11 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	SAMD8	Sterile alpha motif domain containing 8. (415 aa)
	ORMDL2	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	ORMDL3	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	ORMDL1	ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
	PLA2G6	Phospholipase A2 group VI. (803 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa)
	SPHK1	Sphingosine kinase 1. (386 aa)
	CCN1	Cellular communication network factor 1. (381 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
	SPHK2	Sphingosine kinase 2. (655 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PRKCD	SPHK1	ENSCPOP00000026102	ENSCPOP00000010964	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Sphingosine kinase 1.	0.573
PRKCD	SPHK2	ENSCPOP00000026102	ENSCPOP00000025777	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Sphingosine kinase 2.	0.535
SAMD8	SMPD3	ENSCPOP00000025792	ENSCPOP00000031780	Sterile alpha motif domain containing 8.	Sphingomyelin phosphodiesterase 3.	0.703
SAMD8	SPHK1	ENSCPOP00000025792	ENSCPOP00000010964	Sterile alpha motif domain containing 8.	Sphingosine kinase 1.	0.459
SAMD8	SPHK2	ENSCPOP00000025792	ENSCPOP00000025777	Sterile alpha motif domain containing 8.	Sphingosine kinase 2.	0.459
SMPD3	SAMD8	ENSCPOP00000031780	ENSCPOP00000025792	Sphingomyelin phosphodiesterase 3.	Sterile alpha motif domain containing 8.	0.703
SMPD3	SPHK1	ENSCPOP00000031780	ENSCPOP00000010964	Sphingomyelin phosphodiesterase 3.	Sphingosine kinase 1.	0.574
SMPD3	SPHK2	ENSCPOP00000031780	ENSCPOP00000025777	Sphingomyelin phosphodiesterase 3.	Sphingosine kinase 2.	0.563
SPHK1	PRKCD	ENSCPOP00000010964	ENSCPOP00000026102	Sphingosine kinase 1.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.573
SPHK1	SAMD8	ENSCPOP00000010964	ENSCPOP00000025792	Sphingosine kinase 1.	Sterile alpha motif domain containing 8.	0.459
SPHK1	SMPD3	ENSCPOP00000010964	ENSCPOP00000031780	Sphingosine kinase 1.	Sphingomyelin phosphodiesterase 3.	0.574
SPHK1	SPHK2	ENSCPOP00000010964	ENSCPOP00000025777	Sphingosine kinase 1.	Sphingosine kinase 2.	0.921
SPHK2	PRKCD	ENSCPOP00000025777	ENSCPOP00000026102	Sphingosine kinase 2.	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.535
SPHK2	SAMD8	ENSCPOP00000025777	ENSCPOP00000025792	Sphingosine kinase 2.	Sterile alpha motif domain containing 8.	0.459
SPHK2	SMPD3	ENSCPOP00000025777	ENSCPOP00000031780	Sphingosine kinase 2.	Sphingomyelin phosphodiesterase 3.	0.563
SPHK2	SPHK1	ENSCPOP00000025777	ENSCPOP00000010964	Sphingosine kinase 2.	Sphingosine kinase 1.	0.921