STRINGSTRING
Cacnb2 Cacnb2 TKT TKT ADIPOR1 ADIPOR1 SLC2A1 SLC2A1 PRKAR2A PRKAR2A ABCC8 ABCC8 ACSL4 ACSL4 TALDO1 TALDO1 FASN FASN PRKAR2B PRKAR2B RAPGEF5 RAPGEF5 MLXIP MLXIP THAP7 THAP7 CACNB3 CACNB3 KCNC2 KCNC2 PRKAR1A PRKAR1A ACACB ACACB Gna15 Gna15 ADIPOR2 ADIPOR2 GNA14 GNA14 GNB1 GNB1 ACACA ACACA GNGT1 GNGT1 SYT5 SYT5 H0VE70_CAVPO H0VE70_CAVPO PRKAA2 PRKAA2 GNG13 GNG13 MLXIPL MLXIPL RAPGEF4 RAPGEF4 TKTL1 TKTL1 FAP FAP SLC2A2 SLC2A2 ITPR2 ITPR2 PRKAR1B PRKAR1B GNB5 GNB5 ADCY5 ADCY5 CACNA1E CACNA1E LOC100721783 LOC100721783 GLP1R GLP1R PRKAG2 PRKAG2 GCG GCG Ffar1 Ffar1 KCNS3 KCNS3 GNB2 GNB2 GCGR GCGR GNB3 GNB3 CACNA1F CACNA1F ADRA2A ADRA2A CACNA2D2 CACNA2D2 TKTL2 TKTL2 ITPR3 ITPR3 CACNA1A CACNA1A KCNJ11 KCNJ11 H0WBW4_CAVPO H0WBW4_CAVPO PLCB3 PLCB3 GNA11 GNA11 CACNA2D1 CACNA2D1 GNG3 GNG3 GNG7 GNG7 CACNA1C CACNA1C PLCB1 PLCB1 CNBD2 CNBD2 AGPAT1 AGPAT1 GNG2 GNG2 RAPGEF3 RAPGEF3 GNG11 GNG11 GNB4 GNB4 GNAI2 GNAI2 CD36 CD36 MLX MLX GNG12 GNG12 Gng5 Gng5 PRKACB PRKACB GNAQ GNAQ ADIPOQ ADIPOQ GNG8 GNG8 ADCY6 ADCY6 Kcng2 Kcng2 KCNB1 KCNB1 GNG4 GNG4 PRKAB2 PRKAB2 PLCB2 PLCB2 GNAI1 GNAI1 ENSCPOP00000030509 ENSCPOP00000030509 ITPR1 ITPR1 RAPGEFL1 RAPGEFL1 GNGT2 GNGT2 LOC100732436 LOC100732436 ENSCPOP00000031524 ENSCPOP00000031524 ACSL3 ACSL3 CACNA1D CACNA1D Prkaca Prkaca RAP1A RAP1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cacnb2SH3 domain-containing protein. (621 aa)
TKTTransketolase. (592 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
ABCC8ATP binding cassette subfamily C member 8. (1549 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (707 aa)
TALDO1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
FASNFatty acid synthase. (2530 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
RAPGEF5Rap guanine nucleotide exchange factor 5. (811 aa)
MLXIPMLX interacting protein. (940 aa)
THAP7THAP domain containing 7. (309 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
KCNC2Potassium voltage-gated channel subfamily C member 2; Belongs to the potassium channel family. (418 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
Gna15Uncharacterized protein. (205 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
GNA14G protein subunit alpha 14. (356 aa)
GNB1Beta-transducin. (340 aa)
ACACAAcetyl-CoA carboxylase alpha. (2393 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
SYT5Synaptotagmin 5. (386 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GNG13G protein subunit gamma 13. (67 aa)
MLXIPLMLX interacting protein like. (854 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
TKTL1Transketolase like 1. (597 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (725 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
GNB5G protein subunit beta 5. (406 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
LOC100721783G_PROTEIN_RECEP_F1_2 domain-containing protein. (300 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] (180 aa)
Ffar1annotation not available (300 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
GNB2G protein subunit beta 2. (378 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (481 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). (402 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1129 aa)
TKTL2Transketolase like 2. (627 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] (390 aa)
H0WBW4_CAVPOGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1227 aa)
GNA11G protein subunit alpha 11. (345 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1078 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (587 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (284 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNB4G protein subunit beta 4. (340 aa)
GNAI2Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity). Belongs to the G-alpha family. G(i/o/t/z) subfamily. (355 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
MLXMAX dimerization protein MLX. (244 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
Gng5G protein gamma domain-containing protein. (41 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
GNAQG protein subunit alpha q. (313 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (247 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
Kcng2Ion_trans domain-containing protein; Belongs to the potassium channel family. (235 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (855 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
GNAI1Uncharacterized protein. (330 aa)
ENSCPOP00000030509Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
RAPGEFL1Rap guanine nucleotide exchange factor like 1. (646 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
LOC100732436Uncharacterized protein. (327 aa)
ENSCPOP00000031524Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (100 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2164 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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