STRINGSTRING
Parp1 Parp1 WDR70 WDR70 NABP2 NABP2 OARD1 OARD1 RAD18 RAD18 PARP3 PARP3 HELB HELB SMARCAL1 SMARCAL1 SMARCAD1 SMARCAD1 SLFN5 SLFN5 Cgas Cgas EXD2 EXD2 INTS3 INTS3 HELQ HELQ PHF1 PHF1 SAMHD1 SAMHD1 UFL1 UFL1 KDM4D KDM4D POLL POLL PNKP PNKP APLF APLF TRAIP TRAIP RNF138 RNF138 WRAP53 WRAP53 Rad50 Rad50 WDR76 WDR76 KAT7 KAT7 H0UX17_CAVPO H0UX17_CAVPO ARPC1A ARPC1A SMCHD1 SMCHD1 SHLD2 SHLD2 ACTR3 ACTR3 TONSL TONSL IFFO1 IFFO1 NABP1 NABP1 ERCC6 ERCC6 ADPRHL2 ADPRHL2 SHLD1 SHLD1 LOC100728516 LOC100728516 CUL5 CUL5 SLF2 SLF2 POLK POLK RFWD3 RFWD3 ENSCPOP00000025800 ENSCPOP00000025800 RNF168 RNF168 ENSCPOP00000024830 ENSCPOP00000024830 IFFO2 IFFO2 ARPC5 ARPC5 ENSCPOP00000024428 ENSCPOP00000024428 TIMELESS TIMELESS CBX5 CBX5 NKX3-1 NKX3-1 ACTR2 ACTR2 LOC100736130 LOC100736130 AUNIP AUNIP ESCO2 ESCO2 CYREN CYREN PARP2 PARP2 PAXX PAXX WAS WAS H0VYV4_CAVPO H0VYV4_CAVPO H0VYM4_CAVPO H0VYM4_CAVPO Hrob Hrob Parp9 Parp9 RNF169 RNF169
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
WDR70WD repeat domain 70. (650 aa)
NABP2Nucleic acid binding protein 2. (227 aa)
OARD1O-acyl-ADP-ribose deacylase 1. (152 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (493 aa)
PARP3Poly [ADP-ribose] polymerase. (533 aa)
HELBDNA helicase B. (1063 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa)
SMARCAD1Uncharacterized protein. (1032 aa)
SLFN5Schlafen family member 5. (889 aa)
CgasMab-21 domain-containing protein. (387 aa)
EXD2Exonuclease 3'-5' domain containing 2. (619 aa)
INTS3Integrator complex subunit 3. (1007 aa)
HELQHelicase, POLQ like. (1054 aa)
PHF1PHD finger protein 1. (559 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa)
UFL1UFM1 specific ligase 1. (762 aa)
KDM4DLysine demethylase 4D. (512 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (523 aa)
APLFAprataxin and PNKP like factor. (498 aa)
TRAIPTRAF interacting protein. (469 aa)
RNF138Ring finger protein 138. (245 aa)
WRAP53WD repeat containing antisense to TP53. (541 aa)
Rad50Zinc-hook domain-containing protein. (1275 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (623 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (612 aa)
H0UX17_CAVPOBRCT domain-containing protein. (722 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa)
SHLD2Shieldin complex subunit 2. (905 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (411 aa)
TONSLTonsoku like, DNA repair protein. (1395 aa)
IFFO1Intermediate filament family orphan 1; Belongs to the intermediate filament family. (548 aa)
NABP1Nucleic acid binding protein 1. (204 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (367 aa)
SHLD1Shieldin complex subunit 1. (216 aa)
LOC100728516Uncharacterized protein. (346 aa)
CUL5Cullin 5; Belongs to the cullin family. (820 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1141 aa)
POLKDNA polymerase kappa. (540 aa)
RFWD3Ring finger and WD repeat domain 3. (764 aa)
ENSCPOP00000025800Uncharacterized protein. (348 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
ENSCPOP00000024830Uncharacterized protein. (331 aa)
IFFO2Intermediate filament family orphan 2; Belongs to the intermediate filament family. (499 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
TIMELESSTimeless circadian regulator. (1239 aa)
CBX5Chromobox 5. (191 aa)
NKX3-1NK3 homeobox 1. (224 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
LOC100736130Uncharacterized protein. (287 aa)
AUNIPAurora kinase A and ninein interacting protein. (351 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (597 aa)
CYRENCell cycle regulator of NHEJ. (180 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
PAXXPAXX non-homologous end joining factor. (206 aa)
WASWASP actin nucleation promoting factor. (505 aa)
H0VYV4_CAVPOUncharacterized protein. (260 aa)
H0VYM4_CAVPOUncharacterized protein. (503 aa)
HrobUncharacterized protein. (591 aa)
Parp9Uncharacterized protein. (703 aa)
RNF169Ring finger protein 169. (699 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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