33 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Ank3	Uncharacterized protein. (1948 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
	SLC8A1	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
	SCN2A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
	SCN4B	Sodium voltage-gated channel beta subunit 4. (184 aa)
	AKAP6	A-kinase anchoring protein 6. (2208 aa)
	DSP	Desmoplakin. (2805 aa)
	CXADR	Uncharacterized protein. (356 aa)
	FHOD1	Formin homology 2 domain containing 1. (1190 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1754 aa)
	PKP2	Plakophilin 2. (835 aa)
	CTNNA3	Catenin alpha 3. (895 aa)
	RANGRF	RAN guanine nucleotide release factor. (186 aa)
	ANKRD23	Ankyrin repeat domain 23. (251 aa)
	SLC4A1	Anion exchange protein. (901 aa)
	VAMP5	Vesicle associated membrane protein 5. (100 aa)
	Gja1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	KCNA5	Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (609 aa)
	FXYD1	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	TLN2	Talin 2. (2542 aa)
	HAMP	Hepcidin antimicrobial peptide. (84 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
	ANK2	Ankyrin 2. (3876 aa)
	NRAP	Nebulin related anchoring protein. (1730 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
	TMEM65	Transmembrane protein 65. (196 aa)
	Camk2d	Protein kinase domain-containing protein. (532 aa)
	SCN5A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
	ENSCPOP00000032565	Uncharacterized protein. (1114 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK2	SCN2A	ENSCPOP00000026272	ENSCPOP00000002443	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.450
ANK2	SCN4B	ENSCPOP00000026272	ENSCPOP00000003457	Ankyrin 2.	Sodium voltage-gated channel beta subunit 4.	0.464
ANK2	SCN5A	ENSCPOP00000026272	ENSCPOP00000032395	Ankyrin 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.607
ANK2	SLC4A1	ENSCPOP00000026272	ENSCPOP00000016179	Ankyrin 2.	Anion exchange protein.	0.830
ATP1A1	ATP1A2	ENSCPOP00000025890	ENSCPOP00000029343	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.953
ATP1A1	FXYD1	ENSCPOP00000025890	ENSCPOP00000020673	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.816
ATP1A1	SLC9A1	ENSCPOP00000025890	ENSCPOP00000027947	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.563
ATP1A2	ATP1A1	ENSCPOP00000029343	ENSCPOP00000025890	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.953
ATP1A2	FXYD1	ENSCPOP00000029343	ENSCPOP00000020673	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.816
ATP1A2	SCN1A	ENSCPOP00000029343	ENSCPOP00000002422	Sodium/potassium-transporting ATPase subunit alpha.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.493
ATP1A2	SLC8A1	ENSCPOP00000029343	ENSCPOP00000002023	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...]	0.432
ATP1A2	SLC9A1	ENSCPOP00000029343	ENSCPOP00000027947	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.563
Ank3	SCN1A	ENSCPOP00000030036	ENSCPOP00000002422	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.505
Ank3	SCN2A	ENSCPOP00000030036	ENSCPOP00000002443	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.739
Ank3	SCN5A	ENSCPOP00000030036	ENSCPOP00000032395	Uncharacterized protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.702
Ank3	SLC4A1	ENSCPOP00000030036	ENSCPOP00000016179	Uncharacterized protein.	Anion exchange protein.	0.856
CTNNA3	PAK1	ENSCPOP00000012002	ENSCPOP00000000144	Catenin alpha 3.	Non-specific serine/threonine protein kinase.	0.518
CTNNA3	PKP2	ENSCPOP00000012002	ENSCPOP00000011103	Catenin alpha 3.	Plakophilin 2.	0.852
CTNNA3	TJP1	ENSCPOP00000012002	ENSCPOP00000009819	Catenin alpha 3.	Tight junction protein 1; Belongs to the MAGUK family.	0.938
CTNNA3	TLN2	ENSCPOP00000012002	ENSCPOP00000023493	Catenin alpha 3.	Talin 2.	0.820