STRINGSTRING
EPHB2 EPHB2 EPHA4 EPHA4 GSK3B GSK3B TLR4 TLR4 Parp1 Parp1 Foxo3 Foxo3 ADRB2 ADRB2 CACNA1A CACNA1A APP APP CACNA2D1 CACNA2D1 CACNB1 CACNB1 ENSCPOP00000024428 ENSCPOP00000024428 PSEN1 PSEN1 LRP1 LRP1 FYN FYN CD36 CD36 BCL2L2 BCL2L2 PRNP PRNP IGF1 IGF1 CDK5 CDK5 AGER AGER SIRT1 SIRT1 LGMN LGMN FCGR2 FCGR2 TREM2 TREM2 ABCC1 ABCC1 IGF1R IGF1R VCAM1 VCAM1 ITGA4 ITGA4 Atp1a3 Atp1a3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHB2EPH receptor B2. (949 aa)
EPHA4EPH receptor A4. (986 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
Foxo3Forkhead box O3. (660 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (641 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
LRP1LDL receptor related protein 1. (4508 aa)
FYNTyrosine-protein kinase. (537 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
BCL2L2BCL2 like 2. (193 aa)
PRNPMajor prion protein; Belongs to the prion family. (244 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
SIRT1Sirtuin 1. (717 aa)
LGMNLegumain. (436 aa)
FCGR2Low affinity immunoglobulin gamma Fc region receptor II; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. (341 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
ABCC1ATP binding cassette subfamily C member 1. (1531 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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