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PRKCQ PRKCQ Rims1 Rims1 SYT6 SYT6 PLCH2 PLCH2 PKN2 PKN2 ABR ABR PRKCD PRKCD SYTL5 SYTL5 INPP4A INPP4A SMURF2 SMURF2 NEDD4L NEDD4L PRKCG PRKCG ENSCPOP00000024042 ENSCPOP00000024042 PLCB1 PLCB1 RAB11FIP2 RAB11FIP2 PLCD1 PLCD1 CAPN6 CAPN6 NEDD4 NEDD4 ITSN1 ITSN1 SYDE2 SYDE2 RIMS3 RIMS3 Cadps Cadps SYT1 SYT1 PLCG2 PLCG2 WWC2 WWC2 RPGRIP1 RPGRIP1 C2CD5 C2CD5 C2CD2 C2CD2 SYNGAP1 SYNGAP1 RASAL3 RASAL3 SYT2 SYT2 PRKCB PRKCB CPNE6 CPNE6 CPNE4 CPNE4 SYTL4 SYTL4 CAPN5 CAPN5 SYTL3 SYTL3 SYT9 SYT9 PLCH1 PLCH1 SYT11 SYT11 MCTP1 MCTP1 CC2D1B CC2D1B FER1L5 FER1L5 MCTP2 MCTP2 CADPS2 CADPS2 PIK3C2B PIK3C2B PLA2G4D PLA2G4D PLA2G4F PLA2G4F C2CD2L C2CD2L PLCZ1 PLCZ1 SYT10 SYT10 SYTL2 SYTL2 PLCD3 PLCD3 RIMS2 RIMS2 UNC13C UNC13C RASA3 RASA3 RASA1 RASA1 H0VB67_CAVPO H0VB67_CAVPO SYT13 SYT13 ESYT3 ESYT3 PLCL2 PLCL2 CPNE9 CPNE9 CPNE8 CPNE8 HECW2 HECW2 SYT5 SYT5 PCLO PCLO PLCE1 PLCE1 MYOF MYOF SYT4 SYT4 ESYT2 ESYT2 CC2D2A CC2D2A UVRAG UVRAG DYSF DYSF RIMS4 RIMS4 C2CD3 C2CD3 PLA2G4A PLA2G4A TC2N TC2N PLCL1 PLCL1 WWC1 WWC1 WWC3 WWC3 SYTL1 SYTL1 UNC13D UNC13D RPGRIP1L RPGRIP1L PLA2G4E PLA2G4E ITSN2 ITSN2 ITCH ITCH RASA2 RASA2 WWP1 WWP1 CPNE3 CPNE3 SYT14 SYT14 ESYT1 ESYT1 SYT3 SYT3 FER1L6 FER1L6 SMURF1 SMURF1 HECW1 HECW1 OTOF OTOF SYT12 SYT12 SYT7 SYT7 Rasa4b Rasa4b BAIAP3 BAIAP3 PRKCA PRKCA PLCD4 PLCD4 LOC106024982 LOC106024982 RPH3A RPH3A UNC13B UNC13B TOLLIP TOLLIP SYT8 SYT8 PLCB3 PLCB3 CPNE7 CPNE7 C2CD4C C2CD4C RAB11FIP5 RAB11FIP5 CPNE5 CPNE5 CPNE1 CPNE1 CEP120 CEP120 CPNE2 CPNE2 DOC2B DOC2B DOC2A DOC2A UNC13A UNC13A PRKCE PRKCE RASAL1 RASAL1 BCR BCR LOC100734527 LOC100734527 PLCG1 PLCG1 PKN1 PKN1 SYT17 SYT17 Rab11fip1 Rab11fip1 PRF1 PRF1 LOC101788042 LOC101788042 PLCB2 PLCB2 PLCB4 PLCB4 C2CD4D C2CD4D RASAL2 RASAL2 CC2D1A CC2D1A DAB2IP DAB2IP WWP2 WWP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (705 aa)
Rims1C2 domain-containing protein. (219 aa)
SYT6Synaptotagmin 6. (512 aa)
PLCH2Phosphoinositide phospholipase C. (1461 aa)
PKN2Protein kinase N2. (982 aa)
ABRABR activator of RhoGEF and GTPase. (859 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
SYTL5Synaptotagmin like 5. (715 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (972 aa)
SMURF2E3 ubiquitin-protein ligase. (782 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
ENSCPOP00000024042Uncharacterized protein. (143 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
RAB11FIP2RAB11 family interacting protein 2. (523 aa)
PLCD1Phosphoinositide phospholipase C. (755 aa)
CAPN6Calpain 6; Belongs to the peptidase C2 family. (641 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
ITSN1Intersectin 1. (1657 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1196 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
CadpsUncharacterized protein. (1363 aa)
SYT1Synaptotagmin 1. (422 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
WWC2WW and C2 domain containing 2. (1151 aa)
RPGRIP1RPGR interacting protein 1. (1117 aa)
C2CD5C2 calcium dependent domain containing 5. (1035 aa)
C2CD2C2 calcium dependent domain containing 2. (690 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1284 aa)
RASAL3RAS protein activator like 3. (1024 aa)
SYT2Synaptotagmin 2. (421 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
CPNE6Copine 6. (557 aa)
CPNE4Copine 4. (557 aa)
SYTL4Synaptotagmin like 4. (671 aa)
CAPN5Calpain 5; Belongs to the peptidase C2 family. (618 aa)
SYTL3Synaptotagmin like 3. (608 aa)
SYT9Synaptotagmin 9. (487 aa)
PLCH1Phosphoinositide phospholipase C. (1665 aa)
SYT11Synaptotagmin 11. (431 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (763 aa)
CC2D1BCoiled-coil and C2 domain containing 1B. (850 aa)
FER1L5Fer-1 like family member 5. (2020 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (865 aa)
CADPS2Calcium dependent secretion activator 2. (1179 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1633 aa)
PLA2G4DPhospholipase A2. (790 aa)
PLA2G4FPhospholipase A2. (842 aa)
C2CD2LC2CD2 like. (701 aa)
PLCZ1Phosphoinositide phospholipase C. (601 aa)
SYT10Synaptotagmin 10. (521 aa)
SYTL2Synaptotagmin like 2. (923 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1410 aa)
UNC13CUnc-13 homolog C. (2198 aa)
RASA3RAS p21 protein activator 3. (833 aa)
RASA1RAS p21 protein activator 1. (1024 aa)
H0VB67_CAVPOPhosphatidylinositol 3-kinase catalytic subunit type 3. (651 aa)
SYT13Synaptotagmin 13. (373 aa)
ESYT3Extended synaptotagmin 3. (884 aa)
PLCL2Phosphoinositide phospholipase C. (1009 aa)
CPNE9Copine family member 9. (553 aa)
CPNE8Copine 8. (516 aa)
HECW2HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. (1566 aa)
SYT5Synaptotagmin 5. (386 aa)
PCLOPiccolo presynaptic cytomatrix protein. (3548 aa)
PLCE1Phosphoinositide phospholipase C. (2282 aa)
MYOFMyoferlin. (2033 aa)
SYT4Synaptotagmin 4. (425 aa)
ESYT2Extended synaptotagmin 2. (763 aa)
CC2D2ACoiled-coil and C2 domain containing 2A. (1623 aa)
UVRAGUV radiation resistance associated. (698 aa)
DYSFDysferlin. (2103 aa)
RIMS4Regulating synaptic membrane exocytosis 4. (253 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2326 aa)
PLA2G4APhospholipase A2. (749 aa)
TC2NTandem C2 domains, nuclear. (487 aa)
PLCL1Phosphoinositide phospholipase C. (1011 aa)
WWC1WW and C2 domain containing 1. (1107 aa)
WWC3WWC family member 3. (1090 aa)
SYTL1Synaptotagmin like 1. (558 aa)
UNC13DUnc-13 homolog D. (1100 aa)
RPGRIP1LRPGRIP1 like. (1260 aa)
PLA2G4EPhospholipase A2. (805 aa)
ITSN2Intersectin 2. (1684 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
RASA2RAS p21 protein activator 2. (850 aa)
WWP1E3 ubiquitin-protein ligase. (912 aa)
CPNE3Copine 3. (523 aa)
SYT14Synaptotagmin 14. (587 aa)
ESYT1Extended synaptotagmin 1. (1092 aa)
SYT3Synaptotagmin 3. (587 aa)
FER1L6Fer-1 like family member 6. (1862 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1579 aa)
OTOFOtoferlin. (1980 aa)
SYT12Synaptotagmin 12. (421 aa)
SYT7Synaptotagmin 7. (556 aa)
Rasa4bUncharacterized protein. (802 aa)
BAIAP3BAI1 associated protein 3. (1152 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (601 aa)
PLCD4Phosphoinositide phospholipase C. (762 aa)
LOC106024982Phospholipase A2. (795 aa)
RPH3ARabphilin 3A. (667 aa)
UNC13BUnc-13 homolog B. (1959 aa)
TOLLIPToll interacting protein. (274 aa)
SYT8Synaptotagmin 8. (398 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
CPNE7Copine 7. (552 aa)
C2CD4CC2 calcium dependent domain containing 4C. (362 aa)
RAB11FIP5RAB11 family interacting protein 5. (636 aa)
CPNE5Copine 5. (593 aa)
CPNE1Copine 1. (537 aa)
CEP120Centrosomal protein 120. (952 aa)
CPNE2Copine 2. (548 aa)
DOC2BDouble C2 domain beta. (340 aa)
DOC2ADouble C2-like domain-containing protein. (401 aa)
UNC13AUnc-13 homolog A. (1650 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (736 aa)
RASAL1RAS protein activator like 1. (801 aa)
BCRBCR activator of RhoGEF and GTPase. (1227 aa)
LOC100734527Double C2-like domain-containing protein. (399 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
PKN1Protein kinase N1. (946 aa)
SYT17Synaptotagmin 17. (474 aa)
Rab11fip1Uncharacterized protein. (638 aa)
PRF1Perforin 1. (554 aa)
LOC101788042C2 domain-containing protein. (110 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
C2CD4DC2 calcium dependent domain containing 4D. (339 aa)
RASAL2RAS protein activator like 2. (1280 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (947 aa)
DAB2IPDAB2 interacting protein. (1193 aa)
WWP2E3 ubiquitin-protein ligase. (870 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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