STRINGSTRING
HERC4 HERC4 TOP1 TOP1 RAI14 RAI14 OTP OTP WDR43 WDR43 Ccr2 Ccr2 CCDC137 CCDC137 MRI1 MRI1 DCLRE1A DCLRE1A FHIT FHIT NOP53 NOP53 RGS22 RGS22 PAK6 PAK6 SELENBP1 SELENBP1 UTP15 UTP15 SPATA2 SPATA2 Eif3l Eif3l FBL FBL MAP3K14 MAP3K14 RREB1 RREB1 RPAIN RPAIN NCL NCL RERG RERG CHCHD1 CHCHD1 ENSCPOP00000030866 ENSCPOP00000030866 ENSCPOP00000031793 ENSCPOP00000031793 SMUG1 SMUG1 ENSCPOP00000032877 ENSCPOP00000032877 EXOSC8 EXOSC8 NOLC1 NOLC1 URB1 URB1 APEX2 APEX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1030 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
RAI14Retinoic acid induced 14. (980 aa)
OTPOrthopedia homeobox. (325 aa)
WDR43WD repeat domain 43. (654 aa)
Ccr2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (371 aa)
CCDC137Coiled-coil domain containing 137. (282 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (362 aa)
DCLRE1ADNA cross-link repair 1A. (913 aa)
FHITBis(5'-adenosyl)-triphosphatase. (150 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (476 aa)
RGS22Regulator of G protein signaling 22. (1187 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SELENBP1Selenium binding protein 1. (471 aa)
UTP15UTP15 small subunit processome component. (517 aa)
SPATA2Spermatogenesis associated 2. (513 aa)
Eif3lEukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (607 aa)
FBLFibrillarin. (320 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (937 aa)
RREB1Ras responsive element binding protein 1. (1738 aa)
RPAINRPA interacting protein. (209 aa)
NCLNucleolin. (713 aa)
RERGRAS like estrogen regulated growth inhibitor. (199 aa)
CHCHD1Coiled-coil-helix-coiled-coil-helix domain containing 1. (118 aa)
ENSCPOP00000030866ANK_REP_REGION domain-containing protein. (133 aa)
ENSCPOP00000031793Uncharacterized protein. (352 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa)
ENSCPOP00000032877PCI domain-containing protein. (324 aa)
EXOSC8Exosome component 8. (276 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (732 aa)
URB1URB1 ribosome biogenesis homolog. (2253 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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