STRINGSTRING
CHD7 CHD7 PCGF1 PCGF1 STAT1 STAT1 GTF2F1 GTF2F1 MECP2 MECP2 PPARGC1A PPARGC1A SOX10 SOX10 ZNF683 ZNF683 ZC3H4 ZC3H4 LOC100718196 LOC100718196 GLI2 GLI2 ENSCPOP00000025226 ENSCPOP00000025226 FOXO4 FOXO4 IKZF3 IKZF3 DHX9 DHX9 TP53 TP53 NRL NRL MED1 MED1 KDM1A KDM1A ATF2 ATF2 SMAD3 SMAD3 ERCC1 ERCC1 GTF2B GTF2B HSF1 HSF1 ESR2 ESR2 TAF10 TAF10 HNRNPU HNRNPU E2F4 E2F4 TRIM33 TRIM33 ZNF750 ZNF750 H0VCZ7_CAVPO H0VCZ7_CAVPO NIPBL NIPBL HDAC1 HDAC1 MYBL1 MYBL1 DDX5 DDX5 RBL2 RBL2 NUP98 NUP98 ISL1 ISL1 Trim28 Trim28 TAF5 TAF5 WDR13 WDR13 H0V4A5_CAVPO H0V4A5_CAVPO ERCC4 ERCC4 EZH2 EZH2 ERCC3 ERCC3 PPARG PPARG ZNF609 ZNF609 SETDB1 SETDB1 RBL1 RBL1 SIRT1 SIRT1 MACROH2A1 MACROH2A1 L3MBTL2 L3MBTL2 SUZ12 SUZ12 IRF3 IRF3 Tro Tro ATF4 ATF4 DNMT1 DNMT1 PRDM15 PRDM15 PCGF2 PCGF2 FOXC2 FOXC2 EGR1 EGR1 MYOD1 MYOD1 NFE2L1 NFE2L1 ENSCPOP00000021738 ENSCPOP00000021738 POLR2A POLR2A EHMT2 EHMT2 HDAC2 HDAC2 PRDM1 PRDM1 POU4F2 POU4F2 HDAC4 HDAC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (522 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
SOX10SRY-box transcription factor 10. (469 aa)
ZNF683Zinc finger protein 683. (436 aa)
ZC3H4Zinc finger CCCH-type containing 4. (1218 aa)
LOC100718196Uncharacterized protein. (641 aa)
GLI2GLI family zinc finger 2. (1570 aa)
ENSCPOP00000025226Uncharacterized protein. (213 aa)
FOXO4Forkhead box O4. (505 aa)
IKZF3IKAROS family zinc finger 3. (510 aa)
DHX9DExH-box helicase 9. (1373 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
NRLLeucine zipper transcription factor. (237 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (865 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
GTF2BGeneral transcription factor IIB. (308 aa)
HSF1Heat shock transcription factor 1. (555 aa)
ESR2Estrogen receptor 2. (568 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (177 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (822 aa)
E2F4E2F transcription factor 4. (411 aa)
TRIM33Tripartite motif containing 33. (1128 aa)
ZNF750Zinc finger protein 750. (703 aa)
H0VCZ7_CAVPOFork-head domain-containing protein. (548 aa)
NIPBLNipped-B protein. (2721 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
MYBL1MYB proto-oncogene like 1. (749 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
RBL2RB transcriptional corepressor like 2. (1095 aa)
NUP98Nucleoporin 98. (1784 aa)
ISL1ISL LIM homeobox 1. (349 aa)
Trim28Uncharacterized protein. (829 aa)
TAF5TATA-box binding protein associated factor 5. (762 aa)
WDR13WD repeat domain 13. (485 aa)
H0V4A5_CAVPOUncharacterized protein. (830 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
ZNF609Zinc finger protein 609. (1409 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1290 aa)
RBL1RB transcriptional corepressor like 1. (1051 aa)
SIRT1Sirtuin 1. (717 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
L3MBTL2L3MBTL histone methyl-lysine binding protein 2. (716 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (737 aa)
IRF3Interferon regulatory factor 3. (389 aa)
TroMAGE domain-containing protein. (265 aa)
ATF4Activating transcription factor 4. (354 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1600 aa)
PRDM15PR/SET domain 15. (1084 aa)
PCGF2Polycomb group ring finger 2. (342 aa)
FOXC2Forkhead box C2. (441 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (535 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (318 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (743 aa)
ENSCPOP00000021738RING-type domain-containing protein. (326 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1833 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1188 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
PRDM1PR/SET domain 1. (813 aa)
POU4F2POU domain protein. (408 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1078 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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