STRINGSTRING
KCNJ8 KCNJ8 KCNH3 KCNH3 KCNJ6 KCNJ6 SCN3A SCN3A CLCN2 CLCN2 SCN4A SCN4A CLIC2 CLIC2 KCNV1 KCNV1 H0V4J9_CAVPO H0V4J9_CAVPO KCNA1 KCNA1 CACNA1B CACNA1B KCNC2 KCNC2 KCNH1 KCNH1 SCN2A SCN2A SCN1A SCN1A CACNG2 CACNG2 KCNH5 KCNH5 KCNA10 KCNA10 KCND3 KCND3 KCNH6 KCNH6 KCNB2 KCNB2 Kcnj3 Kcnj3 KCNA7 KCNA7 SCN5A SCN5A CACNA1D CACNA1D KCND1 KCND1 Kcnj2 Kcnj2 ENSCPOP00000030667 ENSCPOP00000030667 KCNJ16 KCNJ16 KCNV2 KCNV2 KCNB1 KCNB1 KCNA2 KCNA2 Kcng2 Kcng2 CLIC5 CLIC5 KCNA4 KCNA4 KCNJ5 KCNJ5 KCNJ10 KCNJ10 KCNG4 KCNG4 KCNH8 KCNH8 CLIC4 CLIC4 KCNE1 KCNE1 CACNG3 CACNG3 CACNG1 CACNG1 CACNA1C CACNA1C KCNG1 KCNG1 KCNS1 KCNS1 KCNA6 KCNA6 KCNE2 KCNE2 KCNJ15 KCNJ15 SCN11A SCN11A CACNG6 CACNG6 CACNA1S CACNA1S HCN2 HCN2 KCNH7 KCNH7 HCN4 HCN4 KCNJ9 KCNJ9 CACNA1G CACNA1G KCNJ11 KCNJ11 KCNH4 KCNH4 CACNA1A CACNA1A KCNA5 KCNA5 HCN3 HCN3 CLIC1 CLIC1 KCNJ1 KCNJ1 H0W649_CAVPO H0W649_CAVPO KCNF1 KCNF1 KCNC3 KCNC3 CACNA1F CACNA1F KCNS2 KCNS2 CACNG4 CACNG4 KCNH2 KCNH2 KCNJ4 KCNJ4 KCNJ14 KCNJ14 KCNS3 KCNS3 Kcnj12 Kcnj12 KCNQ1 KCNQ1 KCNA3 KCNA3 SCN8A SCN8A CACNG7 CACNG7 CACNA1E CACNA1E SCN7A SCN7A Kcnj13 Kcnj13 SCN10A SCN10A SCN9A SCN9A KCNC4 KCNC4 KCNG3 KCNG3 CACNA1I CACNA1I KCND2 KCND2 KCNC1 KCNC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ8Uncharacterized protein. (468 aa)
KCNH3Potassium voltage-gated channel subfamily H member 3. (1085 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (429 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)
CLCN2Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity); Belongs [...] (889 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1829 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (246 aa)
KCNV1Potassium voltage-gated channel modifier subfamily V member 1; Belongs to the potassium channel family. (502 aa)
H0V4J9_CAVPOUncharacterized protein. (291 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2270 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (418 aa)
KCNH1Uncharacterized protein. (989 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1965 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
KCNH5Potassium voltage-gated channel subfamily H member 5. (989 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
KCND3Potassium voltage-gated channel subfamily D member 3; Belongs to the potassium channel family. (654 aa)
KCNH6Potassium voltage-gated channel subfamily H member 6. (916 aa)
KCNB2Potassium voltage-gated channel subfamily B member 2; Belongs to the potassium channel family. (911 aa)
Kcnj3IRK_C domain-containing protein. (194 aa)
KCNA7Potassium voltage-gated channel subfamily A member 7; Belongs to the potassium channel family. (469 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (651 aa)
Kcnj2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Blocked b [...] (427 aa)
ENSCPOP00000030667Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (245 aa)
KCNJ16Inwardly-rectifying potassium channel Kir5.1. (419 aa)
KCNV2Potassium voltage-gated channel modifier subfamily V member 2; Belongs to the potassium channel family. (558 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
Kcng2Ion_trans domain-containing protein; Belongs to the potassium channel family. (235 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (622 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (379 aa)
KCNG4Potassium voltage-gated channel modifier subfamily G member 4; Belongs to the potassium channel family. (509 aa)
KCNH8Potassium voltage-gated channel subfamily H member 8. (1107 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (125 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
KCNG1Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family. (515 aa)
KCNS1Potassium voltage-gated channel modifier subfamily S member 1; Belongs to the potassium channel family. (497 aa)
KCNA6Potassium voltage-gated channel subfamily A member 6; Belongs to the potassium channel family. (491 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa)
KCNJ15ATP-sensitive inward rectifier potassium channel 15; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). (421 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1719 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (257 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1867 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (783 aa)
KCNH7Potassium voltage-gated channel subfamily H member 7. (1173 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1186 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] (390 aa)
KCNH4Potassium voltage-gated channel subfamily H member 4. (977 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (609 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (780 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (376 aa)
H0W649_CAVPOVoltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (280 aa)
KCNF1Potassium voltage-gated channel modifier subfamily F member 1; Belongs to the potassium channel family. (435 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (729 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
KCNS2Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family. (445 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (325 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1144 aa)
KCNJ4Uncharacterized protein. (443 aa)
KCNJ14Inwardly-rectifying potassium channel Kir2.4. (439 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
Kcnj12Uncharacterized protein. (535 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
KCNA3Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (528 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1876 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
SCN7ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1520 aa)
Kcnj13Inward rectifier potassium channel 13; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependen [...] (352 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
SCN9ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1986 aa)
KCNC4Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (594 aa)
KCNG3Potassium voltage-gated channel modifier subfamily G member 3; Belongs to the potassium channel family. (417 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2067 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.