STRINGSTRING
STAT3 STAT3 PTPN6 PTPN6 ENSCPOP00000025455 ENSCPOP00000025455 FYN FYN GRAP GRAP RAC1 RAC1 SRC SRC Fes Fes GRB7 GRB7 H0W027_CAVPO H0W027_CAVPO Stat5b Stat5b Chek1 Chek1 PIK3CA PIK3CA YES1 YES1 JAK2 JAK2 PTPN11 PTPN11 STAT1 STAT1 CMA1 CMA1 GAB2 GAB2 LOC100716811 LOC100716811 H0VKC6_CAVPO H0VKC6_CAVPO FNDC3A FNDC3A FER FER KITLG KITLG GRAP2 GRAP2 CBL CBL LOC100734206 LOC100734206 PTPRU PTPRU GRB2 GRB2 CSDE1 CSDE1 TEC TEC HRAS HRAS FNDC3B FNDC3B GRB10 GRB10 PIK3R1 PIK3R1 MMP9 MMP9 SH2B2 SH2B2 SH2B3 SH2B3 SOS1 SOS1 LYN LYN KIT KIT KRAS KRAS NRAS NRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (770 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
FYNTyrosine-protein kinase. (537 aa)
GRAPGRB2 related adaptor protein. (217 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
SRCTyrosine-protein kinase. (542 aa)
FesF-BAR domain-containing protein. (95 aa)
GRB7Growth factor receptor bound protein 7. (531 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
Stat5bSignal transducer and activator of transcription. (786 aa)
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
YES1Tyrosine-protein kinase. (541 aa)
JAK2Tyrosine-protein kinase. (1035 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
STAT1Signal transducer and activator of transcription. (799 aa)
CMA1Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. (247 aa)
GAB2GRB2 associated binding protein 2. (635 aa)
LOC100716811Signal transducer and activator of transcription. (795 aa)
H0VKC6_CAVPOFibronectin type-II domain-containing protein. (75 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (271 aa)
GRAP2GRB2 related adaptor protein 2. (327 aa)
CBLCbl proto-oncogene. (894 aa)
LOC100734206Uncharacterized protein. (461 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1504 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
TECTyrosine-protein kinase. (631 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
GRB10Growth factor receptor bound protein 10. (616 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
MMP9Matrix metallopeptidase 9. (715 aa)
SH2B2SH2B adaptor protein 2. (634 aa)
SH2B3SH2B adaptor protein 3. (557 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
LYNTyrosine-protein kinase. (512 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.