24 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCPH1	Uncharacterized protein. (786 aa)
	PAXIP1	PAX interacting protein 1. (1037 aa)
	H0UX17_CAVPO	BRCT domain-containing protein. (722 aa)
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (502 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (956 aa)
	Pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (590 aa)
	RFC1	Replication factor C subunit 1. (1153 aa)
	ECT2	Epithelial cell transforming 2. (913 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (1061 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1104 aa)
	BARD1	BRCA1 associated RING domain 1. (662 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa)
	LIG3	DNA ligase. (1012 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
	LIG4	DNA ligase. (911 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1702 aa)
	POLM	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (485 aa)
	Parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (549 aa)
	SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1201 aa)
	PES1-2	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (563 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1392 aa)
	XRCC1	X-ray repair cross complementing 1. (629 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	CTDP1	ENSCPOP00000010340	ENSCPOP00000002374	BRCA1 associated RING domain 1.	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.407
BARD1	H0UX17_CAVPO	ENSCPOP00000010340	ENSCPOP00000001617	BRCA1 associated RING domain 1.	BRCT domain-containing protein.	0.864
BARD1	LIG4	ENSCPOP00000010340	ENSCPOP00000012853	BRCA1 associated RING domain 1.	DNA ligase.	0.475
BARD1	NBN	ENSCPOP00000010340	ENSCPOP00000012336	BRCA1 associated RING domain 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.997
BARD1	PARP4	ENSCPOP00000010340	ENSCPOP00000013221	BRCA1 associated RING domain 1.	Poly [ADP-ribose] polymerase.	0.406
BARD1	PAXIP1	ENSCPOP00000010340	ENSCPOP00000001180	BRCA1 associated RING domain 1.	PAX interacting protein 1.	0.927
BARD1	Parp1	ENSCPOP00000010340	ENSCPOP00000014109	BRCA1 associated RING domain 1.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.420
BARD1	REV1	ENSCPOP00000010340	ENSCPOP00000010779	BRCA1 associated RING domain 1.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.565
BARD1	RFC1	ENSCPOP00000010340	ENSCPOP00000003832	BRCA1 associated RING domain 1.	Replication factor C subunit 1.	0.745
BARD1	SLF1	ENSCPOP00000010340	ENSCPOP00000004512	BRCA1 associated RING domain 1.	SMC5-SMC6 complex localization factor 1.	0.998
BARD1	TOPBP1	ENSCPOP00000010340	ENSCPOP00000027324	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.997
CTDP1	BARD1	ENSCPOP00000002374	ENSCPOP00000010340	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	BRCA1 associated RING domain 1.	0.407
DNTT	LIG3	ENSCPOP00000002155	ENSCPOP00000011732	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA ligase.	0.732
DNTT	LIG4	ENSCPOP00000002155	ENSCPOP00000012853	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA ligase.	0.803
DNTT	PARP4	ENSCPOP00000002155	ENSCPOP00000013221	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Poly [ADP-ribose] polymerase.	0.527
DNTT	POLL	ENSCPOP00000002155	ENSCPOP00000004947	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.	0.664
DNTT	Parp1	ENSCPOP00000002155	ENSCPOP00000014109	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.555
DNTT	RFC1	ENSCPOP00000002155	ENSCPOP00000003832	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	Replication factor C subunit 1.	0.445
DNTT	XRCC1	ENSCPOP00000002155	ENSCPOP00000031519	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.	X-ray repair cross complementing 1.	0.886
H0UX17_CAVPO	BARD1	ENSCPOP00000001617	ENSCPOP00000010340	BRCT domain-containing protein.	BRCA1 associated RING domain 1.	0.864