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ADCY8 ADCY8 PRKAR2A PRKAR2A PRKAR2B PRKAR2B ADCY1 ADCY1 GNAL GNAL THAP7 THAP7 PRKAR1A PRKAR1A NBEA NBEA Gna15 Gna15 DCLK1 DCLK1 GNA14 GNA14 PTRHD1 PTRHD1 ADCY3 ADCY3 CAMK4 CAMK4 LRBA LRBA ADCY2 ADCY2 GNAI3 GNAI3 PRKAR1B PRKAR1B ADCY5 ADCY5 ADCY4 ADCY4 PDE1B PDE1B GNAT3 GNAT3 PLCB3 PLCB3 GNA11 GNA11 PLA2G4A PLA2G4A CAMK2G CAMK2G PLCB1 PLCB1 CNBD2 CNBD2 PRKCG PRKCG GNAI2 GNAI2 ADCY9 ADCY9 PRKCD PRKCD PRKACB PRKACB GNAQ GNAQ ADCY6 ADCY6 ADCY7 ADCY7 PLCB4 PLCB4 PDE1C PDE1C PLCB2 PLCB2 CAMKK1 CAMKK1 GNAI1 GNAI1 PDE1A PDE1A CAMKK2 CAMKK2 GRK2 GRK2 Prkaca Prkaca
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
ADCY1Adenylate cyclase 1. (944 aa)
GNALG protein subunit alpha L. (372 aa)
THAP7THAP domain containing 7. (309 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
NBEANeurobeachin. (2866 aa)
Gna15Uncharacterized protein. (205 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
GNA14G protein subunit alpha 14. (356 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
LRBALPS responsive beige-like anchor protein. (2861 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PDE1BPhosphodiesterase. (535 aa)
GNAT3G protein subunit alpha transducin 3. (354 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
PLA2G4APhospholipase A2. (749 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (587 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PDE1CPhosphodiesterase. (685 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (505 aa)
GNAI1Uncharacterized protein. (330 aa)
PDE1APhosphodiesterase. (531 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (565 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (750 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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