STRINGSTRING
SH3GL2 SH3GL2 EGFR EGFR UBA52 UBA52 PXN PXN EGF EGF AAMP AAMP LRIG1 LRIG1 SOS1 SOS1 STAM2 STAM2 FNDC3A FNDC3A SH3GL3 SH3GL3 RNF222 RNF222 Rps27a Rps27a SH3KBP1 SH3KBP1 PIK3CA PIK3CA LRIG2 LRIG2 PIK3R1 PIK3R1 STAM STAM TGFA TGFA PTPN3 PTPN3 HBEGF HBEGF ARHGEF7 ARHGEF7 NRAS NRAS KRAS KRAS PTPRK PTPRK LRIG3 LRIG3 FNDC3B FNDC3B LPXN LPXN GAB1 GAB1 PTPN11 PTPN11 EPGN EPGN PTPRT PTPRT HRAS HRAS SPRY1 SPRY1 Ubc Ubc CSDE1 CSDE1 GRB2 GRB2 ENSCPOP00000031632 ENSCPOP00000031632 CDC42 CDC42 SPRY2 SPRY2 EPS15 EPS15 PTPRM PTPRM EREG EREG UBB UBB CBL CBL TGFB1I1 TGFB1I1 PAG1 PAG1 AREG AREG EPS15L1 EPS15L1 CSK CSK H0WDT2_CAVPO H0WDT2_CAVPO BTC BTC H0WAD6_CAVPO H0WAD6_CAVPO SH3GL1 SH3GL1 HGS HGS SHC1 SHC1 PLCG1 PLCG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (376 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (588 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
AAMPAngio associated migratory cell protein. (436 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1089 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
STAM2Signal transducing adaptor molecule 2. (519 aa)
FNDC3AFibronectin type III domain containing 3A. (1172 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
RNF222Ring finger protein 222. (215 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (716 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1044 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1063 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
STAMSignal transducing adaptor molecule. (537 aa)
TGFATransforming growth factor alpha. (159 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (912 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (753 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (189 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1455 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1120 aa)
FNDC3BFibronectin type III domain containing 3B. (1101 aa)
LPXNLeupaxin. (381 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
EPGNEpithelial mitogen. (133 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1395 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
UbcUncharacterized protein. (159 aa)
CSDE1Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
CDC42Cell division cycle 42. (191 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (935 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1445 aa)
EREGEpiregulin. (164 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
CBLCbl proto-oncogene. (894 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (435 aa)
AREGAmphiregulin. (241 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (905 aa)
CSKTyrosine-protein kinase. (450 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
BTCBetacellulin. (183 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (359 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (778 aa)
SHC1SHC adaptor protein 1. (583 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1235 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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