42 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDX58	DExD/H-box helicase 58. (915 aa)
	ENSCPOP00000032088	Uncharacterized protein. (191 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (749 aa)
	Ubc	Uncharacterized protein. (159 aa)
	CREBBP	CREB binding protein. (2441 aa)
	NKIRAS2	NFKB inhibitor interacting Ras like 2. (191 aa)
	RNF125	Ring finger protein 125. (228 aa)
	NLRX1	NLR family member X1. (976 aa)
	S100B	Protein S100; Belongs to the S-100 family. (92 aa)
	IRF7	Interferon regulatory factor 7. (441 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (166 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	Herc5	HECT and RLD domain containing E3 ubiquitin protein ligase 5. (1020 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (192 aa)
	Hmgb1	annotation not available (215 aa)
	LOC100725824	HATPase_c domain-containing protein. (695 aa)
	OTUD5	OTU deubiquitinase 5. (571 aa)
	LOC100718750	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (133 aa)
	APP	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
	H0WAS6_CAVPO	Uncharacterized protein. (214 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (549 aa)
	IRF3	Interferon regulatory factor 3. (389 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	NFKBIB	NFKB inhibitor beta. (355 aa)
	MAVS	Mitochondrial antiviral signaling protein. (533 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (609 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	TNFAIP3	TNF alpha induced protein 3. (789 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (739 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (967 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	EP300	E1A binding protein p300. (2425 aa)
	RNF135	Ring finger protein 135. (368 aa)
	RNF216	Ring finger protein 216. (935 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (854 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (723 aa)
	VWC2	Von Willebrand factor C domain containing 2. (315 aa)
	Hsp90aa1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	TAX1BP1	Tax1 binding protein 1. (806 aa)
	AGER	Advanced glycosylation end-product specific receptor. (377 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSCPOP00000000519	ENSCPOP00000020780	Advanced glycosylation end-product specific receptor.	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.711
AGER	ENSCPOP00000032088	ENSCPOP00000000519	ENSCPOP00000032088	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.767
AGER	H0WAS6_CAVPO	ENSCPOP00000000519	ENSCPOP00000020089	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.767
AGER	Hmgb1	ENSCPOP00000000519	ENSCPOP00000023849	Advanced glycosylation end-product specific receptor.	annotation not available	0.767
AGER	NFKB1	ENSCPOP00000000519	ENSCPOP00000007014	Advanced glycosylation end-product specific receptor.	Nuclear factor kappa B subunit 1.	0.570
AGER	NFKB2	ENSCPOP00000000519	ENSCPOP00000004362	Advanced glycosylation end-product specific receptor.	Nuclear factor kappa B subunit 2.	0.547
AGER	RELA	ENSCPOP00000000519	ENSCPOP00000016204	Advanced glycosylation end-product specific receptor.	RELA proto-oncogene, NF-kB subunit.	0.550
AGER	S100B	ENSCPOP00000000519	ENSCPOP00000026644	Advanced glycosylation end-product specific receptor.	Protein S100; Belongs to the S-100 family.	0.993
AGER	Ubc	ENSCPOP00000000519	ENSCPOP00000031925	Advanced glycosylation end-product specific receptor.	Uncharacterized protein.	0.407
APP	AGER	ENSCPOP00000020780	ENSCPOP00000000519	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Advanced glycosylation end-product specific receptor.	0.711
APP	EP300	ENSCPOP00000020780	ENSCPOP00000004894	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	E1A binding protein p300.	0.563
APP	NFKB1	ENSCPOP00000020780	ENSCPOP00000007014	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Nuclear factor kappa B subunit 1.	0.699
APP	NFKB2	ENSCPOP00000020780	ENSCPOP00000004362	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Nuclear factor kappa B subunit 2.	0.622
APP	NFKBIA	ENSCPOP00000020780	ENSCPOP00000004911	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	NFKB inhibitor alpha.	0.401
APP	RELA	ENSCPOP00000020780	ENSCPOP00000016204	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	RELA proto-oncogene, NF-kB subunit.	0.523
APP	S100B	ENSCPOP00000020780	ENSCPOP00000026644	Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Protein S100; Belongs to the S-100 family.	0.645
CHUK	CREBBP	ENSCPOP00000032009	ENSCPOP00000031881	Component of inhibitor of nuclear factor kappa B kinase complex.	CREB binding protein.	0.685
CHUK	EP300	ENSCPOP00000032009	ENSCPOP00000004894	Component of inhibitor of nuclear factor kappa B kinase complex.	E1A binding protein p300.	0.547
CHUK	HSP90AB1	ENSCPOP00000032009	ENSCPOP00000003507	Component of inhibitor of nuclear factor kappa B kinase complex.	Heat shock protein 90 alpha family class B member 1.	0.742
CHUK	Hsp90aa1	ENSCPOP00000032009	ENSCPOP00000001822	Component of inhibitor of nuclear factor kappa B kinase complex.	Heat shock protein 90 alpha family class A member 1.	0.742