STRINGSTRING
SLC2A4 SLC2A4 KCNN2 KCNN2 PRKAR2A PRKAR2A SLC8A1 SLC8A1 SCN1A SCN1A SCN2A SCN2A CACNB3 CACNB3 EDNRA EDNRA H0V4J9_CAVPO H0V4J9_CAVPO IGF1R IGF1R FER1L5 FER1L5 Cacnb2 Cacnb2 AKAP6 AKAP6 SRI SRI DYSF DYSF SLC30A1 SLC30A1 CACNG7 CACNG7 PRKCE PRKCE Kcnj12 Kcnj12 CACNG4 CACNG4 CAPN3 CAPN3 H0W649_CAVPO H0W649_CAVPO FXYD1 FXYD1 CACNA1S CACNA1S CACNA2D1 CACNA2D1 CACNG6 CACNG6 STBD1 STBD1 AKAP7 AKAP7 ANKRD52 ANKRD52 CACNA1C CACNA1C CACNB1 CACNB1 AQP4 AQP4 ATP2B4 ATP2B4 ATP1A1 ATP1A1 ANK2 ANK2 KCNJ5 KCNJ5 TGFB3 TGFB3 SLC9A1 SLC9A1 ATP1A2 ATP1A2 Camk2d Camk2d ABCC9 ABCC9 VDR VDR MSN MSN SCN5A SCN5A GOT2 GOT2 Kcnj3 Kcnj3 STAC STAC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (970 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FER1L5Fer-1 like family member 5. (2020 aa)
Cacnb2SH3 domain-containing protein. (621 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
SRISorcin. (198 aa)
DYSFDysferlin. (2103 aa)
SLC30A1Solute carrier family 30 member 1. (448 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
Kcnj12Uncharacterized protein. (535 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (779 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (257 aa)
STBD1Starch binding domain 1. (282 aa)
AKAP7A-kinase anchoring protein 7. (336 aa)
ANKRD52Ankyrin repeat domain 52. (1076 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
CACNB1Calcium voltage-gated channel auxiliary subunit beta 1. (641 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1048 aa)
ANK2Ankyrin 2. (3876 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
ABCC9ATP binding cassette subfamily C member 9. (1546 aa)
VDRVitamin D receptor. (424 aa)
MSNMoesin. (577 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
GOT2Aspartate aminotransferase. (430 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
STACSH3 and cysteine rich domain. (402 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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