36 items (Cavia porcellus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	Ten1	Uncharacterized protein. (122 aa)
	LOC100712757	TINF2_N domain-containing protein. (397 aa)
	POT1	Protection of telomeres 1. (652 aa)
	TERF2	Telomeric repeat binding factor 2. (542 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
	RPA3	Replication protein A3. (121 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (551 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	BLM	BLM RecQ like helicase. (1405 aa)
	Pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
	POLA1	DNA polymerase. (1467 aa)
	WRN	WRN RecQ like helicase. (1462 aa)
	CTC1	CST telomere replication complex component 1. (1206 aa)
	PRIM2	DNA primase subunit 2. (432 aa)
	Lig1	DNA ligase. (909 aa)
	RFC1	Replication factor C subunit 1. (1153 aa)
	Pold3	Uncharacterized protein. (466 aa)
	RFC3	Replication factor C subunit 3. (220 aa)
	RPA2	Replication protein A2. (270 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa)
	CHTF18	Chromosome transmission fidelity factor 18. (988 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (421 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	RFC2	Replication factor C subunit 2. (352 aa)
	LOC100735848	TINF2_N domain-containing protein. (416 aa)
	H0VSI3_CAVPO	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
	Prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
	RFC5	Replication factor C subunit 5. (340 aa)
	TERF2IP	TERF2 interacting protein. (371 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	POLD1	DNA polymerase. (1134 aa)
	Pold4	Uncharacterized protein. (107 aa)
	DNA2	DNA replication helicase/nuclease 2. (1021 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	BLM	ENSCPOP00000009622	ENSCPOP00000001592	ACD shelterin complex subunit and telomerase recruitment factor.	BLM RecQ like helicase.	0.591
ACD	CTC1	ENSCPOP00000009622	ENSCPOP00000002973	ACD shelterin complex subunit and telomerase recruitment factor.	CST telomere replication complex component 1.	0.796
ACD	LOC100712757	ENSCPOP00000009622	ENSCPOP00000028684	ACD shelterin complex subunit and telomerase recruitment factor.	TINF2_N domain-containing protein.	0.988
ACD	LOC100735848	ENSCPOP00000009622	ENSCPOP00000013336	ACD shelterin complex subunit and telomerase recruitment factor.	TINF2_N domain-containing protein.	0.988
ACD	POT1	ENSCPOP00000009622	ENSCPOP00000030604	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres 1.	0.998
ACD	RPA1	ENSCPOP00000009622	ENSCPOP00000000030	ACD shelterin complex subunit and telomerase recruitment factor.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.610
ACD	RPA2	ENSCPOP00000009622	ENSCPOP00000007868	ACD shelterin complex subunit and telomerase recruitment factor.	Replication protein A2.	0.652
ACD	STN1	ENSCPOP00000009622	ENSCPOP00000025506	ACD shelterin complex subunit and telomerase recruitment factor.	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.	0.872
ACD	TERF1	ENSCPOP00000009622	ENSCPOP00000008651	ACD shelterin complex subunit and telomerase recruitment factor.	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.986
ACD	TERF2	ENSCPOP00000009622	ENSCPOP00000031225	ACD shelterin complex subunit and telomerase recruitment factor.	Telomeric repeat binding factor 2.	0.990
ACD	TERF2IP	ENSCPOP00000009622	ENSCPOP00000016801	ACD shelterin complex subunit and telomerase recruitment factor.	TERF2 interacting protein.	0.987
ACD	Ten1	ENSCPOP00000009622	ENSCPOP00000027995	ACD shelterin complex subunit and telomerase recruitment factor.	Uncharacterized protein.	0.752
ACD	WRN	ENSCPOP00000009622	ENSCPOP00000002674	ACD shelterin complex subunit and telomerase recruitment factor.	WRN RecQ like helicase.	0.981
BLM	ACD	ENSCPOP00000001592	ENSCPOP00000009622	BLM RecQ like helicase.	ACD shelterin complex subunit and telomerase recruitment factor.	0.591
BLM	CHTF18	ENSCPOP00000001592	ENSCPOP00000009070	BLM RecQ like helicase.	Chromosome transmission fidelity factor 18.	0.790
BLM	DNA2	ENSCPOP00000001592	ENSCPOP00000022884	BLM RecQ like helicase.	DNA replication helicase/nuclease 2.	0.953
BLM	FEN1	ENSCPOP00000001592	ENSCPOP00000032223	BLM RecQ like helicase.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.945
BLM	H0VSI3_CAVPO	ENSCPOP00000001592	ENSCPOP00000013590	BLM RecQ like helicase.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.515
BLM	LOC100712757	ENSCPOP00000001592	ENSCPOP00000028684	BLM RecQ like helicase.	TINF2_N domain-containing protein.	0.524
BLM	LOC100735848	ENSCPOP00000001592	ENSCPOP00000013336	BLM RecQ like helicase.	TINF2_N domain-containing protein.	0.524