STRINGSTRING
KRAS KRAS ERBB4 ERBB4 FNDC3B FNDC3B NRG3 NRG3 ITCH ITCH WWP1 WWP1 ERBB3 ERBB3 NCSTN NCSTN NRG2 NRG2 SHC1 SHC1 NRG4 NRG4 GFAP GFAP H0WAD6_CAVPO H0WAD6_CAVPO BTC BTC H0WDT2_CAVPO H0WDT2_CAVPO STMN1 STMN1 PSEN1 PSEN1 ESR1 ESR1 HBEGF HBEGF NRAS NRAS EGFR EGFR APH1B APH1B Rps27a Rps27a APH1A APH1A PIK3CA PIK3CA ADAP1 ADAP1 WWOX WWOX PSEN2 PSEN2 EGF EGF NEDD4 NEDD4 UBA52 UBA52 NRG1 NRG1 MXD4 MXD4 HRAS HRAS Ubc Ubc CSDE1 CSDE1 ADAP2 ADAP2 PSENEN PSENEN UBB UBB EREG EREG ENSCPOP00000031632 ENSCPOP00000031632 GRB2 GRB2 FNDC3A FNDC3A SOS1 SOS1 PIK3R1 PIK3R1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KRASKRAS proto-oncogene, GTPase. (189 aa)
ERBB4Receptor protein-tyrosine kinase. (1263 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
NRG3Neuregulin 3. (600 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
WWP1E3 ubiquitin-protein ligase. (912 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1336 aa)
NCSTNNicastrin. (709 aa)
NRG2Neuregulin 2. (705 aa)
SHC1SHC adaptor protein 1. (583 aa)
NRG4Neuregulin 4. (84 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (431 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
BTCBetacellulin. (183 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
STMN1Stathmin; Belongs to the stathmin family. (149 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
ADAP1ArfGAP with dual PH domains 1. (354 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
NEDD4E3 ubiquitin-protein ligase. (896 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
NRG1Neuregulin 1. (700 aa)
MXD4MAX dimerization protein 4. (209 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
UbcUncharacterized protein. (159 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
ADAP2ArfGAP with dual PH domains 2. (369 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
EREGEpiregulin. (164 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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