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CHCHD3 CHCHD3 ENSCPOP00000025102 ENSCPOP00000025102 SIRT5 SIRT5 ENSCPOP00000024366 ENSCPOP00000024366 Atp5f1c Atp5f1c Atp5me Atp5me PPARGC1A PPARGC1A ATP5F1D ATP5F1D SOD2 SOD2 SIRT3 SIRT3 CUNH17orf80 CUNH17orf80 H0W3D2_CAVPO H0W3D2_CAVPO MICOS13 MICOS13 H0W0J8_CAVPO H0W0J8_CAVPO ATP5F1B ATP5F1B H0VZD4_CAVPO H0VZD4_CAVPO ATP6 ATP6 GABPB1 GABPB1 DNAJC11 DNAJC11 CRTC3 CRTC3 MICOS10 MICOS10 IDH2 IDH2 Atp5mc1 Atp5mc1 NRF1 NRF1 MTX2 MTX2 GABPB2 GABPB2 ATP5PD ATP5PD Atp5mc2 Atp5mc2 CHCHD6 CHCHD6 LOC100731649 LOC100731649 Atp5mg Atp5mg ATP5F1E ATP5F1E SIRT4 SIRT4 IMMT IMMT ATP5F1A ATP5F1A CRTC2 CRTC2 ATP8 ATP8 DMAC2L DMAC2L ATP5PB ATP5PB TFB1M TFB1M TMEM11 TMEM11 GABPA GABPA PPRC1 PPRC1 ENSCPOP00000025638 ENSCPOP00000025638 LOC100724240 LOC100724240 ENSCPOP00000027951 ENSCPOP00000027951 ATP5MC3 ATP5MC3 ENSCPOP00000025873 ENSCPOP00000025873 ENSCPOP00000025801 ENSCPOP00000025801 Atp5po Atp5po TWNK TWNK PPARGC1B PPARGC1B SSBP1 SSBP1 ACSS2 ACSS2 Apoo Apoo SRFBP1 SRFBP1 ATP5PF ATP5PF Glud1 Glud1 POLG2 POLG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHCHD3MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (227 aa)
ENSCPOP00000025102Uncharacterized protein. (271 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (309 aa)
ENSCPOP00000024366Uncharacterized protein. (49 aa)
Atp5f1cATP synthase subunit gamma. (298 aa)
Atp5meUncharacterized protein. (71 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
ATP5F1DATP synthase F1 subunit delta. (168 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (257 aa)
CUNH17orf80Uncharacterized protein. (118 aa)
H0W3D2_CAVPOATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (122 aa)
MICOS13MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (118 aa)
H0W0J8_CAVPOUncharacterized protein. (71 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (487 aa)
H0VZD4_CAVPOATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
ATP6ATP synthase subunit a. (226 aa)
GABPB1GA binding protein transcription factor subunit beta 1. (333 aa)
DNAJC11DnaJ heat shock protein family (Hsp40) member C11. (559 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
MICOS10MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (78 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
Atp5mc1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
NRF1Nuclear respiratory factor 1. (457 aa)
MTX2Metaxin 2. (252 aa)
GABPB2GA binding protein transcription factor subunit beta 2. (452 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (161 aa)
Atp5mc2ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
CHCHD6MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (289 aa)
LOC100731649Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Atp5mgATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
ATP5F1EATP synthase F1 subunit epsilon. (51 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (753 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (527 aa)
CRTC2CREB regulated transcription coactivator 2. (692 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (67 aa)
DMAC2LDistal membrane arm assembly complex 2 like. (200 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (256 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (346 aa)
TMEM11Transmembrane protein 11. (192 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
PPRC1PPARG related coactivator 1. (1661 aa)
ENSCPOP00000025638Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC100724240Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
ENSCPOP00000027951Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (92 aa)
ATP5MC3Mitochondrial ATP synthase lipid-binding protein isoform A; Belongs to the ATPase C chain family. (141 aa)
ENSCPOP00000025873Cytochrome c domain-containing protein; Belongs to the cytochrome c family. (92 aa)
ENSCPOP00000025801MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (173 aa)
Atp5poUncharacterized protein. (219 aa)
TWNKTwinkle mtDNA helicase. (670 aa)
PPARGC1BPPARG coactivator 1 beta. (1028 aa)
SSBP1Single stranded DNA binding protein 1. (137 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (713 aa)
ApooMICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (198 aa)
SRFBP1Serum response factor binding protein 1. (429 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
Glud1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (540 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (482 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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