STRINGSTRING
ZDHHC19 ZDHHC19 APOB APOB AP2A1 AP2A1 CLTC CLTC SOAT2 SOAT2 LOC100728240 LOC100728240 CETP CETP AP2A2 AP2A2 PDIA2 PDIA2 LOC100735467 LOC100735467 PLG PLG CDCP2 CDCP2 P4HB P4HB PLTP PLTP SOAT1 SOAT1 SMPDL3A SMPDL3A APOA5 APOA5 APOF APOF LOC100735934 LOC100735934 ABCG1 ABCG1 APOA2 APOA2 PCSK9 PCSK9 APOA4 APOA4 BMP1 BMP1 Apoc3 Apoc3 AMN AMN SCARB1 SCARB1 PTCHD4 PTCHD4 LCAT LCAT AP2S1 AP2S1 APOC2 APOC2 Mug1 Mug1 H0WAD6_CAVPO H0WAD6_CAVPO LPL LPL LIPC LIPC Alb Alb MYLIP MYLIP PCSK5 PCSK5 Apobr Apobr NPC2 NPC2 LIPA LIPA ZDHHC8 ZDHHC8 UBA52 UBA52 AADACL3 AADACL3 A2M A2M ANGPTL4 ANGPTL4 LMF1 LMF1 APOE APOE CUBN CUBN NPC1 NPC1 ANGPTL3 ANGPTL3 LMF2 LMF2 Ap2b1 Ap2b1 Aadacl4 Aadacl4 ABCA1 ABCA1 H0VEB3_CAVPO H0VEB3_CAVPO PCSK4 PCSK4 LIPG LIPG H0VBH1_CAVPO H0VBH1_CAVPO Rps27a Rps27a APOC1 APOC1 PTCHD3 PTCHD3 H0WDT2_CAVPO H0WDT2_CAVPO LDLR LDLR LSR LSR SAR1B SAR1B VLDLR VLDLR PLEKHD1 PLEKHD1 AP2M1 AP2M1 SAR1A SAR1A HDLBP HDLBP ILDR2 ILDR2 CLTCL1 CLTCL1 NR1H3 NR1H3 GPIHBP1 GPIHBP1 FURIN FURIN PRKACB PRKACB NCEH1 NCEH1 UBB UBB CES3 CES3 CLTA CLTA PTCHD1 PTCHD1 LDLRAP1 LDLRAP1 ENSCPOP00000031632 ENSCPOP00000031632 Ubc Ubc MTTP MTTP APOA1 APOA1 PCSK6 PCSK6 ANGPTL8 ANGPTL8 NR1H2 NR1H2 Prkaca Prkaca ENSCPOP00000033061 ENSCPOP00000033061
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZDHHC19Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (320 aa)
APOBApolipoprotein B. (4479 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
SOAT2O-acyltransferase. (457 aa)
LOC100728240Uncharacterized protein. (1366 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (492 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (937 aa)
PDIA2Protein disulfide isomerase family A member 2. (528 aa)
LOC100735467Uncharacterized protein. (408 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
CDCP2CUB domain containing protein 2. (399 aa)
P4HBProtein disulfide-isomerase. (509 aa)
PLTPPhospholipid transfer protein. (494 aa)
SOAT1O-acyltransferase. (543 aa)
SMPDL3ASphingomyelin phosphodiesterase acid like 3A. (410 aa)
APOA5Apolipoprotein A5. (429 aa)
APOFApolipoprotein F. (321 aa)
LOC100735934Uncharacterized protein. (408 aa)
ABCG1ATP binding cassette subfamily G member 1. (666 aa)
APOA2Apolipoprotein A2. (101 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (686 aa)
APOA4Apolipoprotein A4. (461 aa)
BMP1Metalloendopeptidase. (986 aa)
Apoc3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (91 aa)
AMNAmnion associated transmembrane protein. (453 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
PTCHD4Patched domain containing 4. (895 aa)
LCATLecithin-cholesterol acyltransferase. (441 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (148 aa)
APOC2Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. (100 aa)
Mug1Uncharacterized protein. (1377 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (495 aa)
LIPCLipase C, hepatic type. (497 aa)
AlbPreproalbumin. (608 aa)
MYLIPMyosin regulatory light chain interacting protein. (441 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1856 aa)
ApobrUncharacterized protein. (957 aa)
NPC2NPC intracellular cholesterol transporter 2. (150 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
ZDHHC8Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (751 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
AADACL3Arylacetamide deacetylase like 3. (385 aa)
A2MAlpha-2-macroglobulin. (1475 aa)
ANGPTL4Angiopoietin like 4. (414 aa)
LMF1Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (616 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (298 aa)
CUBNCubilin. (3557 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
ANGPTL3Angiopoietin like 3. (421 aa)
LMF2Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (705 aa)
Ap2b1AP complex subunit beta. (951 aa)
Aadacl4Uncharacterized protein. (390 aa)
ABCA1ATP binding cassette subfamily A member 1. (2200 aa)
H0VEB3_CAVPOUncharacterized protein. (123 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (639 aa)
LIPGLipase G, endothelial type. (498 aa)
H0VBH1_CAVPOUncharacterized protein. (134 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
APOC1Apolipoprotein C1. (95 aa)
PTCHD3Patched domain containing 3. (813 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
LDLRLow density lipoprotein receptor. (807 aa)
LSRLipolysis stimulated lipoprotein receptor. (586 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
VLDLRVery low density lipoprotein receptor. (848 aa)
PLEKHD1Pleckstrin homology and coiled-coil domain containing D1. (506 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
HDLBPHigh density lipoprotein binding protein. (1399 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (570 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (443 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (194 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (796 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
CES3Carboxylesterase 3. (460 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa)
PTCHD1Patched domain containing 1. (888 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (308 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
UbcUncharacterized protein. (159 aa)
MTTPMicrosomal triglyceride transfer protein. (888 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (870 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (463 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
ENSCPOP00000033061AP complex subunit beta. (889 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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