STRINGSTRING
TERF2 TERF2 FEN1 FEN1 H0VSI3_CAVPO H0VSI3_CAVPO LOC100735848 LOC100735848 ACD ACD POLD2 POLD2 POLD1 POLD1 TERF1 TERF1 Pold4 Pold4 DNA2 DNA2 RPA3 RPA3 LOC100712757 LOC100712757 TERF2IP TERF2IP POT1 POT1 RPA1 RPA1 BLM BLM WRN WRN Lig1 Lig1 Pold3 Pold3 RPA2 RPA2 PCNA PCNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TERF2Telomeric repeat binding factor 2. (542 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
LOC100735848TINF2_N domain-containing protein. (416 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (421 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
POLD1DNA polymerase. (1134 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa)
Pold4Uncharacterized protein. (107 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
RPA3Replication protein A3. (121 aa)
LOC100712757TINF2_N domain-containing protein. (397 aa)
TERF2IPTERF2 interacting protein. (371 aa)
POT1Protection of telomeres 1. (652 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
BLMBLM RecQ like helicase. (1405 aa)
WRNWRN RecQ like helicase. (1462 aa)
Lig1DNA ligase. (909 aa)
Pold3Uncharacterized protein. (466 aa)
RPA2Replication protein A2. (270 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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