STRINGSTRING
FAM3C FAM3C IGF1 IGF1 TENM3 TENM3 LOC100732171 LOC100732171 VEGFC VEGFC PHACTR1 PHACTR1 ENSCPOP00000030693 ENSCPOP00000030693 LHFPL2 LHFPL2 CD9 CD9 VCL VCL LRRC55 LRRC55 VEGFB VEGFB SCCPDH SCCPDH LAMP2 LAMP2 APOOL APOOL CFL2 CFL2 EXOG EXOG ACTN1 ACTN1 CDC37L1 CDC37L1 IGF2 IGF2 SZRD1 SZRD1 TOR4A TOR4A FLNA FLNA CHID1 CHID1 TGFB3 TGFB3 CYB5R1 CYB5R1 Vegfa Vegfa TAGLN TAGLN CLPB CLPB ANXA4 ANXA4 OLA1 OLA1 SYTL5 SYTL5 CD36 CD36 CDNF CDNF SERPINF2 SERPINF2 ENSCPOP00000025226 ENSCPOP00000025226 ENSCPOP00000024842 ENSCPOP00000024842 ACTN4 ACTN4 LRRC38 LRRC38 ENSCPOP00000024537 ENSCPOP00000024537 SERPING1 SERPING1 TIMP3 TIMP3 ENSCPOP00000024015 ENSCPOP00000024015 LOC111753928 LOC111753928 LOC100721922 LOC100721922 SERPINE1 SERPINE1 TENM4 TENM4 TLN2 TLN2 TAGLN3 TAGLN3 ANXA5 ANXA5 ITIH3 ITIH3 LYRM7 LYRM7 F5 F5 ITGA2B ITGA2B APLP1 APLP1 CFD CFD MANF MANF TEX264 TEX264 CASC1 CASC1 MMRN1 MMRN1 DSTN DSTN PDGFB PDGFB F13A1 F13A1 SRGN SRGN WDR1 WDR1 PHACTR3 PHACTR3 TUBA4A TUBA4A SYTL3 SYTL3 VEGFD VEGFD LOC100721110 LOC100721110 SYTL4 SYTL4 PCYOX1L PCYOX1L APP APP CD37 CD37 ENDOG ENDOG H0W9R8_CAVPO H0W9R8_CAVPO Mug1 Mug1 SPARC SPARC TAGLN2 TAGLN2 ISLR ISLR TLNRD1 TLNRD1 H0W4C9_CAVPO H0W4C9_CAVPO TENM1 TENM1 CLEC3B CLEC3B LGALS3BP LGALS3BP HRG HRG ANXA11 ANXA11 STXBP2 STXBP2 SERBP1 SERBP1 GTPBP2 GTPBP2 Urb2 Urb2 CLU CLU Tro Tro CLUL1 CLUL1 CSMD1 CSMD1 Apf Apf Serpina3k Serpina3k ABCC4 ABCC4 FRZB FRZB THBS1 THBS1 SPP2 SPP2 Lefty2 Lefty2 BTBD9 BTBD9 ISLR2 ISLR2 NHLRC2 NHLRC2 SCG3 SCG3 ACTN2 ACTN2 PHACTR2 PHACTR2 TIMP1 TIMP1 ANXA3 ANXA3 LOC100733482 LOC100733482 FN1 FN1 KNG1 KNG1 A1AS_CAVPO A1AS_CAVPO SRL SRL QSOX2 QSOX2 PECAM1 PECAM1 APOH APOH APLP2 APLP2 CSMD3 CSMD3 LRRIQ4 LRRIQ4 PLG PLG Itgb3 Itgb3 FETUB FETUB LOC100728240 LOC100728240 PLEK PLEK FGA FGA PLEK2 PLEK2 Alb Alb CTSW CTSW FERMT3 FERMT3 Vti1b Vti1b PCYOX1 PCYOX1 ANXA7 ANXA7 LOC100723623 LOC100723623 HABP4 HABP4 ENDOD1 ENDOD1 QSOX1 QSOX1 IGSF3 IGSF3 TSPAN18 TSPAN18 LOC100714351 LOC100714351 PSAP PSAP LHFPL1 LHFPL1 TGFB1 TGFB1 AHSG AHSG TENM2 TENM2 EGF EGF PROS1 PROS1 HGF HGF TLN1 TLN1 LOC100720020 LOC100720020 ITIH4 ITIH4 A2M A2M SELP SELP LHFPL6 LHFPL6 GAS6 GAS6 Tmem211 Tmem211 Aldoa Aldoa CSMD2 CSMD2 CD109 CD109 TGFB2 TGFB2 GTPBP1 GTPBP1 F8 F8 Cfl1 Cfl1 GZMK GZMK FGG FGG ANXA10 ANXA10 Ly6g6f Ly6g6f FGB FGB CD63 CD63 PCDH7 PCDH7 ANXA13 ANXA13 BRPF3 BRPF3 SFRP4 SFRP4 TMX3 TMX3 RARRES2 RARRES2 ECM1 ECM1 RAB27B RAB27B ENSCPOP00000032955 ENSCPOP00000032955 FAM49B FAM49B PDGFA PDGFA APOA1 APOA1 BTBD19 BTBD19 PHACTR4 PHACTR4 Selenop Selenop ANXA9 ANXA9 Tmsb4x Tmsb4x
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAM3CFamily with sequence similarity 3 member C. (227 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
TENM3Teneurin transmembrane protein 3. (2715 aa)
LOC100732171C-X-C motif chemokine. (113 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
PHACTR1Phosphatase and actin regulator. (649 aa)
ENSCPOP00000030693Uncharacterized protein. (69 aa)
LHFPL2LHFPL tetraspan subfamily member 2. (228 aa)
CD9Tetraspanin. (227 aa)
VCLVinculin. (1134 aa)
LRRC55Leucine rich repeat containing 55. (328 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (206 aa)
SCCPDHSaccharopine dehydrogenase (putative). (430 aa)
LAMP2Lysosomal associated membrane protein 2. (408 aa)
APOOLMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (257 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
EXOGExo/endonuclease G. (358 aa)
ACTN1Actinin alpha 1. (914 aa)
CDC37L1Cell division cycle 37 like 1. (339 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
SZRD1SUZ RNA binding domain containing 1. (152 aa)
TOR4ATorsin family 4 member A. (413 aa)
FLNAFilamin A. (2645 aa)
CHID1Chitinase domain containing 1; Belongs to the glycosyl hydrolase 18 family. (398 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
VegfaVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (186 aa)
TAGLNTransgelin; Belongs to the calponin family. (201 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (705 aa)
ANXA4Annexin. (321 aa)
OLA1Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. (396 aa)
SYTL5Synaptotagmin like 5. (715 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
ENSCPOP00000025226Uncharacterized protein. (213 aa)
ENSCPOP00000024842Uncharacterized protein. (173 aa)
ACTN4Actinin alpha 4. (911 aa)
LRRC38Leucine rich repeat containing 38. (295 aa)
ENSCPOP00000024537Uncharacterized protein. (320 aa)
SERPING1SERPIN domain-containing protein; Belongs to the serpin family. (578 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
ENSCPOP00000024015Uncharacterized protein. (5460 aa)
LOC111753928Uncharacterized protein. (139 aa)
LOC100721922Uncharacterized protein; Belongs to the transferrin family. (700 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (476 aa)
TENM4Teneurin transmembrane protein 4. (2890 aa)
TLN2Talin 2. (2542 aa)
TAGLN3Transgelin; Belongs to the calponin family. (199 aa)
ANXA5Annexin. (318 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (889 aa)
LYRM7LYR motif containing 7; Belongs to the complex I LYR family. (104 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (1990 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1007 aa)
APLP1Amyloid beta precursor like protein 1. (653 aa)
CFDComplement factor D; Belongs to the peptidase S1 family. (216 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (180 aa)
TEX264Testis expressed 264, ER-phagy receptor. (311 aa)
CASC1Cancer susceptibility 1. (744 aa)
MMRN1Multimerin 1. (1215 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (164 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
F13A1Coagulation factor XIII A chain. (731 aa)
SRGNSerglycin. (167 aa)
WDR1WD_REPEATS_REGION domain-containing protein. (600 aa)
PHACTR3Phosphatase and actin regulator. (506 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
SYTL3Synaptotagmin like 3. (608 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (348 aa)
LOC100721110SERPIN domain-containing protein; Belongs to the serpin family. (418 aa)
SYTL4Synaptotagmin like 4. (671 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (494 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
CD37Tetraspanin. (281 aa)
ENDOGEndonuclease. (299 aa)
H0W9R8_CAVPOUncharacterized protein. (311 aa)
Mug1Uncharacterized protein. (1377 aa)
SPARCSecreted protein acidic and cysteine rich. (302 aa)
TAGLN2Transgelin; Belongs to the calponin family. (199 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (429 aa)
TLNRD1Talin rod domain containing 1. (355 aa)
H0W4C9_CAVPOt-SNARE coiled-coil homology domain-containing protein. (224 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
CLEC3BC-type lectin domain family 3 member B. (201 aa)
LGALS3BPGalectin 3 binding protein. (607 aa)
HRGHistidine rich glycoprotein. (467 aa)
ANXA11Annexin. (499 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (593 aa)
SERBP1SERPINE1 mRNA binding protein 1. (395 aa)
GTPBP2GTP binding protein 2. (602 aa)
Urb2Urb2 domain-containing protein. (968 aa)
CLUClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (447 aa)
TroMAGE domain-containing protein. (265 aa)
CLUL1Clusterin; Belongs to the clusterin family. (466 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
ApfAlpha-1-antiproteinase F; Inhibits elastase, chymotrypsin, cathepsin G, plasmin, and trypsin; Belongs to the serpin family. (405 aa)
Serpina3kSerine proteinase inhibitor A3K; Contrapsin inhibits trypsin-like proteases. (410 aa)
ABCC4ATP binding cassette subfamily C member 4. (1324 aa)
FRZBFrizzled related protein. (325 aa)
THBS1Thrombospondin 1. (1163 aa)
SPP2Secreted phosphoprotein 2. (204 aa)
Lefty2TGF_BETA_2 domain-containing protein. (291 aa)
BTBD9BTB domain containing 9. (614 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (748 aa)
NHLRC2NHL repeat containing 2. (726 aa)
SCG3Secretogranin III. (471 aa)
ACTN2Actinin alpha 2. (894 aa)
PHACTR2Phosphatase and actin regulator. (635 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
ANXA3Annexin. (323 aa)
LOC100733482Uncharacterized protein. (289 aa)
FN1Fibronectin 1. (2478 aa)
KNG1Kininogen 1. (625 aa)
A1AS_CAVPOAlpha-1-antiproteinase S; Inhibits elastase, chymotrypsin, cathepsin G, plasmin, and trypsin; Belongs to the serpin family. (405 aa)
SRLSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (472 aa)
QSOX2Sulfhydryl oxidase. (689 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (743 aa)
APOHApolipoprotein H. (235 aa)
APLP2Amyloid beta precursor like protein 2. (760 aa)
CSMD3CUB and Sushi multiple domains 3. (2998 aa)
LRRIQ4Leucine rich repeats and IQ motif containing 4. (573 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
FETUBFetuin B. (364 aa)
LOC100728240Uncharacterized protein. (1366 aa)
PLEKPleckstrin. (350 aa)
FGAFibrinogen alpha chain. (775 aa)
PLEK2Pleckstrin 2. (353 aa)
AlbPreproalbumin. (608 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (375 aa)
FERMT3Fermitin family member 3. (663 aa)
Vti1bt-SNARE coiled-coil homology domain-containing protein. (232 aa)
PCYOX1Prenylcysteine oxidase 1. (505 aa)
ANXA7Annexin. (456 aa)
LOC100723623Annexin. (327 aa)
HABP4Hyaluronan binding protein 4. (370 aa)
ENDOD1Endonuclease domain containing 1. (457 aa)
QSOX1Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. (613 aa)
IGSF3Immunoglobulin superfamily member 3. (1213 aa)
TSPAN18Tetraspanin. (248 aa)
LOC100714351SERPIN domain-containing protein; Belongs to the serpin family. (442 aa)
PSAPSaposin-C; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. (536 aa)
LHFPL1LHFPL tetraspan subfamily member 1. (220 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
AHSGAlpha-2-HS-glycoprotein. (358 aa)
TENM2Teneurin transmembrane protein 2. (2765 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
PROS1Protein S. (675 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
TLN1Talin 1. (2537 aa)
LOC100720020SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (899 aa)
A2MAlpha-2-macroglobulin. (1475 aa)
SELPSelectin P. (768 aa)
LHFPL6LHFPL tetraspan subfamily member 6. (200 aa)
GAS6Growth arrest specific 6. (678 aa)
Tmem211Uncharacterized protein. (200 aa)
AldoaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (416 aa)
CSMD2CUB and Sushi multiple domains 2. (3545 aa)
CD109CD109 molecule. (1402 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
GTPBP1GTP binding protein 1. (666 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2350 aa)
Cfl1Cofilin 1; Belongs to the actin-binding proteins ADF family. (218 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (260 aa)
FGGFibrinogen gamma chain. (445 aa)
ANXA10Annexin A10. (324 aa)
Ly6g6fIg-like domain-containing protein. (342 aa)
FGBFibrinogen beta chain. (479 aa)
CD63Tetraspanin. (238 aa)
PCDH7Protocadherin 7. (1256 aa)
ANXA13Annexin. (315 aa)
BRPF3Bromodomain and PHD finger containing 3. (1208 aa)
SFRP4Secreted frizzled related protein 4. (347 aa)
TMX3Thioredoxin related transmembrane protein 3. (452 aa)
RARRES2Retinoic acid receptor responder 2. (159 aa)
ECM1Extracellular matrix protein 1. (562 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
ENSCPOP00000032955Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (43 aa)
FAM49BFamily with sequence similarity 49 member B. (324 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (190 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
BTBD19BTB domain containing 19. (291 aa)
PHACTR4Phosphatase and actin regulator. (713 aa)
SelenopSelP_N domain-containing protein. (176 aa)
ANXA9Annexin. (345 aa)
Tmsb4xThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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