STRINGSTRING
ORC6 ORC6 Clspn Clspn RFC4 RFC4 CDC6 CDC6 MCM2 MCM2 CDK2 CDK2 RPA2 RPA2 RFC3 RFC3 ORC4 ORC4 DBF4 DBF4 MCM10 MCM10 ATR ATR ORC1 ORC1 RPA1 RPA1 RCBTB2 RCBTB2 ATRIP ATRIP RAD17 RAD17 MCM3 MCM3 MCM4 MCM4 RFC2 RFC2 ORC2 ORC2 MCM6 MCM6 RCBTB1 RCBTB1 Mcm8 Mcm8 RPA3 RPA3 CDC25A CDC25A LOC100717396 LOC100717396 ENSCPOP00000025455 ENSCPOP00000025455 CDC45 CDC45 RAD9A RAD9A ORC5 ORC5 RAD1 RAD1 MCM7 MCM7 HUS1 HUS1 MCM5 MCM5 RFC5 RFC5 RAD9B RAD9B Chek1 Chek1 ORC3 ORC3 CDC7 CDC7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC6Origin recognition complex subunit 6. (293 aa)
ClspnUncharacterized protein. (1330 aa)
RFC4Replication factor C subunit 4. (363 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
MCM2DNA helicase; Belongs to the MCM family. (898 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RPA2Replication protein A2. (270 aa)
RFC3Replication factor C subunit 3. (220 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa)
DBF4DBF4 zinc finger. (675 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (834 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (551 aa)
ATRIPATR interacting protein. (792 aa)
RAD17RAD17 checkpoint clamp loader component. (696 aa)
MCM3DNA helicase; Belongs to the MCM family. (810 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
RFC2Replication factor C subunit 2. (352 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (833 aa)
RPA3Replication protein A3. (121 aa)
CDC25ACell division cycle 25A. (519 aa)
LOC100717396Uncharacterized protein. (1249 aa)
ENSCPOP00000025455Protein kinase domain-containing protein. (360 aa)
CDC45Cell division cycle 45. (566 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa)
ORC5Origin recognition complex subunit 5. (414 aa)
RAD1RAD1 checkpoint DNA exonuclease. (282 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
MCM5DNA helicase; Belongs to the MCM family. (731 aa)
RFC5Replication factor C subunit 5. (340 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (401 aa)
Chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
ORC3Origin recognition complex subunit 3. (710 aa)
CDC7Cell division cycle 7. (560 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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