STRINGSTRING
PTPRM PTPRM SPRY1 SPRY1 Ubc Ubc GRB2 GRB2 ENSCPOP00000031632 ENSCPOP00000031632 CDC42 CDC42 SPRY2 SPRY2 SH3KBP1 SH3KBP1 STAM STAM TGFA TGFA PTPN3 PTPN3 HBEGF HBEGF ARHGEF7 ARHGEF7 PTPRK PTPRK EPGN EPGN PTPRT PTPRT SH3GL2 SH3GL2 HGS HGS SH3GL1 SH3GL1 H0WAD6_CAVPO H0WAD6_CAVPO BTC BTC H0WDT2_CAVPO H0WDT2_CAVPO EPS15L1 EPS15L1 AREG AREG EPS15 EPS15 EGFR EGFR UBA52 UBA52 EGF EGF STAM2 STAM2 SH3GL3 SH3GL3 Rps27a Rps27a CBL CBL UBB UBB EREG EREG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPRMProtein tyrosine phosphatase receptor type M. (1445 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
UbcUncharacterized protein. (159 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSCPOP00000031632Ubiquitin-like domain-containing protein. (141 aa)
CDC42Cell division cycle 42. (191 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (716 aa)
STAMSignal transducing adaptor molecule. (537 aa)
TGFATransforming growth factor alpha. (159 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (912 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (753 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1455 aa)
EPGNEpithelial mitogen. (133 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1395 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (376 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (778 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (359 aa)
H0WAD6_CAVPOUbiquitin-like domain-containing protein. (111 aa)
BTCBetacellulin. (183 aa)
H0WDT2_CAVPOUbiquitin-like domain-containing protein. (127 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (905 aa)
AREGAmphiregulin. (241 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (935 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1194 aa)
STAM2Signal transducing adaptor molecule 2. (519 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
Rps27aUbiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] (156 aa)
CBLCbl proto-oncogene. (894 aa)
UBBPolyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] (229 aa)
EREGEpiregulin. (164 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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