STRINGSTRING
ETAA1 ETAA1 FAN1 FAN1 RAD18 RAD18 HDAC2 HDAC2 TREX1 TREX1 Prim1 Prim1 Chek1 Chek1 H0VYV4_CAVPO H0VYV4_CAVPO SP8 SP8 RFC5 RFC5 DMAP1 DMAP1 MMS22L MMS22L TIMELESS TIMELESS ENSCPOP00000025455 ENSCPOP00000025455 RPA3 RPA3 Pola2 Pola2 DDAH2 DDAH2 H0UX17_CAVPO H0UX17_CAVPO BLM BLM TIPIN TIPIN H0W392_CAVPO H0W392_CAVPO POLD2 POLD2 CDT1 CDT1 DNMT1 DNMT1 H0WCZ5_CAVPO H0WCZ5_CAVPO POLD1 POLD1 Pold4 Pold4 SP9 SP9 RTF2 RTF2 UHRF1 UHRF1 ZMIZ2 ZMIZ2 TONSL TONSL POLA1 POLA1 PRIMPOL PRIMPOL WRN WRN PRIM2 PRIM2 RFC1 RFC1 DONSON DONSON TEX264 TEX264 Pold3 Pold3 MCM10 MCM10 PIF1 PIF1 RFC3 RFC3 RPA2 RPA2 CDC6 CDC6 H0VGS2_CAVPO H0VGS2_CAVPO DARS2 DARS2 RAD51B RAD51B SMARCAD1 SMARCAD1 SMARCAL1 SMARCAL1 XRCC2 XRCC2 RFC2 RFC2 C19orf53 C19orf53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ETAA1ETAA1 activator of ATR kinase. (866 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (987 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (493 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
H0VYV4_CAVPOUncharacterized protein. (260 aa)
SP8Sp8 transcription factor. (463 aa)
RFC5Replication factor C subunit 5. (340 aa)
DMAP1DNA methyltransferase 1 associated protein 1. (445 aa)
MMS22LMMS22 like, DNA repair protein. (1237 aa)
TIMELESSTimeless circadian regulator. (1239 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
RPA3Replication protein A3. (121 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (285 aa)
H0UX17_CAVPOBRCT domain-containing protein. (722 aa)
BLMBLM RecQ like helicase. (1405 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa)
H0W392_CAVPOAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (341 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
CDT1Chromatin licensing and DNA replication factor 1. (549 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1600 aa)
H0WCZ5_CAVPOAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (316 aa)
POLD1DNA polymerase. (1134 aa)
Pold4Uncharacterized protein. (107 aa)
SP9Sp9 transcription factor. (374 aa)
RTF2Replication termination factor 2. (308 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (781 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (920 aa)
TONSLTonsoku like, DNA repair protein. (1395 aa)
POLA1DNA polymerase. (1467 aa)
PRIMPOLPrimase and DNA directed polymerase. (547 aa)
WRNWRN RecQ like helicase. (1462 aa)
PRIM2DNA primase subunit 2. (432 aa)
RFC1Replication factor C subunit 1. (1153 aa)
DONSONDownstream neighbor of SON. (553 aa)
TEX264Testis expressed 264, ER-phagy receptor. (311 aa)
Pold3Uncharacterized protein. (466 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (834 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa)
RFC3Replication factor C subunit 3. (220 aa)
RPA2Replication protein A2. (270 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
H0VGS2_CAVPOUncharacterized protein. (611 aa)
DARS2Aspartyl-tRNA synthetase 2, mitochondrial. (654 aa)
RAD51BRAD51 paralog B. (258 aa)
SMARCAD1Uncharacterized protein. (1032 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa)
XRCC2X-ray repair cross complementing 2. (280 aa)
RFC2Replication factor C subunit 2. (352 aa)
C19orf53Chromosome 19 open reading frame 53. (99 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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