophospholipase like 1. (239 aa)
EPHB2EPH receptor B2. (949 aa)
CNSTConsortin, connexin sorting protein. (714 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
RSC1A1Regulator of solute carriers 1. (608 aa)
CLIP3CAP-Gly domain containing linker protein 3. (547 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (891 aa)
EPB41L2Erythrocyte membrane protein band 4.1 like 2. (977 aa)
PGRMC1Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (195 aa)
KALRNKalirin RhoGEF kinase. (2964 aa)
R3HDM1R3H domain containing 1. (1127 aa)
GRIPAP1GRIP1 associated protein 1. (700 aa)
RAMP3Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL (By similarity). (192 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (593 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (302 aa)
Myo5bUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1803 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
ABCA2ATP binding cassette subfamily A member 2. (2427 aa)
VAMP4Vesicle associated membrane protein 4. (163 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (435 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (172 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
RAB11FIP2RAB11 family interacting protein 2. (523 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (309 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (547 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
STACSH3 and cysteine rich domain. (402 aa)
BCL2L1BCL2 like 1. (233 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
EZREzrin. (586 aa)
ENSCPOP00000032922Uncharacterized protein. (109 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (411 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
ENSCPOP00000032481Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (589 aa)
LOC100725073PID domain-containing protein. (745 aa)
ENSCPOP00000032025Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (631 aa)
MispUncharacterized protein. (774 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
DPP6Dipeptidyl peptidase like 6; Belongs to the peptidase S9B family. (864 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
PLS1Plastin 1. (630 aa)
PRNPMajor prion protein; Belongs to the prion family. (244 aa)
EPHA2EPH receptor A2. (976 aa)
MRAP2Melanocortin 2 receptor accessory protein 2. (207 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
GNAI1Uncharacterized protein. (330 aa)
ENSCPOP00000029904Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (633 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (977 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (288 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
R3HDM2R3H domain containing 2. (1039 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (821 aa)
EPB41Erythrocyte membrane protein band 4.1. (859 aa)
TMEM59Transmembrane protein 59. (323 aa)
ENSCPOP00000028385TPR_REGION domain-containing protein. (154 aa)
ENSCPOP00000028355Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (631 aa)
PID1Phosphotyrosine interaction domain containing 1. (217 aa)
ENSCPOP00000028111Uncharacterized protein; Belongs to the protein kinase superfamily. (348 aa)
ENSCPOP00000027886Uncharacterized protein; Belongs to the protein kinase superfamily. (455 aa)
ENSCPOP00000027747LAM_G_DOMAIN domain-containing protein. (151 aa)
STX7Syntaxin 7; Belongs to the syntaxin family. (278 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (440 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ENSCPOP00000026864V-SNARE coiled-coil homology domain-containing protein. (102 aa)
NUMBNUMB endocytic adaptor protein. (648 aa)
DAG1Dystroglycan 1. (891 aa)
Cln3Battenin. (438 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RER1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
ENSCPOP00000025438Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (589 aa)
LRP1LDL receptor related protein 1. (4508 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
GPC6Glypican 6; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (565 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2505 aa)
CIB1Calcium and integrin binding 1. (191 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1877 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
LYPD1LY6/PLAUR domain containing 1. (141 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SQSTM1Sequestosome 1. (415 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (660 aa)
CSKTyrosine-protein kinase. (450 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
ENSCPOP00000022761Uncharacterized protein; Belongs to the protein kinase superfamily. (451 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ENSCPOP00000022108Uncharacterized protein; Belongs to the protein kinase superfamily. (348 aa)
LGALS3Galectin. (244 aa)
ENSCPOP00000021529Uncharacterized protein. (112 aa)
RAB11AUncharacterized protein. (216 aa)
H0WD09_CAVPONon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (323 aa)
VIL1Villin 1. (827 aa)
H0W9K9_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (539 aa)
H0W7V2_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (555 aa)
H0W5D4_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (455 aa)
STAC2SH3 and cysteine rich domain 2. (402 aa)
MMP14Matrix metallopeptidase 14. (581 aa)
H0W4C9_CAVPOt-SNARE coiled-coil homology domain-containing protein. (224 aa)
H0W3Y7_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (503 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (20%) [HD]