STRINGSTRING
H0WAS6_CAVPO H0WAS6_CAVPO MAP2K3 MAP2K3 FNBP4 FNBP4 UBA52 UBA52 Usp18 Usp18 AGER AGER IRAK2 IRAK2 PPP4R1 PPP4R1 LRRC71 LRRC71 VWC2 VWC2 TAB3 TAB3 TRAF6 TRAF6 NFKB2 NFKB2 PPP2CB PPP2CB NFKBIA NFKBIA Rps27a Rps27a RIPK2 RIPK2 DUSP7 DUSP7 NFKB1 NFKB1 ALPK1 ALPK1 LOC100734047 LOC100734047 ELK1 ELK1 IKBKB IKBKB PPP2R5D PPP2R5D NLRC5 NLRC5 LRRC74A LRRC74A LRRC34 LRRC34 MAPK1 MAPK1 LOC106026468 LOC106026468 NFKBIB NFKBIB MAPK15 MAPK15 CREB5 CREB5 LRRC45 LRRC45 PPP4R4 PPP4R4 UBE2V1 UBE2V1 MAP2K4 MAP2K4 TAB2 TAB2 MAP3K1 MAP3K1 RPS6KA5 RPS6KA5 RELCH RELCH LRRC14 LRRC14 CASP10 CASP10 MAPKAPK2 MAPKAPK2 MAP2K7 MAP2K7 RELA RELA ECSIT ECSIT TIRAP TIRAP H0W160_CAVPO H0W160_CAVPO N4BP1 N4BP1 VRK3 VRK3 KHNYN KHNYN MAPK7 MAPK7 H0WAD6_CAVPO H0WAD6_CAVPO IKBKG IKBKG TAB1 TAB1 APP APP JUN JUN H0WDT2_CAVPO H0WDT2_CAVPO CREB1 CREB1 MAPKAPK3 MAPKAPK3 LOC100718750 LOC100718750 FOS FOS MAP2K6 MAP2K6 MAPK14 MAPK14 RPS6KA2 RPS6KA2 RPS6KA3 RPS6KA3 RPS6KA1 RPS6KA1 ENSCPOP00000023362 ENSCPOP00000023362 USP14 USP14 Hmgb1 Hmgb1 MAPK11 MAPK11 DUSP6 DUSP6 MAPK3 MAPK3 PPP2CA PPP2CA NKIRAS1 NKIRAS1 MAPK8 MAPK8 NOD1 NOD1 PPP2R1B PPP2R1B SIGIRR SIGIRR FOSL2 FOSL2 MAPK9 MAPK9 MAP3K7 MAP3K7 Atf7 Atf7 TRAF2 TRAF2 DUSP4 DUSP4 S100B S100B TIFA TIFA ENSCPOP00000027005 ENSCPOP00000027005 LRRC74B LRRC74B NLRX1 NLRX1 ENSCPOP00000029546 ENSCPOP00000029546 UBB UBB PELI3 PELI3 PELI1 PELI1 CASP8 CASP8 ATF1 ATF1 MAP3K20 MAP3K20 ENSCPOP00000030838 ENSCPOP00000030838 ATF2 ATF2 NKIRAS2 NKIRAS2 Dusp3 Dusp3 ENSCPOP00000031632 ENSCPOP00000031632 Ubc Ubc CHUK CHUK ENSCPOP00000032088 ENSCPOP00000032088 IRAK1 IRAK1 NOD2 NOD2 PELI2 PELI2 TONSL TONSL MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0WAS6_CAVPOUncharacterized protein. (214 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
FNBP4Formin binding protein 4. (1044 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
Usp18USP domain-containing protein; Belongs to the peptidase C19 family. (158 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (606 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (942 aa)
LRRC71Leucine rich repeat containing 71. (548 aa)
VWC2Von Willebrand factor C domain containing 2. (315 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
NFKB2Nuclear factor kappa B subunit 2. (854 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
NFKB1Nuclear factor kappa B subunit 1. (967 aa)
ALPK1Alpha kinase 1. (1117 aa)
LOC100734047Uncharacterized protein. (567 aa)
ELK1ETS transcription factor ELK1. (422 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (594 aa)
NLRC5NLR family CARD domain containing 5. (1831 aa)
LRRC74ALeucine rich repeat containing 74A. (465 aa)
LRRC34Leucine rich repeat containing 34. (448 aa)
MAPK1Mitogen-activated protein kinase. (325 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
NFKBIBNFKB inhibitor beta. (355 aa)
MAPK15Mitogen-activated protein kinase. (539 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (461 aa)
LRRC45Leucine rich repeat containing 45. (669 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (832 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (145 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (386 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (665 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1370 aa)
RPS6KA5Ribosomal protein S6 kinase. (835 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1097 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (474 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (383 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (459 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
ECSITECSIT signalling integrator. (431 aa)
TIRAPTIR domain containing adaptor protein. (221 aa)
H0W160_CAVPOUncharacterized protein. (589 aa)
N4BP1NEDD4 binding protein 1. (886 aa)
VRK3VRK serine/threonine kinase 3. (402 aa)
KHNYNKH and NYN domain containing. (657 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (797 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (507 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (380 aa)
LOC100718750Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa)
Hmgb1annotation not available (215 aa)
MAPK11Mitogen-activated protein kinase. (385 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (873 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (696 aa)
SIGIRRSingle Ig and TIR domain containing. (408 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
Atf7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (411 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
LRRC74BLeucine rich repeat containing 74B. (380 aa)
NLRX1NLR family member X1. (976 aa)
ENSCPOP00000029546UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
ATF1Activating transcription factor 1. (269 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (711 aa)
ENSCPOP00000030838UBIQUITIN_CONJUGAT_2 domain-containing protein. (133 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
UbcUncharacterized protein. (159 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
ENSCPOP00000032088Uncharacterized protein. (191 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (707 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1018 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
TONSLTonsoku like, DNA repair protein. (1395 aa)
MAPK10Mitogen-activated protein kinase 10. (434 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.