STRINGSTRING
PDE4B PDE4B GRIA2 GRIA2 CALB1 CALB1 KCNN2 KCNN2 NEDD4 NEDD4 ATP6AP2 ATP6AP2 DNM3 DNM3 PTK2 PTK2 TENM2 TENM2 STRN4 STRN4 GRIA4 GRIA4 USP8 USP8 ESPN ESPN ITPKA ITPKA CANX CANX ADD1 ADD1 GRIA3 GRIA3 FMR1 FMR1 GRIA1 GRIA1 RGS14 RGS14 CTTNBP2 CTTNBP2 RGS10 RGS10 COMT COMT SYNDIG1 SYNDIG1 DOCK10 DOCK10 GRIN2B GRIN2B CAMK2A CAMK2A DVL1 DVL1 SLC1A3 SLC1A3 ABI2 ABI2 SLC1A2 SLC1A2 ARHGAP42 ARHGAP42 Srgap2 Srgap2 PPP1R1B PPP1R1B DTNBP1 DTNBP1 LRRC7 LRRC7 ITGA8 ITGA8 SLC8A2 SLC8A2 SRI SRI TRPV1 TRPV1 Atp1a3 Atp1a3 RAPGEF4 RAPGEF4 EPHB2 EPHB2 EPHA4 EPHA4 ASAP1 ASAP1 PPP1R9A PPP1R9A GRID2 GRID2 KCND2 KCND2 EEF2K EEF2K STRN STRN SYNPR SYNPR P2RX6 P2RX6 SLC1A1 SLC1A1 GRIN2A GRIN2A GRM3 GRM3 CYP19A1 CYP19A1 Myo5b Myo5b ALS2 ALS2 GSK3B GSK3B PTPRO PTPRO NR1D1 NR1D1 ANKS1B ANKS1B ARHGAP44 ARHGAP44 RPH3A RPH3A IGF2BP1 IGF2BP1 BCR BCR APBB1 APBB1 P2RX3 P2RX3 SHANK3 SHANK3 GRID2IP GRID2IP ATP2B2 ATP2B2 PTEN PTEN DBN1 DBN1 GIPC1 GIPC1 ARC ARC DLGAP3 DLGAP3 DRD5 DRD5 ASIC2 ASIC2 Drd4 Drd4 CACNA1S CACNA1S NTRK2 NTRK2 LRRC4 LRRC4 GABBR1 GABBR1 RAC1 RAC1 MT3 MT3 NSMF NSMF PPP1CA PPP1CA PTPRZ1 PTPRZ1 SHISA9 SHISA9 GPER1 GPER1 Pgr Pgr DLGAP2 DLGAP2 CYFIP1 CYFIP1 FXR1 FXR1 ARRB1 ARRB1 APBA1 APBA1 DRD1 DRD1 NOS1 NOS1 CLSTN1 CLSTN1 FRMPD4 FRMPD4 MYH10 MYH10 ABR ABR GRIN1 GRIN1 NRGN NRGN NUMB NUMB SEZ6 SEZ6 KCNA4 KCNA4 DNAJB1 DNAJB1 HPCA HPCA TANC2 TANC2 CNIH2 CNIH2 PPP1R9B PPP1R9B OPRD1 OPRD1 FUS FUS SLC8A3 SLC8A3 Chrna7 Chrna7 ATP1A2 ATP1A2 CRIPT CRIPT ARFGEF2 ARFGEF2 SYNPO SYNPO MPP2 MPP2 SIPA1L1 SIPA1L1 PTK2B PTK2B HPCAL1 HPCAL1 OPHN1 OPHN1 RHOA RHOA RAB8A RAB8A BAIAP2 BAIAP2 LZTS1 LZTS1 GRK2 GRK2 ARRB2 ARRB2 Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE4BPhosphodiesterase. (736 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
CALB1Calbindin 1. (275 aa)
KCNN2Potassium calcium-activated channel subfamily N member 2. (842 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (350 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
TENM2Teneurin transmembrane protein 2. (2765 aa)
STRN4Striatin 4. (777 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (819 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1081 aa)
ESPNEspin. (870 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (434 aa)
CANXCalnexin. (593 aa)
ADD1Adducin 1. (733 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (888 aa)
FMR1Fragile X mental retardation 1. (612 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (861 aa)
RGS14Regulator of G protein signaling 14. (570 aa)
CTTNBP2Cortactin binding protein 2. (1650 aa)
RGS10Regulator of G protein signaling 10. (182 aa)
COMTCatechol-O-methyltransferase. (292 aa)
SYNDIG1Synapse differentiation inducing 1. (250 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2198 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
DVL1Dishevelled segment polarity protein 1. (698 aa)
SLC1A3Amino acid transporter. (542 aa)
ABI2Abl interactor 2. (479 aa)
SLC1A2Amino acid transporter. (573 aa)
ARHGAP42Rho GTPase activating protein 42. (832 aa)
Srgap2Uncharacterized protein. (1063 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (184 aa)
DTNBP1Dystrobrevin binding protein 1. (354 aa)
LRRC7Leucine rich repeat containing 7. (1504 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
SRISorcin. (198 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
EPHB2EPH receptor B2. (949 aa)
EPHA4EPH receptor A4. (986 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1147 aa)
PPP1R9AProtein phosphatase 1 regulatory subunit 9A. (1288 aa)
GRID2Glutamate ionotropic receptor delta type subunit 2. (1007 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
EEF2KEukaryotic elongation factor 2 kinase. (724 aa)
STRNStriatin. (780 aa)
SYNPRSynaptoporin. (285 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (381 aa)
SLC1A1Amino acid transporter. (525 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
GRM3Glutamate metabotropic receptor 3. (877 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
Myo5bUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1803 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1580 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (611 aa)
ANKS1BAnkyrin repeat and sterile alpha motif domain containing 1B. (1260 aa)
ARHGAP44Rho GTPase activating protein 44. (751 aa)
RPH3ARabphilin 3A. (667 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (547 aa)
BCRBCR activator of RhoGEF and GTPase. (1227 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (709 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
GRID2IPGrid2 interacting protein. (1204 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (355 aa)
DBN1Drebrin 1. (677 aa)
GIPC1GIPC PDZ domain containing family member 1. (332 aa)
ARCActivity regulated cytoskeleton associated protein. (395 aa)
DLGAP3DLG associated protein 3. (979 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
Drd4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
NTRK2Tyrosine-protein kinase receptor. (816 aa)
LRRC4Leucine rich repeat containing 4. (652 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (844 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (66 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (513 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (1433 aa)
SHISA9Shisa family member 9. (424 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PgrUncharacterized protein. (428 aa)
DLGAP2DLG associated protein 2. (1058 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1264 aa)
FXR1FMR1 autosomal homolog 1. (677 aa)
ARRB1Arrestin beta 1. (430 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (837 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
NOS1Nitric oxide synthase 1. (1465 aa)
CLSTN1Calsyntenin 1. (989 aa)
FRMPD4FERM and PDZ domain containing 4. (1325 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
ABRABR activator of RhoGEF and GTPase. (859 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
NRGNNeurogranin. (78 aa)
NUMBNUMB endocytic adaptor protein. (648 aa)
SEZ6Seizure related 6 homolog. (994 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (622 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (339 aa)
HPCAHippocalcin. (193 aa)
TANC2Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (2013 aa)
CNIH2Cornichon family AMPA receptor auxiliary protein 2. (160 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (821 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
FUSFUS RNA binding protein. (490 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
Chrna7Uncharacterized protein. (483 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CRIPTCXXC repeat containing interactor of PDZ3 domain. (101 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1784 aa)
SYNPOSynaptopodin. (937 aa)
MPP2Membrane palmitoylated protein 2; Belongs to the MAGUK family. (569 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1803 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
HPCAL1Hippocalcin like 1. (193 aa)
OPHN1Uncharacterized protein. (802 aa)
RHOARas homolog family member A. (193 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
LZTS1Leucine zipper tumor suppressor 1. (606 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (750 aa)
ARRB2Arrestin beta 2. (417 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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